Protein Alignment ESRRB and nhr-146

DIOPT Version :10

• Sequence 1: XP_011534849.1
• Gene: ESRRB / 2103
• HGNCID: 3473
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_001122810.1
• Gene: nhr-146 / 6418682
• WormBaseID: WBGene00045255
• Length: 365
• Species: Caenorhabditis elegans
• Alignment Length: 350
• Identity: 95/350 - (27%)
• Similarity: 156/350 - (44%)
• Gaps: 61/350 - (17%)

Human   124 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSC--PATNECEITKRRRKSCQACRFMKCLK 186
            |.||..:::|:|:||..|.||.|||:||:.....:.|  ...|.|||.......|::|||.|||.
 Worm     5 CPVCQALSNGFHFGVEVCSACSAFFRRTVFKKRNFRCWGEPVNCCEIVSTGSAFCKSCRFAKCLA 69

Human   187 VGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKK--------PL--TKIVSYLLVAE 241
            |||.||     .|:.||:.|.:|         .:.:.|...|        |:  |.:.:|.|:..
 Worm    70 VGMKKE-----TVQQGREGYGKR---------EMALVPVISKFKANRQGLPILETIVETYSLLLN 120

Human   242 PDKLYAMPPPG--MPEGDIKAL----TTLCDLADRELVVIIGWAKH-IPGFSSLSLGDQMSLL-Q 298
            ........|.|  .|:.|.|.:    |..|.|  :|..::..|..| .|.|::..: ||..|| :
 Worm   121 VRICVHEGPNGSNSPKRDPKPVNYKETIACFL--KEFYLVGDWLSHCFPEFAAFPV-DQKDLLHR 182

Human   299 SAWMEILIL--GIV--------YRSLPYDDKL--VYAEDYIMDEEHSR---LAGLLELYRAILQL 348
            :.:::.::|  |..        .|.||..|.:  |..|.|..|.:..:   ....:.|:.:..|.
 Worm   183 NFYLQFVVLEGGFFSCNHKRSDIRYLPSGDYIDCVNPETYYYDPDGKQPMTPGEAVTLFASSFQS 247

Human   349 VRR---YKKLK--VEKEEFVTLKALALANSDSMYI-EDLEAV-QKLQDLLHEALQDYELSQRHEE 406
            .||   :..|:  .::.||:.|..|||.::|...| |:..|| :|::..:...:..|.:|.:..|
 Worm   248 YRRNVTHPMLRENADRFEFLALTGLALFDADLENISEETAAVCRKVRQKIQRNMLKYYISTKSPE 312

Human   407 --PWRTGKLLLTLPLLRQTAAKAVQ 429
              ..|.|.|:..:|.|.:...:.::
 Worm   313 DASVRLGNLISIIPSLHRATRRFLE 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ESRRB	XP_011534849.1	NR_DBD_ERR	119..214	CDD:143544	37/91 (41%)
		NR_LBD_ERR	233..452	CDD:132744	54/228 (24%)
nhr-146	NP_001122810.1	ZnF_C4	4..75	CDD:197701	30/69 (43%)
		Hormone_recep	132..331	CDD:459675	50/201 (25%)