Protein Alignment AKT2 and for

DIOPT Version :10

• Sequence 1: NP_001617.1
• Gene: AKT2 / 208
• HGNCID: 392
• Length: 481
• Species: Homo sapiens
• Sequence 2: NP_477487.1
• Gene: for / 44817
• FlyBaseID: FBgn0000721
• Length: 1088
• Species: Drosophila melanogaster
• Alignment Length: 467
• Identity: 137/467 - (29%)
• Similarity: 228/467 - (48%)
• Gaps: 58/467 - (12%)

Human     3 EVSVIKEGWLHKRGEYIKTWRPR---YFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMK 64
            ::|.:.|...::||:||.....|   :|::......:..|::....::.:..|........:.::
  Fly   649 KISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQDTQEEKFIRMLGKGDFFGEKALQ 713

Human    65 TERPRPNTFV------IRCLQWTTVIER-TFHVDSPDEREEWMRAIQMVAN--SLKQRAPGEDPM 120
            .:..|....:      :.||    ||:| ||:              |:::|  .:|.|...|..|
  Fly   714 GDDLRTANIICESADGVSCL----VIDRETFN--------------QLISNLDEIKHRYDDEGAM 760

Human   121 DYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKA-TGRYYAMKILR 184
            :.:       ...||..        .:.:.|...:..||.|.||:|.||:... :.|.:|:|.::
  Fly   761 ERR-------KINEEFR--------DINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMK 810

Human   185 KEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTE 249
            |..|:...:..|.::|..::......|:..|...|:....|..:||...||||:..|..:..|.:
  Fly   811 KSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDD 875

Human   250 ERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTP 314
            ...|||.|.:|.|.:|||||:::|||:|.|||:|::.|::|:.|||..|: :..|....||||||
  Fly   876 STTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKK-LQTGRKTWTFCGTP 939

Human   315 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELIL--MEEIRFPRTLSPEA 377
            ||:||||:.:..:..:.|:|.|||:|:|::.|..||...|..|.:.:||  ::.|.|||.::..|
  Fly   940 EYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNA 1004

Human   378 KSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDE 442
            .:|:..|.:.:|.:|||.......|:.:|::|....|..:....|.||.||.|.|.|||..|||
  Fly  1005 SNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDD- 1068

Human   443 FTAQSITITPPD 454
                    .|||
  Fly  1069 --------YPPD 1072

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AKT2	NP_001617.1	PH_PKB	4..111	CDD:269947	20/118 (17%)
		STKc_PKB_beta	156..478	CDD:173686	110/302 (36%)
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374
		CAP_ED	520..629	CDD:237999
		CAP_ED	638..754	CDD:237999	21/122 (17%)
		STKc_cGK	783..1043	CDD:270724	94/260 (36%)