DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Suv39h1 and Su(var)3-9

DIOPT Version :9

Sequence 1:	XP_011245754.1	Gene:	Suv39h1 / 20937	MGIID:	1099440	Length:	432	Species:	Mus musculus
Sequence 2:	NP_524357.2	Gene:	Su(var)3-9 / 41483	FlyBaseID:	FBgn0263755	Length:	635	Species:	Drosophila melanogaster

Alignment Length:	447	Identity:	155/447 - (34%)
Similarity:	223/447 - (49%)	Gaps:	87/447 - (19%)

- Green bases have known domain annotations that are detailed below.

Mouse     2 GEPATLGCSVCCKSSWNQLQDLCRLAKL-----SC-----PALGVSKKNL---------YDFEVE 47
            |..:..||.   :...:::..|...|||     ||     |....||.|:         .::.||
  Fly   161 GYGSVFGCE---EHDVDKIPSLNGFAKLKRRRSSCVGAPTPNSKRSKNNMGVIAKRPPKGEYVVE 222

Mouse    48 YLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNLKCIRVLKQF---HK------------DLERE 97
            .:...:..:.|..:.|||.||.|||||||...|:.....:::|   |:            :||::
  Fly   223 RIECVEMDQYQPVFFVKWLGYHDSENTWESLANVADCAEMEKFVERHQQLYEIYIAKITTELEKQ 287

Mouse    98 ----------------------------LVRRHRRSKPPRHLDPN------LANYLVQKA----- 123
                                        |:.::|.:......:|.      |.:..:::|
  Fly   288 LEALPLMENITVAEVDAYEPLNLQIDLILLAQYRAAGSRSQREPQKIGERALKSMQIKRAQFVRR 352

Mouse   124 KQRRALQRWEQELNAKRSHLGRITVENEVDLDGPPRSFVYINEYRVGEGITLNQVA-VGCEC--- 184
            ||...|..:|:.:|........|.|||.:|||....:|:||::..:|:.:...:.. |||:|
  Fly   353 KQLADLALFEKRMNHVEKPSPPIRVENNIDLDTIDSNFMYIHDNIIGKDVPKPEAGIVGCKCTED 417

Mouse   185 -QDCLLAPTGGCCPGASLHKFAY-NDQGQVRLKAGQPIYECNSRCCCGYDCPNRVVQKGIRYDLC 247
             ::|..:..  ||...:...||| ....::||:.|..||||||||.|...|.||:||.|.:..|.
  Fly   418 TEECTASTK--CCARFAGELFAYERSTRRLRLRPGSAIYECNSRCSCDSSCSNRLVQHGRQVPLV 480

Mouse   248 IFRTNDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDY---VEDVY 309
            :|:|.:|.|||||....:||..||.||:||||||:||..||:.||..|.||||||||   .:..|
  Fly   481 LFKTANGSGWGVRAATALRKGEFVCEYIGEIITSDEANERGKAYDDNGRTYLFDLDYNTAQDSEY 545

Mouse   310 TVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIWAGEELTFDY 366
            |:|||.|||||||:||||||||.|:..:|::|:..||.:.||..|.|.|||||:|||
  Fly   546 TIDAANYGNISHFINHSCDPNLAVFPCWIEHLNVALPHLVFFTLRPIKAGEELSFDY 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Suv39h1	XP_011245754.1	CD_SUV39H1_like	44..92	CDD:349289	17/50 (34%)
Suv39h1	XP_011245754.1	SET	159..372	CDD:394802	105/217 (48%)
Su(var)3-9	NP_524357.2	P-loop_NTPase	41..>80	CDD:304359
		CHROMO	217..268	CDD:237991	17/50 (34%)
		PreSET	362..455	CDD:128744	27/94 (29%)
		SET	477..609	CDD:214614	73/126 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833523
Domainoid	1	1.000	146	1.000	Domainoid score	I4526
eggNOG	1	0.900	-	-		E2759_KOG1082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3184
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D589939at33208
OrthoFinder	1	1.000	-	-		FOG0001837
OrthoInspector	1	1.000	-	-		otm43794
orthoMCL	1	0.900	-	-		OOG6_100876
Panther	1	1.100	-	-	LDO	PTHR46223
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R211
SonicParanoid	1	1.000	-	-		X219
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.790