Protein Alignment Daam1 and Frl

DIOPT Version :10

• Sequence 1: NP_080378.2
• Gene: Daam1 / 208846
• MGIID: 1914596
• Length: 1077
• Species: Mus musculus
• Sequence 2: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Alignment Length: 1248
• Identity: 309/1248 - (24%)
• Similarity: 528/1248 - (42%)
• Gaps: 344/1248 - (27%)

Mouse    30 LRNDSNFALQ---TMEPAL------PMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKKWQI 85
            ||.|...:.|   ..:|:|      |||..:|||..|::::..:||.....:.:.....||||.:
  Fly    52 LRYDIGCSSQYQHVRQPSLRSRSQQPMPTTDELDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDM 116

Mouse    86 YCSKKKDQEENKGATSWPEFYIDQLNS----MAARKSLLAL-----EKEE---EEERSKTIESLK 138
            .|.::..|.::.     |..|:.:|.:    .|:|...|.|     :|.:   |...::.:..|:
  Fly   117 ICDQEMVQAKDP-----PSHYLSKLRTYLDPKASRSHRLYLFYFLCQKRKMVGESTSTQVLRDLE 176

Mouse   139 TALRTKPMRFVTRFID-----LDGLSCILNF-LKTMDYE-------------------------- 171
            .:|||..:.:|..|:|     ||.|...|:| |:.|.:|
  Fly   177 ISLRTNHIEWVKEFLDDTNQGLDALVDYLSFRLQMMRHEQRLQGVLCASEERLNLTNGGDGGEIV 241

Mouse   172 -----------------------------TSESR------------------------------- 176
                                         |.:||
  Fly   242 MGNSSSVSPGGGGGLLSHGNSTGHGLANGTLDSRQQHTMSYGFLRPTIADALDSPSLKRRSRHIA 306

Mouse   177 ----------IHTSLIGCIKALMNNSQGRAHVLAHSESINVIAQSLSTENIKTKVAVLEILGAVC 231
                      ||.|:: |::|:|||..|...|:.|.|:||.||.||..::::||..|||:|.|:|
  Fly   307 KLNMGAATDDIHVSIM-CLRAIMNNKYGFNMVIQHREAINCIALSLIHKSLRTKALVLELLAAIC 370

Mouse   232 LVPGGHKKVLQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVE 296
            ||.|||:.:|.:..:::....|:.|||||   ::.........:....|.|.|:|.|:.   .||
  Fly   371 LVKGGHEIILGSFDNFKDVCQEKRRFQTL---MEYFMNFEAFNIDFMVACMQFMNIVVH---SVE 429

Mouse   297 SLDFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSAT 361
            .:::|:||:|||..||               ||::|:
  Fly   430 DMNYRVHLQYEFTALG---------------LDKYLE---------------------------- 451

Mouse   362 QMFELTRRRLTHSEAYPHFMSILHHCLQMPYKRSGNTVQYWLLLDRIIQQIVIQNDKGQDPDSTP 426
                  |.|||.||..                    .||....||.:.....:..|  .:..::.
  Fly   452 ------RIRLTESEEL--------------------KVQISAYLDNVFDVAALMED--SETKTSA 488

Mouse   427 LENFNIKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMK 491
            ||               .|::.::|.|:....::|...|..:.|.|......|:|:    |..::
  Fly   489 LE---------------RVQELEDQLEREIDRNSEFLYKYAELESESLTLKTEREQ----LAMIR 534

Mouse   492 EKLEKETT------EHKQVKQQVADLTAQLHELNRRAVCAAVPGGPSPG----APGGPF--PSSG 544
            :|||:|.|      :|.:.:.:..|.......:..:.:..::|...|.|    |.||..  .:||
  Fly   535 QKLEEELTVMQRMLQHNEQELKKRDTLLHTKNMELQTLSRSLPRSASSGDGSLANGGLMAGSTSG 599

Mouse   545 LGSL-LPPPPPPL-----LSGGALPPPPPPLPPGGPPPP-------------------------- 577
            ..|| |||||||:     .|..|.||||||.||..||||
  Fly   600 AASLTLPPPPPPMPASPTASSAAPPPPPPPAPPAPPPPPGFSPLGSPSGSLASTAPSPPHAPPML 664

