Protein Alignment ERG and Ets65A

DIOPT Version :10

• Sequence 1: NP_001129626.1
• Gene: ERG / 2078
• HGNCID: 3446
• Length: 486
• Species: Homo sapiens
• Sequence 2: NP_001303373.1
• Gene: Ets65A / 38700
• FlyBaseID: FBgn0005658
• Length: 728
• Species: Drosophila melanogaster
• Alignment Length: 549
• Identity: 190/549 - (34%)
• Similarity: 250/549 - (45%)
• Gaps: 150/549 - (27%)

Human     6 PDPAAHIKE----ALSVVSED-------QSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVP 59
            |...|.:|.    ||...|.:       ||.||....:...||..: ...||.:|.:|..|....
  Fly    19 PPTLAQVKTEECLALGQCSPEWTSYRFHQSTFEQLKQSVEKAKAAL-QDRSSFFGASSAFSDIYS 82

Human    60 QQDWLSQPPARVTIKMECNPSQV-NGSRNSPDECSVAKGGKMVGSPDT----VG----MNYGSYM 115
            .|        |:|..::..|.|. ||            ||..:|.|..    ||    :||.:..
  Fly    83 SQ--------RLTDSLDTLPVQSGNG------------GGNCLGLPHNPNVGVGVAGVLNYNAVS 127

Human   116 E-------------EKH----MPPPN-----------MTTNERRV---------IVPADPTLW-- 141
            .             ::|    :.||:           :|::..:|         ..||.|:|.
  Fly   128 SSTAGVLSSSGNGVQRHRLDTLQPPSGCSPAVTQHGVITSSAGQVTSGTLDAVSAAPALPSLTAS 192

Human   142 STDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETP 206
            |:.||                          :...:..|......|.|.:|           ..|
  Fly   193 SSSHV--------------------------EHKVRADKSTLDCATTSSHA-----------AAP 220

Human   207 LPHLTSDDVDKALQNSPRLMHARNTGGAAFIF--PNTSVYPEATQRITTRPDLPYEPPRRSAWTG 269
            ....::.|..:...:..:..:...|||.|...  ..:::|..                .:|:|..
  Fly   221 SSSSSASDHQQGRISGSKSSNTSGTGGGASASGGGGSALYSS----------------YKSSWGS 269

Human   270 HGHPTPQSKAAQPSPSTVPKTEDQRPQL---DPYQILGPTSSRLANPGSGQIQLWQFLLELLSDS 331
            |.....|..    |.:.:....|...||   ||||:.||||||||:.||||||||||||||||||
  Fly   270 HSSTQSQGY----SSNALGIKHDPHSQLRQPDPYQMFGPTSSRLASSGSGQIQLWQFLLELLSDS 330

Human   332 SNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYK 396
            :|:|||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||
  Fly   331 NNASCITWEGTNGEFKLTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYK 395

Human   397 FDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFF--AAPNPY 459
            |||.|:|.|.||...:.: |||.||| :|..||...:..:|::|| ..:..:|:|.|  ||....
  Fly   396 FDFQGLAAATQPAASDPT-YKYQSDL-FMTPYHHSAKLSSFMSPH-HGMTSSSASIFPSAASWGN 457

Human   460 WNSPTGGIY-PN--TRLPTSHMPSHLGTY 485
            |.||...:| |:  :.:..||:..||.:|
  Fly   458 WGSPATNLYQPHSMSHVTPSHVAPHLSSY 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERG	NP_001129626.1	SAM_PNT-ERG	134..208	CDD:176090	12/75 (16%)
		ETS	317..400	CDD:197710	79/82 (96%)
Ets65A	NP_001303373.1	ETS	316..401	CDD:197710	80/84 (95%)