Protein Alignment ESR1 and eg

DIOPT Version :10

• Sequence 1: NP_001278159.1
• Gene: ESR1 / 2099
• HGNCID: 3467
• Length: 597
• Species: Homo sapiens
• Sequence 2: NP_524206.1
• Gene: eg / 40428
• FlyBaseID: FBgn0000560
• Length: 373
• Species: Drosophila melanogaster
• Alignment Length: 157
• Identity: 34/157 - (21%)
• Similarity: 50/157 - (31%)
• Gaps: 45/157 - (28%)

Human   200 PGGLAESTGLLAVNDEVLEVNGIEVAGKTLDQVTDMMIANSHNLIVTVKPANQRNNVVRSSRTSG 264
            |.|  ..|||...||....:.|.....|.|          ..|:..|.|| .|....||..|  |
  Fly   104 PSG--APTGLFGPNDWACPMCGNVNWAKRL----------KCNICNTNKP-GQNEGGVRGGR--G 153

Human   265 SSVHSTDSTTSHHSLPGAHVLQNSEDVE------SDEEADIVIE-GALEPQHIPKTQAV---PPG 319
            ......|.             |..|:.:      .:::.::..| |.|:.::..||...   |..
  Fly   154 GGYKELDE-------------QELEETKRRRREAEEDDGEMYDEFGNLKKKYRVKTNQADTRPAV 205

Human   320 SLSRANGTSLAHGLHRRDMSLHSSGRE 346
            :..||       |....::.:...|||
  Fly   206 AAGRA-------GWEVEELGIDKDGRE 225

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ESR1	NP_001278159.1	Modulating (transactivation AF-1), mediates interaction with MACROD1. /evidence=ECO:0000269|PubMed:17914104	1..184
		Interaction with DDX5, self-association. /evidence=ECO:0000269|PubMed:11682626	35..174
		Required for interaction with NCOA1. /evidence=ECO:0000269|PubMed:11682626	35..47
		Oest_recep	42..181	CDD:460469
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	147..174
		NR_DBD_ER	180..263	CDD:143545	18/62 (29%)
		Hinge	253..312		10/65 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..284		3/22 (14%)
		Interaction with AKAP13. /evidence=ECO:0000269|PubMed:9627117	264..597		16/93 (17%)
		Self-association	266..597		15/91 (16%)
		NR_LBD_ER	312..549	CDD:132747	9/38 (24%)
		Transactivation AF-2	313..597		8/37 (22%)
		ESR1_C	554..597	CDD:432757
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	555..575
eg	NP_524206.1	NR_DBD_like	3..87	CDD:413390