Protein Alignment Daam1 and capu

DIOPT Version :10

• Sequence 1: NP_080378.2
• Gene: Daam1 / 208846
• MGIID: 1914596
• Length: 1077
• Species: Mus musculus
• Sequence 2: NP_001137784.1
• Gene: capu / 33611
• FlyBaseID: FBgn0000256
• Length: 1361
• Species: Drosophila melanogaster
• Alignment Length: 1189
• Identity: 274/1189 - (23%)
• Similarity: 442/1189 - (37%)
• Gaps: 327/1189 - (27%)

Mouse    40 TMEPAL-----PMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKKWQIYCSKKKDQEENKG- 98
            ||||..     |:...|..:|..::.|:..:|:.:...|:...|..     ..|...::....|
  Fly   327 TMEPCAAGSGSPLANGELFNVSKAKKVELQNLSSRFTAAVTQTPPG-----VTSSTPNESGVTGP 386

Mouse    99 ------ATSWPEFYIDQLNSMAARKSLLALEKEEEEERSKTIESLKTA---LRTKPMRFVTRFID 154
                  .||.|.........::.:.|...::.:.....|:.:|. .||   |...|..|.|....
  Fly   387 AGPLGATTSSPSLETQSTVIISFKSSQTPVQSQTNSAASENVED-DTAPLPLPPPPPGFGTPTTP 450

Mouse   155 LDGLSCILNFLKTMDYETSESRIHTSLIGCIKALMNNSQGRAHVLAHSESINVIA----QSLSTE 215
            |  ||.  |.||    :.:...:..|..|      |||....::...|:...::|    .||:..
  Fly   451 L--LSS--NVLK----KVASFTVEKSSAG------NNSSNPPNLCPTSDETTLLATPCSSSLTVA 501

Mouse   216 NIKTKVAVLEILGAVCLVPGGHK--KVLQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVSLK 278
            .:..::||....|.|....|..:  ..:...|.:..|  |:...|.||..| .||.:...:.|..
  Fly   502 TLPPEIAVGAAAGGVAGGAGSRRGSSYVPEKLSFAAY--EKFEGQMLIKWL-ISTMQSNPKSSSG 563

Mouse   279 TAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDE 343
            .|.....|.:        :|.|..:|:|    :|:      |::..|..||.....:||
  Fly   564 DANQELFNTL--------ALQFCNNLKY----VGV------LKQISNEHLDCGFSPYEM------ 604

Mouse   344 LEFAKRFELVHIDTKSATQMFELTRRRLTHSEAYPHFMSI-----------------------LH 385
                  ::..|  |:..|....||..:|....|:| |.|.                       |.
  Fly   605 ------YQWTH--TEQPTTSLPLTPGKLDKVAAWP-FSSTPSGIRALESASLASLGAGGVAGSLA 660

Mouse   386 HCLQMPYKRSGNTVQYWLLLDRIIQQIV---------------IQNDKGQDPDSTPLENFNIKNV 435
            .........|.|        .:.:|||:               :.|:.....|..|..  ..|..
  Fly   661 TIATASTASSDN--------QKTLQQILKKRLLNCTTLAEVHAVVNELLSSVDEPPRR--PSKRC 715

Mouse   436 VRM--LVNENEVKQW---KEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLE 495
            |.:  |:|.:|...:   |..||...|...:.:.:.|.::.|...|..:....:......||..|
  Fly   716 VNLTELLNASEATVYEYNKTGAEGCVKSFTDAETQTESEDCEGTCKCGQSSTKVSDNESAKEDGE 780

Mouse   496 KETTEHKQVKQQVADLTAQLHELNRRAVCAAVPGGPSP----GAPGGPFPSSGLGSLLPPPPPPL 556
            |.                       .||....|..|.|    .||..|.|..      |||||||
  Fly   781 KP-----------------------HAVAPPPPPPPPPLHAFVAPPPPPPPP------PPPPPPL 816

Mouse   557 LSGGALPPPPPPLPPGG----PPPPPGPPPLGGVLPPPGAPVSLTLKKKNI-----PQP------ 606
            .:.|| ||||||.|||.    |||||.|...||.:|||..|:|.:..|..|     |.|
  Fly   817 ANYGA-PPPPPPPPPGSGSAPPPPPPAPIEGGGGIPPPPPPMSASPSKTTISPAPLPDPAEGNWF 880