Mouse   578 ----PGPPPLGGVLPPPGAPVSLTLKKKNIPQPTN-ALKSFNWSKLPENKLDGTVWTEIDDTKVF 637
                |.|||:.|.:|.|..  ::|:|:|   .||. .|.:.||..|..|::.||::.|:||.|:|
  Fly   665 SSFQPPPPPVAGFMPAPDG--AMTIKRK---VPTKYKLPTLNWIALKPNQVRGTIFNELDDEKIF 724

Mouse   638 KILDLEDLERTF-----SAYQRQQEFFVNNSKQKEADAIDDTLSSKLKVK---ELSVIDGRRAQN 694
            |.:|..:.|..|     .|.:       |.|...|   :|.:|.|..:.|   .:|:::..|.:|
  Fly   725 KQIDFNEFEERFKIGIGGALR-------NGSNGTE---VDGSLQSSKRFKRPDNVSLLEHTRLRN 779

Mouse   695 CNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEH---KHELDRMAKA 756
            ..|...:|.:..|::..||.::|.:: |..:.:|.|.|.||..:::...:|:   :.:...:.:.
  Fly   780 IAISRRKLGMPIDDVIAAIHSLDLKK-LSLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEE 843

Mouse   757 DRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSRALKQLLEVVLAFGN 821
            |:|:.::||:.....:|..:.:...|.:.|..:.|:|::|...|..:.:||..|.:||:||||||
  Fly   844 DKFMLQLSRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGN 908

Mouse   822 YMNKGQRGNAYGFKISSLNKIADTKSSIDKNITLLHYLITIVENKYPKVLNLSEELRDIPQAAKV 886
            |:|..:||.|||||:.||:.:.||||: ||..:||||::..:..|:|::||...||....:||.|
  Fly   909 YLNSNKRGPAYGFKLQSLDTLIDTKST-DKRSSLLHYIVATIRAKFPELLNFESELYGTDKAASV 972

Mouse   887 NMTELDKEISTLRSGLKAV--ETELEYQKSQPPQPGDKFVSVVSQFITLASFSFSDVEDLLAEAK 949
            .:..:..::..|..|:..|  |.||..:.:|        ..::..|:..:......::..|..|:
  Fly   973 ALENVVADVQELEKGMDLVRKEAELRVKGAQ--------THILRDFLNNSEDKLKKIKSDLRHAQ 1029

Mouse   950 ELFTKAVKHFGEEAGKIQPDEFFGIFDQFLQ-------------------AVAEAKQENENMRKR 995
            |.|.:.|::||:.:.......||.:..:|.:                   |:|.:|:||:.:..|
  Fly  1030 EAFKECVEYFGDSSRNADAAAFFALIVRFTRAFKQHDQENEQRLRLEKAAALAASKKENDQVLMR 1094

Mouse   996 KEEEERRARL---------EAQLKEQRERERKVRKAKESSEE---SGEFDDLVSALRSGEVFDKD 1048
            .:..:::.:|         ||.:.|.:.:...||:.|...::   :|..:|::..|:| |.:.:.
  Fly  1095 NKVNQKKQQLPSNGALSLQEAVINELKSKAHSVREKKLLQQDEVYNGALEDILLGLKS-EPYRRA 1158

Mouse  1049 LSKLKRNRKRISN 1061
            .:..:..|:||.|
  Fly  1159 DAVRRSQRRRIDN 1171

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Daam1	NP_080378.2	Drf_GBD	45..232	CDD:461886	68/306 (22%)
		Drf_FH3	235..439	CDD:461885	41/203 (20%)
		PRK12704	444..>513	CDD:237177	17/74 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	457..478		4/20 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	526..596		38/111 (34%)
		FH2	600..982	CDD:396655	113/414 (27%)
		Actin-binding. /evidence=ECO:0000250	693..702		2/8 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1007..1033		6/28 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1056..1077		4/6 (67%)
Frl	NP_729954.2	Drf_GBD	77..371	CDD:461886	67/299 (22%)
		Drf_FH3	374..567	CDD:461885	58/288 (20%)
		FH2	687..1063	CDD:396655	114/398 (29%)