Protein Alignment Abcc9 and MRP

DIOPT Version :9

• Sequence 1: NP_035641.1
• Gene: Abcc9 / 20928
• MGIID: 1352630
• Length: 1546
• Species: Mus musculus
• Sequence 2: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Alignment Length: 1677
• Identity: 533/1677 - (31%)
• Similarity: 832/1677 - (49%)
• Gaps: 282/1677 - (16%)

Mouse     5 FCGNNI-SSYNIYYGVLQN-----PCFVD-ALNLVPHVFL-LFITFPILFIGWGSQSSKVQIHHN 61
            |||:.. ::...:|   .|     |||.. ||...|..|. .|:.|...::       |..:..|
  Fly    12 FCGSTFWNATETWY---TNDPDFTPCFEQTALVWTPCAFYWAFVIFDFYYL-------KASLDRN 66

Mouse    62 TWLHFPGHNL---RWILTFALLFVHVCEIAEGIV---SDSHRASRHLHLFMPAVMGFVATTTSIV 120
                .|.:.|   :.::...||.:...::...:|   .||......|.::.| ::.|.......:
  Fly    67 ----IPWNKLNVSKALVNLGLLVITALDLIMALVKKGGDSELPLYDLDVWGP-IIKFATFLLLFI 126

Mouse   121 YY-----HNIETSNFPKLLLALFLYWVMAFITKTIKLVK-------------------------Y 155
            :.     :.::|:.      ..|::|   |:...:.:.:                         .
  Fly   127 FIPLNRKYGVQTTG------CQFIFW---FLLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFS 182

Mouse   156 WQLGWGVS-DLRFCITGVMVILN----GLLMAVEINVIRVRRYVFFMNPQKVK---PPEDLQDLG 212
            |:....|| .:.|..|.:|:|||    |:                   |::.|   ...::.:|.
  Fly   183 WEEYQFVSFFIFFTFTSIMLILNCFADGM-------------------PRQTKYQRGENEIPELS 228

Mouse   213 VRFLQPFVNLLSKATYWWMNTLIISAHRKPIDLKAIGKL----------PI-----AMRAVTNYV 262
            ..|       ||:.||.|.:.:.:..:|.|::.|.:..|          ||     ......||
  Fly   229 ASF-------LSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNY- 285

Mouse   263 CLKEAYEEQKKKAADHPNRT---------------PSIWLAMYRAFGRPILLSSTFRYLADLLGF 312
              |.....:.|....:.|.|               .||...:|::||...|..:..:...|.|.|
  Fly   286 --KNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTF 348

Mouse   313 AGPLCISGIVQRVNEKTNTTREMFPETLSSKEFLENAHVLAVLLFLALILQRTFLQASYYVTI-E 376
            |.|..:|.|:..|.     .::..||.        ...:.|||||: |...:||:...|:..: .
  Fly   349 AQPQVLSLIISFVE-----AQDAEPEW--------KGILYAVLLFV-LAAAQTFILGQYFHRMFI 399

Mouse   377 TGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIM 441
            .|:.:|.||:..||.|.||:  ||.:..|.|:|:|.||:|::..:.|........:|:.|:||.:
  Fly   400 VGLRIRTALINAIYRKALRI--SNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGL 462

Mouse   442 GVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLY 506
            .:..|:..||.|.|.|.||:::|.|:...||:::...|...:.|..||:|..||:|.|||:||||
  Fly   463 ALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLY 527

Mouse   507 AWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYAS-GNNLKPAEAF 570
            |||..|.|.|.:.|.||:::|::.|...:.:.|:.:..|....|.||.|:...| .|.|...:..
  Fly   528 AWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVL 592

Mouse   571 ASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGEDSWRAGEGTLPFESCKKHTGV 635
            .|::||.::..||.:|..:.....:..:||.::|:||.|:|:..:|       :..:|.|.|
  Fly   593 VSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNS-------VLHDSSKPH--- 647

Mouse   636 QSKPINRKQPGRYHLDSYEQARRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMI 700
                                            .:.:.||.||||..: ||.||:|.:..|.|..:
  Fly   648 --------------------------------PMSIENGEFSWGDEI-TLRNINIEVKKGSLVAL 679

