| Sequence 1: | NP_001278159.1 | Gene: | ESR1 / 2099 | HGNCID: | 3467 | Length: | 597 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_788552.1 | Gene: | knrl / 40285 | FlyBaseID: | FBgn0001323 | Length: | 647 | Species: | Drosophila melanogaster |
| Alignment Length: | 125 | Identity: | 45/125 - (36%) |
|---|---|---|---|
| Similarity: | 59/125 - (47%) | Gaps: | 19/125 - (15%) |
- Green bases have known domain annotations that are detailed below.
|
Human 185 CAVCNDYASGYHYGVWSCEGCKAFFKRSIQGNRHNDYMCPATNQCTIDKNRRKSCQACRLRKCYE 249
Human 250 VGMMKGGIRKDRRG-----------------GRMLKHKRQRDDGEGRGEVGSAGDMRAAN 292 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| ESR1 | NP_001278159.1 | Modulating (transactivation AF-1), mediates interaction with MACROD1. /evidence=ECO:0000269|PubMed:17914104 | 1..184 | ||
| Interaction with DDX5, self-association. /evidence=ECO:0000269|PubMed:11682626 | 35..174 | ||||
| Required for interaction with NCOA1. /evidence=ECO:0000269|PubMed:11682626 | 35..47 | ||||
| Oest_recep | 42..181 | CDD:460469 | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 147..174 | ||||
| NR_DBD_ER | 180..263 | CDD:143545 | 36/77 (47%) | ||
| Hinge | 253..312 | 13/57 (23%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 261..284 | 6/39 (15%) | |||
| Interaction with AKAP13. /evidence=ECO:0000269|PubMed:9627117 | 264..597 | 8/29 (28%) | |||
| Self-association | 266..597 | 8/27 (30%) | |||
| NR_LBD_ER | 312..549 | CDD:132747 | |||
| Transactivation AF-2 | 313..597 | ||||
| ESR1_C | 554..597 | CDD:432757 | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 555..575 | ||||
| knrl | NP_788552.1 | NR_DBD_like | 12..96 | CDD:413390 | 37/82 (45%) |
| Blue background indicates that the domain is not in the aligned region. | |||||