Protein Alignment Synj2 and Synj

DIOPT Version :9

• Sequence 1: NP_001106824.1
• Gene: Synj2 / 20975
• MGIID: 1201671
• Length: 1479
• Species: Mus musculus
• Sequence 2: NP_001246454.1
• Gene: Synj / 37517
• FlyBaseID: FBgn0034691
• Length: 1218
• Species: Drosophila melanogaster
• Alignment Length: 1381
• Identity: 555/1381 - (40%)
• Similarity: 759/1381 - (54%)
• Gaps: 221/1381 - (16%)

Mouse     1 MALSKGLRLLARLDPTGPSSVLLEARGRGDCLLFEAGAVATLAPEEKEVIKGLYSKLTDAYGCLG 65
            ||:||.:|:|.:.....|.|||||.|.:.|.:|||:.|||.|..:|.:||:..|:|:.|||||||
  Fly     1 MAMSKVIRVLEKSIAPSPHSVLLEHRNKSDSILFESHAVALLTQQETDVIRKQYTKVCDAYGCLG 65

Mouse    66 ELRLQSGGVPLSFLVLVTGCMSVGRIPDAEIYKITATELYPLQEEAKEEDRLPTLKKILSSGVFY 130
            .|:|.:|...:.||||||||:|:|:|.|.||::||.|....||..|..||::..::|:|:||.||
  Fly    66 ALQLNAGESTVLFLVLVTGCVSMGKIGDIEIFRITQTTFVSLQNAAPNEDKISEVRKLLNSGTFY 130

Mouse   131 FAWPNDGAC--------FDLTIRAQKQGDDGSEWGTSFFWNQLLHVPLRQHQVNCHNWLLKVICG 187
            ||..|..|.        ||:|:.||:: ....|....||||:::|:.|.:..::|.:|||:.:||
  Fly   131 FAHTNASASASGASSYRFDITLCAQRR-QQTQETDNRFFWNRMMHIHLMRFGIDCQSWLLQAMCG 194

Mouse   188 VVTIRTVYASHKQAKACLISRISCERAGARFLTRGVNDDGHVSNFVETEQTIYMDDGVSSFVQIR 252
            .|.:||||...|||:|.:|||:||||||.||..||.||:|:|:|||||||.||:|..|:|:||.|
  Fly   195 SVEVRTVYIGAKQARAAIISRLSCERAGTRFNVRGTNDEGYVANFVETEQVIYVDGDVTSYVQTR 259

Mouse   253 GSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFERHMVLLKEQYGKQVVVNLL-----GSRGGEEV 312
            |||||||||||:|||||.::|.||.|.:|.||:|||.:::::||.|.|||||     ||:.||.:
  Fly   260 GSVPLFWEQPGVQVGSHKVKLSRGFETSAAAFDRHMSMMRQRYGYQTVVNLLGSSLVGSKEGEAM 324

Mouse   313 LNRAFKKLLWASCHAGDTPMINFDFHQFAKGRKLEKLENLLRPQLQLHWEDFGVFAKGENVSPRF 377
            |:..|::....|.|. |.|.:.||:||..:|.....|.. |:.::.....::|||........|.
  Fly   325 LSNEFQRHHGMSAHK-DVPHVVFDYHQECRGGNFSALAK-LKERIVACGANYGVFHASNGQVLRE 387

Mouse   378 QKGTLRMNCLDCLDRTNTVQCFIALEVLHLQLESLGLNSK-PIIDRFVESFKAMWSLNGHSLSKV 441
            |.|.:|.||||||||||.||.::.|:.|.:|||:|.:..| ..|.||.|.|:.||..||:.:||:
  Fly   388 QFGVVRTNCLDCLDRTNCVQTYLGLDTLGIQLEALKMGGKQQNISRFEEIFRQMWINNGNEVSKI 452

Mouse   442 FTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYNEESTDKGRMLLDNTA 506
            :.|:.|::|.:   ||.|||||.:||||:|..|..|||||.:||||...:.|..|:.|:||.:..
  Fly   453 YAGTGAIQGGS---KLMDGARSAARTIQNNLLDNSKQEAIDVLLVGSTLSSELADRARILLPSNM 514

Mouse   507 LLATPRILKAMTERQSEFTNFKRIQIAVGTWNVNGGKQFRSNLLGTAELTDWLLDAPQLS---GA 568
            |.|...:|:.:.:|.:|:...:..::||||:||||||.||| ::....|.|||||...|:   ..
  Fly   515 LHAPTTVLRELCKRYTEYVRPRMARVAVGTYNVNGGKHFRS-IVFKDSLADWLLDCHALARSKAL 578

Mouse   569 VD----SQDDGSPADVFAIGFEEMVELSAGNIVNASTTNRKMWGEQLQKAISRSHRYILLTSAQL 629
            ||    |::...|.|::||||||:|:|:|.||:.|||.|.|:|.|:|||.|||.:.|:|||..||
  Fly   579 VDVNNPSENVDHPVDIYAIGFEEIVDLNASNIMAASTDNAKLWAEELQKTISRDNDYVLLTYQQL 643

