Protein Alignment ESRRG and nhr-108

DIOPT Version :10

• Sequence 1: XP_011507567.1
• Gene: ESRRG / 2104
• HGNCID: 3474
• Length: 477
• Species: Homo sapiens
• Sequence 2: NP_506987.1
• Gene: nhr-108 / 180065
• WormBaseID: WBGene00003698
• Length: 338
• Species: Caenorhabditis elegans
• Alignment Length: 370
• Identity: 92/370 - (24%)
• Similarity: 154/370 - (41%)
• Gaps: 87/370 - (23%)

Human   140 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVG 204
            |:|||:|:....:|..||.||..||:|.|.............|::.|..||:||:|||.||||:|
 Worm    10 CMVCGEISYSIRFGAVSCRACAEFFRRKIVSKARIPKRCNGACDLGKYHRKTCQSCRFQKCLKIG 74

Human   205 MLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPLLWSDPAD------NKIVSHLLVA 263
            |      |::|...|....||  :||:..:...|.:...|   ..:..|      |||..:....
 Worm    75 M------LEKVVASRTPVNRR--SENNQTILSGLEKAYDK---LENSRDNVFDRKNKIPKYCNHQ 128

Human   264 EPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGF--STLSLADQMSLLQSAW-- 324
            |.:.::        :.|||.::|                 |...|  |..||.:..:.:.|..
 Worm   129 ELDDMF--------EIDIKLIST-----------------HFIQFFESKSSLENNQNKVLSTHFI 168

Human   325 MEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLD-----------LNNAILQLV--KKYK 376
            :...:|.|.:|:......::..:|.|   |.|||..:..           .:..|||..  ...|
 Worm   169 IRFSLLEVAFRAFGKPTYILPNNDII---DVSKLDKVYQHLETGEDERGKNSQVILQRFWQMNEK 230

Human   377 SMK-------LEKEEFVTLKAI-----ALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMED 429
            :||       |::.||:.|.|:     .:.|.....:|:   .|:::..:.:.|.:||...:.|:
 Worm   231 TMKTEVFPVNLDQSEFLFLCALIYWDFGIENQSEKCLEE---CQRMRTQVLKELTEYEKSNYPEN 292

Human   430 PRRAGKMLMTLPLLRQTSTKAVQH------FYNIKLEGK-VPMHK 467
            ..|..:::..|..|::| ...:||      .||:|  || .|:::
 Worm   293 ELRVAQVIGILQALQKT-LDVIQHSGYISNVYNLK--GKQCPLYE 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ESRRG	XP_011507567.1	NR_DBD_ERR	134..230	CDD:143544	34/89 (38%)
		NR_LBD_ERR	256..475	CDD:132744	51/248 (21%)
nhr-108	NP_506987.1	ZnF_C4	9..75	CDD:197701	27/64 (42%)
		HOLI	134..309	CDD:214658	40/205 (20%)