DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERN1 and Ire1

DIOPT Version :9

Sequence 1:	XP_016879836.1	Gene:	ERN1 / 2081	HGNCID:	3449	Length:	1014	Species:	Homo sapiens
Sequence 2:	NP_001097839.1	Gene:	Ire1 / 42358	FlyBaseID:	FBgn0261984	Length:	1074	Species:	Drosophila melanogaster

Alignment Length:	1028	Identity:	393/1028 - (38%)
Similarity:	556/1028 - (54%)	Gaps:	192/1028 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    67 ETLLFVSTLDGSLHAVSKRTGSIKWTLKEDP--VLQVPTHVEEPAFLPDPNDGSLYTLGSKNNEG 129
            |.|:..|||.|.|.|:...|..|:||:.:||  |.:...:|:.|.|||||.|||:|.||...:
  Fly    53 EALMVFSTLGGGLTAIDPVTSEIRWTIADDPPIVAEHQENVQVPHFLPDPRDGSIYQLGQMGS-- 115

Human   130 LTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLC--------- 185
            |.|||:|||:||..:||||||||||.|||.|.||::|..||.:::.:  .|.|:..
  Fly   116 LKKLPYTIPQLVANAPCRSSDGILYSGKKSDTWYMVDPKTGRREKVM--GFGDATVDGKEGEQIG 178

Human   186 -PSTSLLYLGRTEYTITMYDT--KTRELR-WNATYFDYAA--SLPEDDVDYKMSHFVSNGDGLVV 244
             .::..:|||||:||:.|||:  |.::.: ||.|::||.|  :.||...:|:..|..:..:|.:|
  Fly   179 WATSRAIYLGRTQYTVMMYDSLAKNKDAKPWNITFYDYNAVSAPPELAKEYEYIHLTTTTNGQIV 243

Human   245 TVDSESGDVLWIQNYASPVVAFYVWQREGLRKVMHINVAVETLRYLTFMS--GEVGRITKWKYPF 307
            |:|.:.|..||.::.:|||||.::...:||..|....|:.|..:.:...|  |.|..:
  Fly   244 TLDRKHGKFLWQRDLSSPVVAAFLLGPDGLLSVPFTTVSDEAYQAILEESKTGNVNTV------- 301

Human   308 PKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLP---LLEGPQTDGVTIGDKGEC 369
                    ||..:||||::...|||.||:|.:.   .||.||.|   ||:||      .||:
  Fly   302 --------KLFQSLYVGEHQKGLYALPSLVDKN---TPRISTAPPIKLLDGP------TGDQ--- 346

Human   370 VITPSTDVKFDPGLKSKNKLNYLRNY-----WLLIGHHE-----------TPLSASTKMLERFPN 418
                :::.:.||      :..|:.:.     .:::||:.           :|.:||:|:::....
  Fly   347 ----NSNQETDP------RTIYINDVLQEHAGIMLGHYNMPNEGNGNLQLSPTTASSKVVQSLAT 401

Human   419 NLPKHREN---VIPADSEKKSFE-------EVINL-VDQ-----TSENAPTTVSRDVEEKPAHA- 466
               .|..|   .:.|::||.:.:       |::.: :||     |.....|.:.::..:..|..
  Fly   402 ---IHNYNDGYGLLANNEKNAADIGVQTDPELVEIGIDQRTNGNTINRTKTIILQNSNKVQAFIN 463

Human   467 ---PARPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQKELEKIQLLQQ 528
               ...|...|..:|         ..:::|.:| :..|..|.           .:||:|
  Fly   464 EWFMEHPSGKVHQIL---------IVIVLGMIA-LFWYTCST-----------MRELQK------ 501

Human   529 QQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSGSSASKAGSSPSLEQDD 593
                                      ...:|:.:.:.:...||.|  :||:.|.|.:...::..:
  Fly   502 --------------------------QSENGSKTFAIAQNGSNGS--TGSNGSNANAEDLVDLGN 538

Human   594 GDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDE 658
            |.     |.||||||...:|||.|.|||.|::|.|:.|.|||||:|||||:||||||.||||||.
  Fly   539 GQ-----VRVGKISFSTNEVLGKGCEGTFVFKGTFEERFVAVKRLLPECFTFADREVALLRESDA 598

Human   659 HPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHL--GLEPITLLQQTTSGLAHLHSLNI 721
            |.||:||||||:||||:|||:||||||||:|.|......|  .::...:|.|..|||:|||||:|
  Fly   599 HENVVRYFCTEQDRQFRYIAVELCAATLQDYTEGDRSLELQNHIDVWQVLSQAASGLSHLHSLDI 663

Human   722 VHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKE 786
            ||||:||.|:|||:|:|.||::.|||||||||||..|:.||||||||.||:|||||||:.   .:
  Fly   664 VHRDIKPQNVLISLPDAKGKVRVMISDFGLCKKLNFGKTSFSRRSGVTGTDGWIAPEMMR---SQ 725

Human   787 NPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHED----VIARELIE 847
            ..|..|||||.|||:|||:|.|.|.||.:|:||||||....:|..|.||...:    ::|.:||.
  Fly   726 RTTTAVDIFSLGCVYYYVLSGGHHAFGDNLKRQANILSHEYNLAKLRPEDDSEDSRIILAEQLIS 790

Human   848 KMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWR 912
            .||..|||.||.|:.:..||.||...|.|.|.||||||:||.......:|.||:.||.||..||.
  Fly   791 DMIHKDPQSRPPARCIGNHPLFWDEPKMLSFLQDVSDRVEKLQFHAEPLKSLEKNGRIVVLDDWN 855

Human   913 ENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHL 977
            .::...:..||||:|.|.|.||||||||:|||||||.||....::.||.:|.:|..|:..|||.|
  Fly   856 VHLDPMITDDLRKYRGYMGASVRDLLRALRNKKHHYHELTPAAQKMLGCIPHEFTNYWVDRFPQL 920

Human   978 LAHTYRAMELCSHERLFQPYY-----FHEP----------------PEPQPPV 1009
            ::|.|.|..:||:|.:|:|||     |..|                |:|.|.:
  Fly   921 ISHAYHAFSICSNEPIFKPYYSAGYLFTRPWYFDADDALFPMLMLDPKPLPKI 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERN1	XP_016879836.1	None
Ire1	NP_001097839.1	Luminal_IRE1	53..321	CDD:188875	108/286 (38%)
		STKc_IRE1	545..813	CDD:270884	159/270 (59%)
		S_TKc	552..812	CDD:214567	155/262 (59%)
		RNase_Ire1	817..941	CDD:199217	61/123 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	308	1.000	Domainoid score	I1345
eggNOG	1	0.900	-	-		E2759_KOG1027
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55580
Inparanoid	1	1.050	651	1.000	Inparanoid score	I791
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48078
OrthoDB	1	1.010	-	-		D1019877at2759
OrthoFinder	1	1.000	-	-		FOG0001857
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102150
Panther	1	1.100	-	-	O	PTHR13954
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2163
SonicParanoid	1	1.000	-	-		X1217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870