Mouse   630 VGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQLHSTSFCFVCSHLTAGQSQVK 694
            |||||||::||.|.|.|||||||.||||:||..|||||..|||.||.||.||||:|..||||||.
  Fly   644 VGVCLYIYIRPEHAPHIRDVAIDCVKTGLGGATGNKGACAIRFVLHGTSMCFVCAHFAAGQSQVA 708

Mouse   695 ERNEDYREITHKLSFPSGRNIFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLMEFDQLQLQ 759
            |||.||.|||.||:||.||.:.|||:||||||||||||:..:|:...|:..|...::|||||:.:
  Fly   709 ERNADYAEITRKLAFPMGRTLKSHDWVFWCGDFNYRIDMEKDELKECVRNGDLSTVLEFDQLRKE 773

Mouse   760 KSSGKIFKDFHEGAVNFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPYDKTAGELNLLD 824
            :.:|.:|.:|.||.:.|.||||||:.|..||||:|.|.|||||||||.|:|          .|.:
  Fly   774 QEAGNVFGEFLEGEITFDPTYKYDLFSDDYDTSEKQRAPAWTDRVLWRRRK----------ALAE 828

Mouse   825 SDLDGDPQIRHTWSPGTLKYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSVQGPLD 889
            .|....     .|:||.|.:|||:||:.||||||:||::.|:.|:|...|..||::|....||.|
  Fly   829 GDFAAS-----AWNPGKLIHYGRSELKQSDHRPVIAIIDAEIMEIDQQRRRAVFEQVIRDLGPPD 888

Mouse   890 ATVVVNL---------QSPTLEEKNEFPEDLRTELMQTLGNYGTIILVRINQGQMLVTFADSHSA 945
            :|:||::         ..||:     :.|::.:.|:..|...|.:.|||..:..|.|||.|..||
  Fly   889 STIVVHVLESSATGDEDGPTI-----YDENVMSALITELSKMGEVTLVRYVEDTMWVTFRDGESA 948

Mouse   946 LSVLDVDGMKVKGRAVKIRPKTKDWLEGLREELLRKRDSMAPVSPTANSCLLEENFDFSSLDYES 1010
            |:......::|.|..:.:..|:|||
  Fly   949 LNASSKKSIQVCGLDLILELKSKDW---------------------------------------- 973

Mouse  1011 EGDVLEEDEDYLVDGFGQPVVSDSELGGDNSSDTMSSLTPASKSPALAKKKQHPTYKDDAHLVTL 1075
                     .:|||       |:.||...|:            .|..|...:|...     |..:
  Fly   974 ---------QHLVD-------SEIELCTTNT------------IPLCANPVEHAQL-----LQAI 1005

Mouse  1076 KQELEVAGNFRHRSPSRSLSVPNRPR--PPHPPQRPPPPTGLMVKKSASDASISSGTH----GQY 1134
            ..||                 |.||:  |..||.|||.|   |..|       :|..|    |..
  Fly  1006 TPEL-----------------PQRPKQPPTRPPARPPMP---MSPK-------NSPRHLPHVGVI 1043

Mouse  1135 SIL------------QTAKLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEASGG 1187
            ||:            |:..|:| :|.||..|      |.....:.||.:.::::... |:.||..
  Fly  1044 SIVPKPAKPPMPPQPQSQPLIP-SPLQPQVA------PPRPPAMDTTPSSKSQSPTE-LVSASSS 1100

Mouse  1188 VPESAPGAIPLRNQGSSKPEATL---GPPALPRRPAPRVPTMKKPTLRRTGKPMLPEENFEPQPV 1249
            ...|          |.:.|.|..   |||..||:...:..|......|:.|.|..|    .|...
  Fly  1101 TSSS----------GKTSPTAPAVLSGPPTPPRQMQSKQATPVSTPTRQVGSPKDP----IPSDT 1151

Mouse  1250 HFTMAS---QEMNLETPPPITATPIPPVPKPRTLQPGKGVEGRPSSGKPEPDEAPSVTGTVESPP 1311
            .:..||   :|:..:.|.|....|..|.|          |.|.| .|.|.|  .|:..|    ||
  Fly  1152 AYETASNIYEEIQEDVPAPRHPPPAGPPP----------VIGAP-MGPPPP--LPNRRG----PP 1199

Mouse  1312 PEAQEAPSLAPKVPPR 1327
            |....:.: ||.:|.|
  Fly  1200 PIPNRSGN-APPLPTR 1214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Synj2	NP_001106824.1	Syja_N	61..342	CDD:280532	147/293 (50%)
		EEP	530..861	CDD:294334	186/337 (55%)
		DUF1866	872..1008	CDD:286093	33/144 (23%)
		CEND1	1290..>1405	CDD:292305	13/38 (34%)
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532	147/293 (50%)
		INPP5c_Synj	538..863	CDD:197323	188/340 (55%)
		DUF1866	862..1008	CDD:286093	47/223 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836221
Domainoid	1	1.000	54	1.000	Domainoid score	I11179
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	1	1.000	-	-		FOG0002172
OrthoInspector	1	1.000	-	-		otm43870
orthoMCL	1	0.900	-	-		OOG6_101787
Panther	1	1.100	-	-	O	PTHR11200
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1445
SonicParanoid	1	1.000	-	-		X1883
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.740