Protein Alignment AKT2 and Pka-C1

DIOPT Version :10

• Sequence 1: NP_001617.1
• Gene: AKT2 / 208
• HGNCID: 392
• Length: 481
• Species: Homo sapiens
• Sequence 2: NP_476977.1
• Gene: Pka-C1 / 34284
• FlyBaseID: FBgn0000273
• Length: 353
• Species: Drosophila melanogaster
• Alignment Length: 326
• Identity: 134/326 - (41%)
• Similarity: 199/326 - (61%)
• Gaps: 11/326 - (3%)

Human   134 EEMEVAVSKARAKVT----MNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEV 194
            ||.|   .|.|...|    ::||:.:|.||.|:||:|::|:.|.|..|||||||.|:.::...:|
  Fly    27 EEFE---DKWRRNPTNTAALDDFERIKTLGTGSFGRVMIVQHKPTKDYYAMKILDKQKVVKLKQV 88

Human   195 AHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEI 259
            .||:.|.|:||..:.|||.:|:|.|:.:..|..|:||..|||:|.||.:...|:|..:|||.|:|
  Fly    89 EHTLNEKRILQAIQFPFLVSLRYHFKDNSNLYMVLEYVPGGEMFSHLRKVGRFSEPHSRFYAAQI 153

Human   260 VSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLED 324
            |.|.||||..|::|||:|.|||::|..|::|:||||..|.  ..|.|. |.||||||||||::..
  Fly   154 VLAFEYLHYLDLIYRDLKPENLLIDSQGYLKVTDFGFAKR--VKGRTW-TLCGTPEYLAPEIILS 215

Human   325 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDP 389
            ..|.:|||||.|||::|||..|..||:.....:::|.|:..::|||.....:.|.||..||:.|.
  Fly   216 KGYNKAVDWWALGVLVYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFGSDLKDLLRNLLQVDL 280

Human   390 KQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPD 454
            .:|.|...:...::...::|.|.:|..:.|||:..||.|:.....||..||| :..:::.|:..:
  Fly   281 TKRYGNLKAGVNDIKNQKWFASTDWIAIFQKKIEAPFIPRCKGPGDTSNFDD-YEEEALRISSTE 344

Human   455 R 455
            :
  Fly   345 K 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AKT2	NP_001617.1	PH_PKB	4..111	CDD:269947
		STKc_PKB_beta	156..478	CDD:173686	126/300 (42%)
Pka-C1	NP_476977.1	STKc_PKA	44..333	CDD:271111	127/292 (43%)