Protein Alignment AKT2 and Pkn

DIOPT Version :10

• Sequence 1: NP_001617.1
• Gene: AKT2 / 208
• HGNCID: 392
• Length: 481
• Species: Homo sapiens
• Sequence 2: NP_001097237.1
• Gene: Pkn / 35950
• FlyBaseID: FBgn0020621
• Length: 1501
• Species: Drosophila melanogaster
• Alignment Length: 481
• Identity: 177/481 - (36%)
• Similarity: 265/481 - (55%)
• Gaps: 72/481 - (14%)

Human    47 QTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPD-----EREEWMRAIQMV 106
            :.:|.|....|...|....::..|   :|:.....|:...:....:|.     :|:|
  Fly  1040 EVIPQLGKLYVGSSQQQYAQQSSP---IIQEPATPTIYGNSAAAGAPQFPQPAQRQE-------- 1093

Human   107 ANSLKQRAPGEDPM---DYKCG-----------SPSDSSTTEEMEVAVSKAR------------- 144
                 ::.|.:.|:   .|:..           |||.|:|:...:....:.|
  Fly  1094 -----KQPPQQQPIYANQYELNVAKAAAAASVYSPSSSTTSNSNQQQQQQRRNVARGLQYRESGG 1153

Human   145 -------------AKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAH 196
                         ..::|::|..|.:||:|.||||||.:.::..:|||:|.|:|..|||:|||..
  Fly  1154 LETGRAGKQPPNAGMLSMDNFRLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIARDEVES 1218

Human   197 TVTESRVLQ---NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAE 258
            .::|.|:.:   ..|||||..|...|||...:|||||||.||:|..|:..: ||.|.||.||.|.
  Fly  1219 LLSEKRIFEVANAMRHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHIHTD-VFLEPRAVFYAAC 1282

Human   259 IVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLE 323
            :|..|:|||...::|||:||:||:||.:|::||.||||||||:..|....|||||||:||||||.
  Fly  1283 VVLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTGTFCGTPEFLAPEVLT 1347

Human   324 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKD 388
            :..|.||||||||||:::||:.|..||...|.|.:|:.|:.:|:|:||.||.||.:::..||:|:
  Fly  1348 ETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAVMRRLLRKN 1412

Human   389 PKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPP 453
            |::|||....||::|.:..||.||.|.|::.:|:.|||.|.:....|...||:|||::...:|||
  Fly  1413 PERRLGSSERDAEDVKKQAFFRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTSEKAQLTPP 1477

Human   454 --DRYDSLGLLELDQRTHFPQFSYSA 477
              .|:     |..:::..|..|||:|
  Fly  1478 KEPRH-----LTEEEQLLFQDFSYTA 1498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AKT2	NP_001617.1	PH_PKB	4..111	CDD:269947	10/68 (15%)
		STKc_PKB_beta	156..478	CDD:173686	155/327 (47%)
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012
		HR1_PKN_2	243..309	CDD:212013
		HR1_PKN_3	340..414	CDD:212015
		C2	530..611	CDD:472691
		STKc_PKN	1174..1499	CDD:270741	157/331 (47%)