Protein Alignment ERG and aop

DIOPT Version :10

• Sequence 1: NP_001129626.1
• Gene: ERG / 2078
• HGNCID: 3446
• Length: 486
• Species: Homo sapiens
• Sequence 2: NP_523455.2
• Gene: aop / 33392
• FlyBaseID: FBgn0000097
• Length: 732
• Species: Drosophila melanogaster
• Alignment Length: 631
• Identity: 141/631 - (22%)
• Similarity: 217/631 - (34%)
• Gaps: 249/631 - (39%)

Human    74 KMECNPSQVNGSRNSPD-------ECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERR 131
            ||:..|.|::.:..:|.       .|..|...::.              |.|...||::
  Fly     3 KMKMLPVQLSLNSLNPGIWSDVLWRCPPAPSSQLA--------------ELKTQLPPSL------ 47

Human   132 VIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPS-----YN 191
               |:||.|||.:.|..:|.:.|:|:.||.::..||| ::||.||.:|:.||....|.     :|
  Fly    48 ---PSDPRLWSREDVLVFLRFCVREFDLPKLDFDLFQ-MNGKALCLLTRADFGHRCPGAGDVLHN 108

Human   192 A---DILLSHL--HYLRETPL---------PHL-----TSDDVDKALQNSPRLMHARNTGGAAFI 237
            .   .|:.||:  .:|..:|:         ||.     |...::...:|||....|.:..|..|:
  Fly   109 VLQMLIIESHMMQWHLPNSPVTPTSRYPLSPHSHPPTPTWPPLNAPPENSPFHSSAHSLAGHHFM 173

Human   238 FPNT---SVYPEATQRITTRPDLPYE---------------PPRRSAWTGHGHPTPQ------SK 278
            .||:   |..|....:.::.|..||:               .|.....|...:||..      |.
  Fly   174 APNSVTLSPPPSVDSQASSPPQAPYQNGGATGAAPGSAGGSAPAAGGATNTSNPTSSSASSTGSN 238

Human   279 AAQP------------------------------------------SPSTVPKTEDQRP------ 295
            .:||                                          ||...|..:|.:|
  Fly   239 GSQPNIMPMKGISSASSNHSDSEEEYSETSGGVSKMPPAPLSYSTASPPGTPILKDIKPNWTQQL 303

Human   296 ----------------------------QLDPYQI--------------LGPTSSRLANPGSGQI 318
                                        |...:|:              |..|:..:..|..|.|
  Fly   304 TNSFVNSWSQQQQQQQQQQAAAVAAVAAQAQQHQLQQQQQQQQLPQKLTLDNTAGPVVTPAGGSI 368

Human   319 Q----------------------------LWQFLLELLSDSSN--SSCITWE-GTNGEFKMTDPD 352
            .                            ||.||.:||:|.:.  |..|.|: ...|.||:.||.
  Fly   369 SAPTTPSYMYKAKREFFPENSEPNTNGRLLWDFLQQLLNDRNQKYSDLIAWKCRDTGVFKIVDPA 433

Human   353 EVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKF--------DFHGIAQALQPH 409
            .:|:.||.:|:..:|||||:||||||||..||:.||.|:|:.|:|        :...|:...|..
  Fly   434 GLAKLWGIQKNHLSMNYDKMSRALRYYYRVNILRKVQGERHCYQFLRNPTELKNIKNISLLRQST 498

Human   410 PPES-----SLYKYPSDLPYMGS---YHAHPQKMN---FVAPHPPA-------LPVTSSSFFAAP 456
            |...     |:.:..|..|  ||   .:.:||:.:   ..:|..||       ||..::...||.
  Fly   499 PANGNGGSPSMPQGSSQAP--GSPAGQNWNPQQQSQQQQQSPQRPASRNGPMSLPAVAAVAAAAA 561

Human   457 NPYWNSPTGGIY-------------------PNTRLPTSHMPSHLG 483
            ..|...||..::                   ||:  |..:.||.:|
  Fly   562 AAYGPPPTSPLFMHAINGAFHYLSAAAAGPPPNS--PALNTPSAVG 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERG	NP_001129626.1	SAM_PNT-ERG	134..208	CDD:176090	29/92 (32%)
		ETS	317..400	CDD:197710	41/121 (34%)
aop	NP_523455.2	SAM_PNT-Tel_Yan	49..116	CDD:176085	24/67 (36%)
		ETS	395..482	CDD:197710	40/86 (47%)