DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bhlhe40 and cwo

DIOPT Version :9

Sequence 1:	NP_035628.1	Gene:	Bhlhe40 / 20893	MGIID:	1097714	Length:	411	Species:	Mus musculus
Sequence 2:	NP_524775.1	Gene:	cwo / 44669	FlyBaseID:	FBgn0259938	Length:	698	Species:	Drosophila melanogaster

Alignment Length:	427	Identity:	96/427 - (22%)
Similarity:	142/427 - (33%)	Gaps:	147/427 - (34%)

- Green bases have known domain annotations that are detailed below.

Mouse    44 KRSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALT 108
            :|::.|::. .|.||:|||:||||:|.|:|.|..|:|...:....|.:||..::|:.::|:|
  Fly    55 RRNKTSRQD-PLSHRIIEKRRRDRMNSCLADLSRLIPPQYQRKGRGRIEKTEIIEMAIRHLK--- 115

Mouse   109 NLIDQQQQKIIALQSGLQ------------------AGDLSGRNLEAGQEMF----------C-- 143
            :|..:.|||....:||..                  ...|.||..|...|||          |
  Fly   116 HLQSECQQKESDYRSGYMDCMKEAAKFLYDVHMQDFCHRLLGRLQEHIDEMFKTDCYKSTRSCHM 180

Mouse   144 -------SG----------------FQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVSELLQG 185
                   ||                ..|.|.:| ::...|.:.:||.....:..|.|     .|.
  Fly   181 PDNVSASSGSPHQAYHPPLCHLRDMLATSASDV-EHSQDHNDVKDLSFRNHLNQLQR-----SQQ 239

Mouse   186 GASRKPLDSAPKAVDLKEKPSFLAKGSEGPGKNC-----VPVIQRTFAPSGGEQSGS-------- 237
            .|:...:.:|..||         |.|| .|..|.     ||:      .:||...|:
  Fly   240 AAAAAAVAAAAVAV---------ANGS-SPASNAGVDSKVPL------TNGGGTGGAPPAADNVP 288

Mouse   238 DTDTDSGYGGELEKGDLRSEQPYFKSDHGRRFAVGERVSTIKQESEEPPTKKSRMQLSEEEGHFA 302
            ...|.||.......|:..|.              |...|.....:..||.              .
  Fly   289 SNSTGSGSAAACAGGNSNSS--------------GSNSSNAASSTICPPA--------------G 325

Mouse   303 GSDLMGSPFLGPH--PHQPPFCLPFYLIPPSATA------YLPMLEKCWYPTSVPVLYPGLNTSA 359
            ||.......|..|  |||.|..        ::||      :.......:..:..|:|:
  Fly   326 GSCPAKVTPLAAHQQPHQAPVI--------TSTAPHHHHHHTDSSHHDFESSREPILH------- 375

Mouse   360 AALSSFMNPDKIPTPLLLPQRLPSPLAHSSLDSSALL 396
            ...|:..:|.  |..|||.|.  ..||||.....:|:
  Fly   376 TDTSNMHSPP--PRDLLLQQH--PHLAHSHHTQDSLM 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bhlhe40	NP_035628.1	Essential for interaction with ARNTL/BMAL1, E-box binding and repressor activity against the CLOCK-ARNTL/BMAL1 heterodimer. /evidence=ECO:0000250	1..139		34/112 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		bHLH-O_DEC1	40..129	CDD:381592	30/102 (29%)
		Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000250	75..79		1/3 (33%)
		ORANGE	140..184	CDD:128787	14/78 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..294		19/99 (19%)
cwo	NP_524775.1	HLH	66..118	CDD:306515	21/54 (39%)
cwo	NP_524775.1	ORANGE	126..168	CDD:128787	8/41 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830933
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740