DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Srebf2 and Mitf

DIOPT Version :9

Sequence 1:NP_150087.1 Gene:Srebf2 / 20788 MGIID:107585 Length:1130 Species:Mus musculus
Sequence 2:NP_001245436.1 Gene:Mitf / 3885647 FlyBaseID:FBgn0263112 Length:837 Species:Drosophila melanogaster


Alignment Length:527 Identity:101/527 - (19%)
Similarity:188/527 - (35%) Gaps:172/527 - (32%)


- Green bases have known domain annotations that are detailed below.


Mouse    52 SSFPGGGSNGGSGNNSSGRGNNGGATDPAVQRSFSQVPLSTF--SPSAASPQAPALQVKVSPTPP 114
            |.|...||....|:.||           ::::....|.:...  |.|.|..:.|...:.|.    
  Fly   222 SEFIDSGSTSACGSGSS-----------SLEQMSQLVQMDNLIDSSSGAKLKVPLQSIGVD---- 271

Mouse   115 RATPVLQPRPQPQPQPPAQLQQQTVMITPTFSTAPQTRIIQQP--LIYQNAATSFQVLQPQVQSL 177
                          .||..||..||:..||     :..:||:.  .:.|..:.||   :|.:...
  Fly   272 --------------VPPQVLQVSTVLENPT-----RYHVIQKQKNQVRQYLSESF---KPSMWGS 314

Mouse   178 VTSP-----------QVQPVTIQQQV-------------QTVQAQRVLTQTANGTLQTLAPATVQ 218
            .||.           .:|..::|:.:             ..|.|:|::   .:.....::|....
  Fly   315 HTSEIKLANNSASTGNLQNSSLQKGICDPLERTNRFGCDSAVSAKRIM---PSDDAMPISPFGGS 376

Mouse   219 TVAAPQVQQV-PVLVQPQ-----------------IIKTDSLVLTTLKTDG--SPVMAAVQNPAL 263
            .|....:..: |.:::|.                 :.|.:|.:.:|..:.|  :.:..:..:.:|
  Fly   377 FVRCDDINPIEPTVLRPNSHGAGEPENAHRTAQLGLSKANSSLSSTRSSSGIVNSIRISSTSSSL 441

Mouse   264 TALTAPIQTAALQVPTLVGSNGTILTTMPVMMG---------QEKVPIKQVPGGVKQLDP---PK 316
            .:.:|||..:...|.|.|.....|..  .::..         ..::.|||.|..:...:.   .|
  Fly   442 QSTSAPISPSVSSVATSVSEPDDIFD--DILQNDSFNFDKNFNSELSIKQEPQNLTDAEMNALAK 504

Mouse   317 EGERRTTHNIIEKRYRSSINDKIIELKDLV-MGTDA--------KMHKSGVLRKAIDYIKYLQQV 372
            :.:::..||:||:|.|.:|||:|.||..|: .|:||        :.:|..:|:.::||||.|:..
  Fly   505 DRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVVRDIRPNKGTILKSSVDYIKCLKHE 569

Mouse   373 NHKLRQENM---VLKLANQKNKLLKGIDLGSLVDSDVDLKIDDFNQNVLL--------------- 419
            ..:|||..:   .::|.|:|           |:....:|::...:..:||               
  Fly   570 VTRLRQNELRQRQVELQNRK-----------LMSRIKELEMQAKSHGILLSENHLTSLSAPTQPY 623

Mouse   420 -----MSPPASDS-----------------GSQAGFSPYSIDS---------EPGSPLLDD-AKV 452
                 :||.||.|                 |:........:|.         :.|.|:|.. :.:
  Fly   624 LKSFSLSPTASRSRRSLFDQPVEKKIQVIDGADGNMGMNQVDEFMEDCKYAVQGGDPMLSSHSHM 688

Mouse   453 KDEPDSP 459
            :..|.||
  Fly   689 QSAPQSP 695

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Srebf2NP_150087.1 Transcriptional activation (acidic). /evidence=ECO:0000250|UniProtKB:P36956 1..50
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 53..133 14/81 (17%)
Interaction with LMNA. /evidence=ECO:0000269|PubMed:11929849 226..480 65/325 (20%)
HLH 320..370 CDD:278439 22/58 (38%)
Leucine-zipper 369..390 6/23 (26%)
MitfNP_001245436.1 MITF_TFEB_C_3_N <272..>311 CDD:292573 14/46 (30%)
HLH 505..570 CDD:238036 23/64 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1708
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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