back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERN1 and ern1

DIOPT Version :10

Sequence 1:	NP_001424.3	Gene:	ERN1 / 2081	HGNCID:	3449	Length:	977	Species:	Homo sapiens
Sequence 2:	NP_001410601.1	Gene:	ern1 / 553551	ZFINID:	ZDB-GENE-050522-431	Length:	1031	Species:	Danio rerio

Alignment Length:	964	Identity:	700/964 - (72%)
Similarity:	806/964 - (83%)	Gaps:	13/964 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     3 ARRLLLLLTLLL----PGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQ 63
            :|.|:.::|.|:    .||..|.|:|||::||:|||||||||:||||||.:|:||||||||||||
Zfish     7 SRALVWIITALIWWSHSGLMGFCSSSTVSVPESLLFVSTLDGNLHAVSKISGTIKWTLKEDPVLQ 71

Human    64 VPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVI 128
            |||||.||||||||||||||:||.||||||||||||||||||||||||||||||||||||:|||:
Zfish    72 VPTHVSEPAFLPDPNDGSLYSLGGKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDVWYVV 136

Human   129 DLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDY 193
            |||||||:|||:|::|:.||||:||.|||||||||||||||:|||||||||.|||.:||::|..|
Zfish   137 DLLTGEKKQTLTSSYAEMLCPSSSLFYLGRTEYTITMYDTKSRELRWNATYSDYAFTLPDEDTKY 201

Human   194 KMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKVMHINVAVETLRYLTFMSG 258
            .|:||||||||||||||||||||.|:|||.|||||.|:|||||||||.|.|||||||||||||||
Zfish   202 NMAHFVSNGDGLVVTVDSESGDVQWVQNYNSPVVAVYIWQREGLRKVPHTNVAVETLRYLTFMSG 266

Human   259 EVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDG 323
            ||||||:||||||:|.:.|.||..||||||:|:.||||||:||:||.|||||.|.|:||||...|
Zfish   267 EVGRITQWKYPFPREKKTKDKLLSTLYVGKHSSGLYASPSLVHDGVTVVPRGRTFPMLEGPGNQG 331

Human   324 VTIGDKGECVITPSTDVKFDPGLKSKNKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRE 388
            ....|:.||||||||.|.|:..||.:|::|::||..|||||||.|..|..|.||:||.::|:...
Zfish   332 SREEDEQECVITPSTTVNFNAALKERNRINFMRNSLLLIGHHEMPPDAHHKFLEKFPESIPRQNM 396

Human   389 NVIPADSEKKSFEEVINLVDQTSENAPTTVSRDVEEKPAHAPARPEAPVDSMLKDMATIILSTFL 453
            ||||..:||...|:|.....:.:...|..|| .::|||...| |.|.|||||||||||||..|||
Zfish   397 NVIPPATEKTIEEKVNESGMEDNSPLPPPVS-SLQEKPGRVP-RVETPVDSMLKDMATIIFCTFL 459

Human   454 LIGWVAFIITYPLSMHQQQQLQHQQFQKEL-EKIQLLQQQQQQLPFHPPGDTAQDGELLDTSGPY 517
            |.|||||:||||.|:|:||||||||||::: ||:|||  |:|||.|.||.|...|.:.|:.:...
Zfish   460 LAGWVAFVITYPKSVHKQQQLQHQQFQQQMEEKLQLL--QRQQLIFQPPTDLPPDSDFLEAARTR 522

Human   518 SESSGTSSPSTSPRASNHSLCSGSSASKAGSSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAE 582
            ||||..|||:.:||||||   |..|..:.|.|.: |.:|.:||:::|.:|.|:|.||:|||||||
Zfish   523 SESSTHSSPNGTPRASNH---SNISQCETGHSAN-EHEDTEEESNIVRIGNITFNPKNVLGHGAE 583

Human   583 GTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA 647
            |||||||.||||.|||||||||||||||||||||||||||||||||||||:||||||||||||.:
Zfish   584 GTIVYRGQFDNRPVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTERDRQFQYIAIELCNS 648

Human   648 TLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDF 712
            |||||||:|||...||||:|||:||.||||||||||||||||||||||:||||.||::|||||||
Zfish   649 TLQEYVERKDFNRHGLEPVTLLEQTMSGLAHLHSLNIVHRDLKPHNILVSMPNMHGRVKAMISDF 713

Human   713 GLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGK 777
            |||||||||||||||:|||||||||||||:||||.|.|||..|||||||||||||:|||.|||||
Zfish   714 GLCKKLAVGRHSFSRKSGVPGTEGWIAPEVLSEDAKHNPTCMVDIFSAGCVFYYVVSEGFHPFGK 778

Human   778 SLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFF 842
            ||||||||||||.|||.|.|.:||.::||.|||:|:.|:|:|||||..||||||||||||||.||
Zfish   779 SLQRQANILLGAYSLDHLDPNRHESIVARNLIEQMLNMEPEKRPSADRVLKHPFFWSLEKQLHFF 843

Human   843 QDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNK 907
            ||||||||||.||||||:|||||||.|||.|||::|||||||||||||:||||||||||||||||
Zfish   844 QDVSDRIEKEPLDGPIVRQLERGGRVVVKGDWRDHITVPLQTDLRKFRSYKGGSVRDLLRAMRNK 908

Human   908 KHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYY 961
            ||||||||.:|::|||::||:||.|||||||.||.||:.||..|:.||.|.|||
Zfish   909 KHHYRELPEDVQQTLGTIPDEFVFYFTSRFPLLLQHTHLAMRYCAVERSFLPYY 962

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.