DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bhlhe40 and E(spl)m5-HLH

DIOPT Version :9

Sequence 1:	NP_035628.1	Gene:	Bhlhe40 / 20893	MGIID:	1097714	Length:	411	Species:	Mus musculus
Sequence 2:	NP_524511.1	Gene:	E(spl)m5-HLH / 43158	FlyBaseID:	FBgn0002631	Length:	178	Species:	Drosophila melanogaster

Alignment Length:	171	Identity:	36/171 - (21%)
Similarity:	67/171 - (39%)	Gaps:	50/171 - (29%)

- Green bases have known domain annotations that are detailed below.

Mouse    54 KLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQKI 118
            |:...|:|::||.|:|:|:..||.|:.|......:..::||.:||..|..::   ..:.:||..:
  Fly    20 KVKKPLLERQRRARMNKCLDTLKTLVAEFQGDDAILRMDKAEMLEAALVFMR---KQVVKQQAPV 81

Mouse   119 IALQSGLQAGDLSGRNLEAGQEMFCSGFQTCAREVLQYLA--------------KH---ENTRDL 166
            ..|.                .:.|.:|:.....|:.:.:|              .|   |..|.|
  Fly    82 SPLP----------------MDSFKNGYMNAVSEISRVMACTPAMSVDVGKTVMTHLGVEFQRML 130

Mouse   167 KSSQLVTHL--------------HRVVSELLQGGASRKPLD 193
            ::.|:.|.:              :...:|..|..||.||::
  Fly   131 QADQVQTSVTTSTPRPLSPASSGYHSDNEDSQSAASPKPVE 171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bhlhe40	NP_035628.1	Essential for interaction with ARNTL/BMAL1, E-box binding and repressor activity against the CLOCK-ARNTL/BMAL1 heterodimer. /evidence=ECO:0000250	1..139		20/84 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		bHLH-O_DEC1	40..129	CDD:381592	20/74 (27%)
		Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000250	75..79		2/3 (67%)
		ORANGE	140..184	CDD:128787	11/74 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..294
E(spl)m5-HLH	NP_524511.1	HLH	20..72	CDD:238036	17/54 (31%)
E(spl)m5-HLH	NP_524511.1	ORANGE	87..131	CDD:128787	7/43 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830897
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840