back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERN1 and Ern1

DIOPT Version :9

Sequence 1:	XP_016879836.1	Gene:	ERN1 / 2081	HGNCID:	3449	Length:	1014	Species:	Homo sapiens
Sequence 2:	NP_076402.1	Gene:	Ern1 / 78943	MGIID:	1930134	Length:	977	Species:	Mus musculus

Alignment Length:	964	Identity:	897/964 - (93%)
Similarity:	928/964 - (96%)	Gaps:	2/964 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    51 PHGFEIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPN 115
            |.|...||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    16 PPGPGSFGRTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPN 80

Human   116 DGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAF 180
            ||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    81 DGSLYTLGGKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAF 145

Human   181 ADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYKMSHFVSNGDGLVVT 245
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   146 ADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYKMSHFVSNGDGLVVT 210

Human   246 VDSESGDVLWIQNYASPVVAFYVWQREGLRKVMHINVAVETLRYLTFMSGEVGRITKWKYPFPKE 310
            |||||||||||||||||||||||||.|.||||:||||||||||||||||||||||||||||||||
Mouse   211 VDSESGDVLWIQNYASPVVAFYVWQGEVLRKVVHINVAVETLRYLTFMSGEVGRITKWKYPFPKE 275

Human   311 TEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPST 375
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   276 TEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPST 340

Human   376 DVKFDPGLKSKNKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEV 440
            |:|||||||.|:|||||||||||||||||||||||||||||||||||||||||||||||:|||||
Mouse   341 DLKFDPGLKGKSKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKRSFEEV 405

Human   441 INLVDQTSENAPTTVSRDVEEKPAHAPARPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSM 505
            ||:|.|||:|.|||||:|||||.|.|||:||||||||||||||||||||||:||||||||||||:
Mouse   406 INIVGQTSDNTPTTVSQDVEEKLARAPAKPEAPVDSMLKDMATIILSTFLLVGWVAFIITYPLSV 470

Human   506 HQQQQLQHQQFQKELEKIQLLQQQQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRAS 570
            |||:|||||||||||||||||  |||||||||.||..||.|.||:|||:||||||||||.|||||
Mouse   471 HQQRQLQHQQFQKELEKIQLL--QQQQLPFHPHGDLTQDPEFLDSSGPFSESSGTSSPSPSPRAS 533

Human   571 NHSLCSGSSASKAGSSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAV 635
            ||||...||||:||:||||||||.||||.:||||||||||||||||||||||||:||||||||||
Mouse   534 NHSLHPSSSASRAGTSPSLEQDDEDEETRMVIVGKISFCPKDVLGHGAEGTIVYKGMFDNRDVAV 598

Human   636 KRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGL 700
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   599 KRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGL 663

Human   701 EPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRR 765
            ||||||.|||||||||||||||||||||||||:|||||||:||||||||||||||||||||||||
Mouse   664 EPITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRR 728

Human   766 SGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLD 830
            ||||||||||||||||||||:||||||||||||||||||||||:||||||||||||||||||:||
Mouse   729 SGVPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGNHPFGKSLQRQANILLGACNLD 793

Human   831 CLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPI 895
            |.|.:||||||||||||||||||||:|||||||||||||||||||||||||||||||||:|||||
Mouse   794 CFHSDKHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKEALDGPI 858

Human   896 VKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLG 960
            |:|||||||||||||||||||||||||||||||||||||||||||||||||||||||.||:||||
Mouse   859 VRQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPVEVQETLG 923

Human   961 SLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFHEPPEPQPPVTPDAL 1014
            |:|||||.||||||||||:|||:|||||.||||||.||:|||.||||||.|.||
Mouse   924 SIPDDFVRYFTSRFPHLLSHTYQAMELCRHERLFQTYYWHEPTEPQPPVIPYAL 977

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.