DRSC/TRiP Functional Genomics Resources

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Protein Alignment Srebf1 and Usf

DIOPT Version :9

Sequence 1:NP_035610.1 Gene:Srebf1 / 20787 MGIID:107606 Length:1134 Species:Mus musculus
Sequence 2:NP_572167.3 Gene:Usf / 31384 FlyBaseID:FBgn0029711 Length:437 Species:Drosophila melanogaster


Alignment Length:351 Identity:75/351 - (21%)
Similarity:119/351 - (33%) Gaps:112/351 - (31%)


- Green bases have known domain annotations that are detailed below.


Mouse   162 YSSLPSGFSGTLPGNTQQPPS-SLPLAPAPGVL----PT-PALHTQVQSLASQQPLPA---SAAP 217
            :|.|||...  ||.|.|.|.. .:.|....|.|    || .|:..::.:|:.:..||:   |::.
  Fly   117 HSLLPSNLQ--LPNNLQLPTGCEIYLVKETGSLMGEPPTKAAIKLELDTLSEKPLLPSVTTSSST 179

Mouse   218 RTNTVTSQVQQVPVVLQPHFIKADSLLLTAVKTDAGATVKTAGISTL--------APGTAVQAGP 274
            ::..:|:|....|:.             ..:.|....|..|...|.|        ..|.|.....
  Fly   180 QSAVITAQTVNPPIP-------------GNINTTTSTTSTTTTTSVLYGSHGNGHGHGHAHAQAR 231

Mouse   275 LQTLVSGGTILATVPLVVDTDKLPIHRLAAGSKALGSAQSRGEKRTA-HNAIEKRYRSSINDKIV 338
            .|...:|.|              |..:|.|..|       |.:||.| ||.:|:|.|..||..|.
  Fly   232 SQPESAGQT--------------PSSKLEAYKK-------RDDKRRATHNEVERRRRDKINSWIF 275

Mouse   339 ELKDLVVG-------TEAKL-------------------------------NKSAVLRKAIDYIR 365
            :||:::..       :||..                               :||.:|.||.:||:
  Fly   276 KLKEMLPSLSSSSSFSEASTSPSTSGSTSTNGSSHSKGNASSSSGRAPPNDSKSQILIKACEYIK 340

Mouse   366 FLQ-----------------HSNQKLKQENLTLRSAHKSKSLKDLVSACGSGGGTDVSMEGMKPE 413
            .:|                 .|||.|::|   |....:.:.|::.....|.....:|::..:...
  Fly   341 SMQGEIDTLRDCLRETDSLRASNQALREE---LDRLKRQQQLQERFHTAGGRSTFNVTLNSLNSS 402

Mouse   414 VVETLTPPPSDAGSPSQSSPLSFGSR 439
            ....|........:.:..|.|.||.|
  Fly   403 ATSDLFEGIDTTPNLAAVSSLGFGKR 428

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Srebf1NP_035610.1 Transcriptional activation (acidic). /evidence=ECO:0000250|UniProtKB:P36956 1..60
9aaTAD. /evidence=ECO:0000250|UniProtKB:P36956 27..35
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 46..73
ERbeta_N 114..210 CDD:289279 16/53 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 130..149
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 170..195 8/29 (28%)
Interaction with LMNA. /evidence=ECO:0000269|PubMed:11929849 227..487 54/277 (19%)
HLH 315..372 CDD:238036 25/112 (22%)
Leucine-zipper 367..388 7/37 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 415..468 6/25 (24%)
UsfNP_572167.3 HLH 255..343 CDD:278439 21/87 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1708
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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