DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bhlhe40 and h

DIOPT Version :9

Sequence 1:	NP_035628.1	Gene:	Bhlhe40 / 20893	MGIID:	1097714	Length:	411	Species:	Mus musculus
Sequence 2:	NP_001014577.1	Gene:	h / 38995	FlyBaseID:	FBgn0001168	Length:	337	Species:	Drosophila melanogaster

Alignment Length:	196	Identity:	58/196 - (29%)
Similarity:	85/196 - (43%)	Gaps:	57/196 - (29%)

- Green bases have known domain annotations that are detailed below.

Mouse    59 LIEKKRRDRINECIAQLKDLLPEHLKLTTLGH--LEKAVVLELTLKHVKALTNLIDQQQQKIIAL 121
            ::||:||.|||.|:.:||.|:.:..|.....|  ||||.:||.|:||::.|     |:||  .|:
  Fly    38 IMEKRRRARINNCLNELKTLILDATKKDPARHSKLEKADILEKTVKHLQEL-----QRQQ--AAM 95

Mouse   122 QSGLQAGDLSGRNLEAGQEMFCSGFQTCAREV--------------LQYLAKHENTRDLKSSQLV 172
            |   ||.|....|      .|.:||..|..||              ||:|:...|       .:.
  Fly    96 Q---QAADPKIVN------KFKAGFADCVNEVSRFPGIEPAQRRRLLQHLSNCIN-------GVK 144

Mouse   173 THLHRVVSELLQGGASRKPLDSAPKAVDLKEKPSFLAKGSEGP---GKNCVPVIQRT----FAPS 230
            |.||:...:..|.....:.|.|.|.:.:...:     :|:..|   |      ||:|    |.|:
  Fly   145 TELHQQQRQQQQQSIHAQMLPSPPSSPEQDSQ-----QGAAAPYLFG------IQQTASGYFLPN 198

Mouse   231 G 231
            |
  Fly   199 G 199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bhlhe40	NP_035628.1	Essential for interaction with ARNTL/BMAL1, E-box binding and repressor activity against the CLOCK-ARNTL/BMAL1 heterodimer. /evidence=ECO:0000250	1..139		32/81 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		bHLH-O_DEC1	40..129	CDD:381592	30/71 (42%)
		Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000250	75..79		2/3 (67%)
		ORANGE	140..184	CDD:128787	13/57 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..294		9/32 (28%)
h	NP_001014577.1	HLH	29..88	CDD:238036	22/49 (45%)
h	NP_001014577.1	ORANGE	106..141	CDD:128787	9/34 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910