Protein Alignment AKT2 and sck1

DIOPT Version :10

• Sequence 1: NP_001617.1
• Gene: AKT2 / 208
• HGNCID: 392
• Length: 481
• Species: Homo sapiens
• Sequence 2: NP_593754.1
• Gene: sck1 / 2542492
• PomBaseID: SPAC1B9.02C
• Length: 696
• Species: Schizosaccharomyces pombe
• Alignment Length: 489
• Identity: 184/489 - (37%)
• Similarity: 263/489 - (53%)
• Gaps: 71/489 - (14%)

Human    32 DGSF---IGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQW--TTVIERT---- 87
            ||..   |..|.||.|...:    .:.|....:||..:        :||..|  .||.:.|
pombe   181 DGGIPISIPSKNRPLAGSAS----GSSSGLHSELMLAD--------VRCPHWDFETVFDVTKMKS 233

Human    88 ---FHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSK-----AR 144
               ..|....|.::::.::::....|.:..   ....||. .|.|.:.:.|.|:.|..     ..
pombe   234 QMVVSVYDKYEDDKFLGSVKITPIFLHEYV---QEAWYKL-EPLDLTKSLEGEIKVETIYEHIEH 294

Human   145 AKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNT-- 207
            .:....||..|:|:||||||:|.|||:..|.|.||||.:.|::|:.|.||.||:.|..:|..|
pombe   295 VRYGPEDFTALRLIGKGTFGQVYLVRKNDTNRIYAMKKISKKLIVRKKEVTHTLGERNILVRTSL 359

Human   208 -RHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDV 271
             ..||:..||::|||...|..:.:|.:|||||:||..|..|.|:||:||.||:|.|||:||..|:
pombe   360 DESPFIVGLKFSFQTASDLYLITDYMSGGELFWHLQHEGRFPEQRAKFYIAELVLALEHLHKHDI 424

Human   272 VYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEV-LEDNDYGRAVDWWG 335
            :|||:|.||::||.||||.:.||||.|..:|..||..|||||.||||||| |||..|.:.||:|.
pombe   425 IYRDLKPENILLDADGHIALCDFGLSKANLSANATTNTFCGTTEYLAPEVLLEDKGYTKQVDFWS 489

Human   336 LGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPR-TLSPEAKSLLAGLLKKDPKQRLGGGPSD 399
            |||:::||.||..|||..|.::::..|...::|||: .||.|.:|.:.|||.::|..|| |..:|
pombe   490 LGVLVFEMCCGWSPFYAPDVQQMYRNIAFGKVRFPKGVLSSEGRSFVRGLLNRNPNHRL-GAVAD 553

Human   400 AKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFT---AQSITI----------T 451
            ..|:.||.||..|||..:.:||:.|||||.|.:::|...||.|||   .::|.|          |
pombe   554 TTELKEHPFFADINWDLLSKKKVQPPFKPNVQNDLDVSNFDKEFTNTNVKNINIVSNVDPANAST 618

Human   452 P-------------------PDRYDSLGLLELDQ 466
            |                   .:::.:|||.|.::
pombe   619 PLSNTIQDRFRGFTFVNKSIDEQFQNLGLQENEE 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AKT2	NP_001617.1	PH_PKB	4..111	CDD:269947	18/90 (20%)
		STKc_PKB_beta	156..478	CDD:173686	155/348 (45%)
sck1	NP_593754.1	C2	139..294	CDD:472691	26/128 (20%)
		STKc_Sck1_like	308..633	CDD:270738	150/325 (46%)