Mouse   701 VGQVGCGKSSLLLAILGEMQTLEGKVYWNNVNESEPSFEATRSRSRYSVAYAAQKPWLLNATVEE 765
            ||.||.||||::.|.||||:.|.|.|  |.|.:               :||..|:.|:.||||.:
  Fly   680 VGTVGSGKSSVVQAFLGEMEKLAGVV--NTVGK---------------LAYVPQQAWIQNATVRD 727

Mouse   766 NITFGSPFNRQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIV 830
            ||.||..::|:||..|.|||:|:.|||:|..||.|||||:||||||||:|||.:|||:|.:.::.
  Fly   728 NILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLY 792

Mouse   831 FLDDPFSALDIHLSDHLMQE-----GILKFLQDDKRTVVLVTHKLQYLTHADWIIAMKDGSVLRE 890
            .||||.||:|.|:..|:.:|     |||.     :::.|||||.:.:|...|.|..:|.|.:...
  Fly   793 LLDDPLSAVDAHVGKHIFEEVIGPKGILA-----RKSRVLVTHGVTFLPQVDSIYVIKMGEISES 852

Mouse   891 GT------------------LKDIQTKDVELYEHWKTLMNRQD-QEL----EKDMEADQT----- 927
            ||                  |::...::.||.:..:.:.:..| .||    ||.::..:|
  Fly   853 GTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSD 917

Mouse   928 ---------------TLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEEDNMSTVMRLRTKMPWK 977
                           :|.|:|.|:..:...|.|....:.:|.|.:..|.:...|     ..:.:.
  Fly   918 SISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQT-----GGVEFA 977

Mouse   978 TCWWYLTSGGFFLLFLMIFSKLLKHSVIVAIDYWLATWTSEYSI-NHPGKADQTFYVAG-FSILC 1040
            ....|:.|.|.||....:....:..:..:..:.||..|.::.:: |..|..|....|.| |..
  Fly   978 VYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTGLRDMYLGVYGAFGF-- 1040

Mouse  1041 GAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPI-RFFDTTPLGLILNRFSADTNIIDQHI 1104
            |.|: |.....:.|...|..|||.:|:.||..||.|.: ||||.||:|.:||.||.|.:::|:.:
  Fly  1041 GQGV-LAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEEL 1104

Mouse  1105 PPTLESLTRSTLLCLSAIGMISYATPVFLVALAPLGVAFYFIQKYFRVASKDLQELDDSTQLPLL 1169
            |.|::|......:.|:.|.:||.:||:||..:.|:...:||.|:::...|:.|..|:..::.|:.
  Fly  1105 PATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIY 1169

Mouse  1170 CHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASI- 1233
            .|||||..|.:||||:....||.:......|.|.:.......|||||.:|.:.:|..|:|.||:
  Fly  1170 SHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLF 1234

Mouse  1234 ASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSF-LTMESENYEGTMDPS 1297
            |.:.|.:|.|||||.:.|||.:|..|||:||..:|:|..:.:|:::..: .|.:...:|...|.:
  Fly  1235 AVLGGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKN 1299

Mouse  1298 QVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDI 1362
            : |::|||||.::..:..|||...|..||:.|...|:.|:||||.||||:|||||:||.||:::.
  Fly  1300 K-PKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEA 1363

Mouse  1363 FDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDP-ECKCTDDRLWEALEIAQLKN 1426
            ..|:|.|||:||:.:.||.|||||:||.|||:|||||:|.|||| |.| |||.:|:|||::.||:
  Fly  1364 AGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIK-TDDEIWKALELSHLKS 1427

Mouse  1427 MVKSLPGGLDATVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTA 1491
            .||||..||:..:.|||||.|||||||.|||||.:||:.:|::|||||::|:.|::::||.:.|.
  Fly  1428 FVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTE 1492

Mouse  1492 FADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQEDGVFASFVR 1543
            |.:.||:|||||::|||.:|.|||:.:|.|:|:.:|..||......|.|..:
  Fly  1493 FKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAK 1544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abcc9	NP_035641.1	MRP_assoc_pro	23..1543	CDD:188098	528/1651 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	941..964		5/22 (23%)
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	531/1675 (32%)
		ABC_membrane	338..601	CDD:279056	92/278 (33%)
		ABCC_MRP_domain1	649..848	CDD:213217	99/221 (45%)
		ABC_membrane	988..1260	CDD:279056	94/274 (34%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	121/220 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841666
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.640