DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ESR1 and kni

DIOPT Version :10

Sequence 1:NP_001278159.1 Gene:ESR1 / 2099 HGNCID:3467 Length:597 Species:Homo sapiens
Sequence 2:NP_001287130.1 Gene:kni / 40287 FlyBaseID:FBgn0001320 Length:434 Species:Drosophila melanogaster


Alignment Length:218 Identity:68/218 - (31%)
Similarity:91/218 - (41%) Gaps:57/218 - (26%)


- Green bases have known domain annotations that are detailed below.


Human   185 CAVCNDYASGYHYGVWSCEGCKAFFKRSIQGNRHNDYMCPATNQCTIDKNRRKSCQACRLRKCYE 249
            |.||.:.|:|:|:|.::|||||:||.|| ..|......|....:|.|||..|.:|:||||||||.
  Fly    10 CKVCGEPAAGFHFGAFTCEGCKSFFGRS-YNNISTISECKNEGKCIIDKKNRTTCKACRLRKCYN 73

Human   250 VGMMKGGIRKDRRGG-----RMLKHKRQRDDGEGRG-------EVGSA---------------GD 287
            |||.|||.|..||..     .:|:...|.....|:.       .||.|               ||
  Fly    74 VGMSKGGSRYGRRSNWFKIHCLLQEHEQAAAAAGKAPPLAGGVSVGGAPSASSPVGSPHTPGFGD 138

Human   288 MRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEP--PIL-YSEY--DPTRPFSEASMMGL 347
            |.|                  .|.....|.....:...|  |:| |..|  ||:......||||.
  Fly   139 MAA------------------HLHHHHQQQQQQQVPRHPHMPLLGYPSYLSDPSAALPFFSMMGG 185

Human   348 LTNLADREL-VHMINWAKRVPGF 369
            :.:.:..:| .|::     .||:
  Fly   186 VPHQSPFQLPPHLL-----FPGY 203

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ESR1NP_001278159.1 Modulating (transactivation AF-1), mediates interaction with MACROD1. /evidence=ECO:0000269|PubMed:17914104 1..184
Interaction with DDX5, self-association. /evidence=ECO:0000269|PubMed:11682626 35..174
Required for interaction with NCOA1. /evidence=ECO:0000269|PubMed:11682626 35..47
Oest_recep 42..181 CDD:460469
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 147..174
NR_DBD_ER 180..263 CDD:143545 40/77 (52%)
Hinge 253..312 17/85 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..284 6/34 (18%)
Interaction with AKAP13. /evidence=ECO:0000269|PubMed:9627117 264..597 27/139 (19%)
Self-association 266..597 27/132 (20%)
NR_LBD_ER 312..549 CDD:132747 16/64 (25%)
Transactivation AF-2 313..597 16/63 (25%)
ESR1_C 554..597 CDD:432757
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 555..575
kniNP_001287130.1 NR_DBD_like 8..92 CDD:413390 41/82 (50%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.