Mouse   607 --TNALKS-----------FNWSKL----------PE--NKLDGT-------------------- 626
              ||.::.           ..|:::          |.  |..|.|
  Fly   881 HRTNTMRKSAVNPPKPMRPLYWTRIVTSAPPAPRPPSVANSTDSTENSGSSPDEPPAANGADAPP 945

Mouse   627 --------VWTEIDDTKVFKILDLEDLERTFSAYQRQQEFFVNNSKQKEADAIDDTLSSKLKV-- 681
                    :||||::|      .|::::.....:.||.  ....||.||           |||
  Fly   946 TAPPATKEIWTEIEET------PLDNIDEFTELFSRQA--IAPVSKPKE-----------LKVKR 991

Mouse   682 -KELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEE 745
             |.:.|:|..|::|..|:...|.:.:.||:.||..:|..        ...|:.:...|:|...|:
  Fly   992 AKSIKVLDPERSRNVGIIWRSLHVPSSEIEHAIYHIDTS--------VVSLEALQHMSNIQATED 1048

Mouse   746 HKHELDRMAKA----------DRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSGS 800
               ||.|:.:|          ::||.::|.|:...:|:..:.|:.:|.|.|..:..|:|.:...|
  Fly  1049 ---ELQRIKEAAGGDIPLDHPEQFLLDISLISMASERISCIVFQAEFEESVTLLFRKLETVSQLS 1110

Mouse   801 EEVFRSRALKQLLEVVLAFGNYMNKG--QRGNAYGFKISSLNKIADTKSSIDKNITLLHYLI-TI 862
            :::..|..||.:..::|..|||||.|  |||.|.||.:..|.|:.|.||. :.:.||||::: |.
  Fly  1111 QQLIESEDLKLVFSIILTLGNYMNGGNRQRGQADGFNLDILGKLKDVKSK-ESHTTLLHFIVRTY 1174

Mouse   863 V-----ENKYPKVLNLS-EELRDIPQAAKVNMTELDKEISTL-RSGLKAVETELEYQKSQPPQPG 920
            :     |..:|..:.|. .|..|:.:||:::..|:.::|..| :..|....|..:...:..|:..
  Fly  1175 IAQRRKEGVHPLEIRLPIPEPADVERAAQMDFEEVQQQIFDLNKKFLGCKRTTAKVLAASRPEIM 1239

Mouse   921 DKFVSVVSQFITLASFSFSDVEDLLAEAKELFTKAVK--HFGEEA-----GKIQPDEFFGIFDQF 978
            :.|.|.:.:|:..|..|.:.:...|.|.::||.:.::  ||..:|     .:..||:||..:..|
  Fly  1240 EPFKSKMEEFVEGADKSMAKLHQSLDECRDLFLETMRFYHFSPKACTLTLAQCTPDQFFEYWTNF 1304

Mouse   979 LQAVAEA-KQE-----NENMRKRKEEEERRARLEAQLKEQRERERKVRKAKESSEESGEFDDLVS 1037
            .....:. |:|     ||.|:|.|         :||::.:|....||.|
  Fly  1305 TNDFKDIWKKEITSLLNELMKKSK---------QAQIESRRNVSTKVEK---------------- 1344

Mouse  1038 ALRSGEVFDKDLSKLKRNR 1056
               ||.:..|:...::|::
  Fly  1345 ---SGRISLKERMLMRRSK 1360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Daam1	NP_080378.2	Drf_GBD	45..232	CDD:461886	40/205 (20%)
		Drf_FH3	235..439	CDD:461885	45/245 (18%)
		PRK12704	444..>513	CDD:237177	12/71 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	457..478		4/20 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	526..596		37/77 (48%)
		FH2	600..982	CDD:396655	114/475 (24%)
		Actin-binding. /evidence=ECO:0000250	693..702		2/8 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1007..1033		6/25 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1056..1077		0/1 (0%)
capu	NP_001137784.1	FH2	888..1315	CDD:214697	109/457 (24%)