Protein Alignment AKT2 and CG12069

DIOPT Version :10

• Sequence 1: NP_001617.1
• Gene: AKT2 / 208
• HGNCID: 392
• Length: 481
• Species: Homo sapiens
• Sequence 2: NP_651819.1
• Gene: CG12069 / 43643
• FlyBaseID: FBgn0039796
• Length: 356
• Species: Drosophila melanogaster
• Alignment Length: 294
• Identity: 110/294 - (37%)
• Similarity: 178/294 - (60%)
• Gaps: 5/294 - (1%)

Human   149 MNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLT 213
            ::|::....||.|:||||.||||:.:|.|||.|.|.|:.|:...:|:|.::|..||::...|...
  Fly    44 LDDYEIKATLGSGSFGKVQLVRERESGVYYASKQLSKDQIVKTKQVSHVMSEKNVLRSMTFPNTV 108

Human   214 ALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKL 278
            .|..:::..|.|..|:....|||||.:..:.|.|||::||||.|::..||||||...::|||:|.
  Fly   109 NLIASYKDFDSLYLVLPLIGGGELFTYHRKVRKFTEKQARFYAAQVFLALEYLHHCSLLYRDLKP 173

Human   279 ENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEM 343
            ||:|:||:|::|:||||..|:  .:..|| |.|||||||.||:::...||.:||||..||:::|.
  Fly   174 ENIMMDKNGYLKVTDFGFAKK--VETRTM-TLCGTPEYLPPEIIQSKPYGTSVDWWAFGVLVFEF 235

Human   344 MCGRLPF--YNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEH 406
            :.|..||  :|:|...::..|...:.:.|...|...:.|:..||:.|..:|.|...:..:::.||
  Fly   236 VAGHSPFSAHNRDVMSMYNKICEADYKMPSYFSGALRHLVDHLLQVDLSKRFGNLINGNRDIKEH 300

Human   407 RFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFD 440
            .:|..:.|..::.:.:..|:.|.:::..|...||
  Fly   301 EWFKDVEWIPLLNQTVNAPYVPNISNPEDISNFD 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AKT2	NP_001617.1	PH_PKB	4..111	CDD:269947
		STKc_PKB_beta	156..478	CDD:173686	109/287 (38%)
CG12069	NP_651819.1	Protein Kinases, catalytic domain	45..335	CDD:473864	110/293 (38%)