DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rnf43 and rnf150b

DIOPT Version :9

Sequence 1:	NP_766036.2	Gene:	Rnf43 / 207742	MGIID:	2442609	Length:	784	Species:	Mus musculus
Sequence 2:	NP_001017554.1	Gene:	rnf150b / 792211	ZFINID:	ZDB-GENE-050417-470	Length:	419	Species:	Danio rerio

Alignment Length:	215	Identity:	62/215 - (28%)
Similarity:	94/215 - (43%)	Gaps:	41/215 - (19%)

- Green bases have known domain annotations that are detailed below.

Mouse   125 KARMAGERGANAVLFDITEDRSAAEQLQQPLGLTKPVVLIW-----GSDAAKLMEFVYKNRKAYV 184
            |.|.|....|:||:.......:..|.:..|......||.|.     |.:...|||   :|...::
Zfish   119 KIRHAVGHNASAVVIFNVGSSNPNETITMPHQGISDVVAIMIPEPKGRELVLLME---RNITVHM 180

Mouse   185 WIELKEPPAGANYDVWILLTVVGTVFVIILASVLRI------------RCRPHHSRPDPLQQR-- 235
            .|.:    ...|...::..|.|  |||.|...:|.|            |.|..::| |..|:|
Zfish   181 HITI----GTRNLQKYVSRTSV--VFVSISFIILMIISLAWLVFYYIQRFRYANAR-DRNQRRLG 238

Mouse   236 --TARAISQLATRRYQAGCRRARAEWPDSGSSCSSTPVCAICLEEFSEGQELRVISCLHEFHRTC 298
              ..:|||||..|..:.|.:...:::.:          ||:|:|.:.....:|::.|.|.||:.|
Zfish   239 DAAKKAISQLQVRTIRKGDQETESDFDN----------CAVCIEGYKPNDVVRILPCRHLFHKCC 293

Mouse   299 VDPWLYQHRTCPLCMFNIVE 318
            |||||..|||||:|..||::
Zfish   294 VDPWLVDHRTCPMCKMNILK 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf43	NP_766036.2	zf-RING_2	270..312	CDD:290367	20/41 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..407
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..478
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..671
rnf150b	NP_001017554.1	PA_GRAIL_like	45..182	CDD:239037	16/65 (25%)
		UPF0233	<196..>221	CDD:299753	8/26 (31%)
		zf-RING_2	265..308	CDD:290367	20/52 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..419
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920