DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Abcc8 and MRP

DIOPT Version :9

Sequence 1:XP_036008753.1 Gene:Abcc8 / 20927 MGIID:1352629 Length:1597 Species:Mus musculus
Sequence 2:NP_723772.2 Gene:MRP / 34686 FlyBaseID:FBgn0032456 Length:1549 Species:Drosophila melanogaster


Alignment Length:1534 Identity:486/1534 - (31%)
Similarity:760/1534 - (49%) Gaps:256/1534 - (16%)


- Green bases have known domain annotations that are detailed below.


Mouse   147 FITKTIKFVKFYDHAIGFSQLRFCLTGLLVILY----GMLLLVEINVIRVRRYIFFKTPREVK-- 205
            |..:..:||.|:        :.|..|.:::||.    ||                   ||:.|  
  Fly   181 FSWEEYQFVSFF--------IFFTFTSIMLILNCFADGM-------------------PRQTKYQ 218

Mouse   206 -PPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHRKPI------DLRAIGKLPIAMRALTNY 263
             ...::.:|...|       ||:.||.|.:......:|.|:      |||........|....::
  Fly   219 RGENEIPELSASF-------LSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHH 276

Mouse   264 --QRLCAAFDAQARKDTQSQ-------------------QGARAIWRALCHAFGRRLVLSSTFRI 307
              |.:...:..:||.:.::|                   :|..:|...:..:||...:..:..::
  Fly   277 WNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKL 341

Mouse   308 LADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQ----EFLGNAYVLAVLLFLALLL 368
            ..|.|.||                   ||:...|.:.||.:|    |:.|..|  |||||: |..
  Fly   342 FTDTLTFA-------------------QPQVLSLIISFVEAQDAEPEWKGILY--AVLLFV-LAA 384

Mouse   369 QRTFLQASYYVAI-ETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFF 432
            .:||:...|:..: ..|:.:|.|:...||.|.:.:  ||.:..|.|.|:|.||:|:|..:.|...
  Fly   385 AQTFILGQYFHRMFIVGLRIRTALINAIYRKALRI--SNSTKKESTVGEIVNLMAVDAQRFMELT 447

Mouse   433 FLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLK 497
            .....:|:.|:||.:.:..|:..||.|.|.|.||:|:|.||...:|:::...|...::|.:||:|
  Fly   448 TYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVK 512

Mouse   498 QTNEMLRGIKLLKLYAWENIFCSRVEMTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLITFVGH 562
            ..||:|.|||:|||||||..|..:|...|.||:.:||:.|...:.:.|:.:..|....|:||..:
  Fly   513 LMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATY 577

Mouse   563 VSFFKESDFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQCAPR 627
            |...:.:..|......|::||.::..||.:|..:.....:..|||.::::||:|.|:........
  Fly   578 VLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSVLHD 642

Mouse   628 EPAPQGQAGKYQAVPLKVVNRKRPAREEVRDLLGPLQRLTPSMDGDADNFCVQIIGGFFTWTPDG 692
            ...|.         |:.:.|                                    |.|:| .|.
  Fly   643 SSKPH---------PMSIEN------------------------------------GEFSW-GDE 661

Mouse   693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQRVSGAVFWNSSLPDSEGEDPRYCLRT 757
            | ||.||.|.:.:|.|..:||.||.||||::.|.||||::::|.|                    
  Fly   662 I-TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVV-------------------- 705

Mouse   758 SNPERETAADSDARSRGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILP 822
                         .:.|.:||..|:.|:.||||.:||.|...::::||..||:||:|:.|||||.
  Fly   706 -------------NTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILS 757

Mouse   823 HGDQTQIGERGINLSGGQRQRISVARALYQHTNVVFLDDPFSALDVHLSDHLMQ-----AGILEL 882
            .||.|:|||:||||||||:||||:|||:|...::..||||.||:|.|:..|:.:     .|||. 
  Fly   758 AGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILA- 821

