Protein Alignment AKT2 and Pka-C2

DIOPT Version :10

• Sequence 1: NP_001617.1
• Gene: AKT2 / 208
• HGNCID: 392
• Length: 481
• Species: Homo sapiens
• Sequence 2: NP_733397.2
• Gene: Pka-C2 / 43644
• FlyBaseID: FBgn0000274
• Length: 354
• Species: Drosophila melanogaster
• Alignment Length: 305
• Identity: 118/305 - (38%)
• Similarity: 182/305 - (59%)
• Gaps: 15/305 - (4%)

Human   157 LLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQT 221
            :||.|:||.|:|||||:...|||.|::.||.::...:|||...|..||...|.|||..|..:.:.
  Fly    50 VLGNGSFGTVMLVREKSGKNYYAAKMMSKEDLVRLKQVAHVHNEKHVLNAARFPFLIYLVDSTKC 114

Human   222 HDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKD 286
            .|.|..::...||||||.:..|.|.|.|:.||||.|::..||||:|...::|||:|.||::||:.
  Fly   115 FDYLYLILPLVNGGELFSYHRRVRKFNEKHARFYAAQVALALEYMHKMHLMYRDLKPENILLDQR 179

Human   287 GHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF- 350
            |:|||||||..|.  .||.| .|.||||||||||:::...|.::||||..|:::||.:.||.||
  Fly   180 GYIKITDFGFTKR--VDGRT-STLCGTPEYLAPEIVQLRPYNKSVDWWAFGILVYEFVAGRSPFA 241

Human   351 -YNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINW 414
             :|:|...::..|.:.:.:.|...:.:.:||:..|::.|..:|||.....:.:|..|.:|..::|
  Fly   242 IHNRDVILMYSKICICDYKMPSYFTSQLRSLVESLMQVDTSKRLGNSNDGSSDVKSHPWFQGVDW 306

Human   415 QDVVQKKLLPPFKPQVTSEVDTRYFDD-EFTAQSITITPPDRYDS 458
            ..::.:::..|::|.::...|...|:: ||         .|||.|
  Fly   307 FGILNQEVTAPYQPTISGAEDLSNFENFEF---------KDRYKS 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AKT2	NP_001617.1	PH_PKB	4..111	CDD:269947
		STKc_PKB_beta	156..478	CDD:173686	118/305 (39%)
Pka-C2	NP_733397.2	Protein Kinases, catalytic domain	43..334	CDD:473864	112/286 (39%)