Mouse   883 LRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQ----LFEHWKTLMNRQDQ 943
                :::.|||||.:.:||..|.|..:|.|.|...||.....:::..    :.:|.:. .|.:::
  Fly   822 ----RKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQE-GNEEEE 881

Mouse   944 EL---EKETVMERKAPEPSQGLPRA--------------MSSRDGLL------------LDEDEE 979
            ||   :::.......||....:.:|              ::|.|.|:            .|..:.
  Fly   882 ELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDS 946

Mouse   980 EEEAAESEEDDNLSSVLHQRAK-----IPWRACTKYLSSAGVLLLSLLVFSQLLKHMVLVAIDYW 1039
            ...||..::...:...|.:..|     :.:.....|:.|.|:.|....:....:.....:..:.|
  Fly   947 VASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLW 1011

Mouse  1040 LAKWTDSALVLSPAARNCSLSQECALDQSVYAMVFTVLCSLGI---ALCLVTSVTVEWTGLKVAK 1101
            |.:|.:              .|..|.|..:..|...|..:.|.   .|.....|.|...|.:.||
  Fly  1012 LTQWAN--------------DQNVANDTGLRDMYLGVYGAFGFGQGVLAYFAVVIVYLGGFQAAK 1062

Mouse  1102 RLHRSLLNRIILAPM-RFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALTVISY 1165
            .:|..||..||...: |||:.||:|.:||.||.|.:.:|:.:|:|::.......:.::.:.|||.
  Fly  1063 TIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISL 1127

Mouse  1166 VTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQ 1230
            .||:||..::|:|.:.||.|:::...||.|.:|:..::.|:.|||:|||.|.:||||:....||.
  Fly  1128 STPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFI 1192

Mouse  1231 QKLLEYTDSNNIASLFLTAANRWLEVRMPGPAAVLPQEYIGACVVLIAAATSISNSLHRELSAGL 1295
            ::.....|.|.:.......|||||.:|:         |.:|..::|.|:..::   |..:.:.||
  Fly  1193 EESDAKVDKNQVCKYPSVIANRWLAIRL---------EMVGNLIILFASLFAV---LGGQTNPGL 1245

Mouse  1296 VGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHTLLKTEAESYEGLLAPSLIPKNWPDQGKI 1360
            |||.::|||.|:..|||:||..:|:|..:.:|:||....:|:.|:...|......|||||.:|::
  Fly  1246 VGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRV 1310

Mouse  1361 QIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDI 1425
            :.||..|||...|..||:.|:..|..|:|:||.||||:||||.:||.||:::...|||.|||:||
  Fly  1311 EFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDI 1375

Mouse  1426 AKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAII 1490
            |.:.||.|||||:||.||||||||::|.||||.:..:|..:|:|||::.||..||:|..||:..|
  Fly  1376 ASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEI 1440

Mouse  1491 TEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRV 1555
            .|||||.|.|||||.|||||.:|||.:.::|||||::|:.|::::||.:.|.|.:.||:|||||:
  Fly  1441 AEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRL 1505

Mouse  1556 HTILSADLVMVLKRGAILEFDKPEKLLSQKDSVFASFVR 1594
            :|||.:|.|:||.:|.|:||..|.:||....|.|.|..:
  Fly  1506 NTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAK 1544

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Abcc8XP_036008753.1 MRP_assoc_pro 224..1594 CDD:188098 471/1448 (33%)
MRPNP_723772.2 MRP_assoc_pro 14..1548 CDD:188098 486/1534 (32%)
ABC_membrane 338..601 CDD:279056 92/286 (32%)
ABCC_MRP_domain1 649..848 CDD:213217 96/274 (35%)
ABC_membrane 988..1260 CDD:279056 87/297 (29%)
ABCC_MRP_domain2 1308..1528 CDD:213211 119/219 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167841686
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.650

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