DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rnf43 and hrd1

DIOPT Version :9

Sequence 1:	NP_766036.2	Gene:	Rnf43 / 207742	MGIID:	2442609	Length:	784	Species:	Mus musculus
Sequence 2:	NP_596376.1	Gene:	hrd1 / 2539900	PomBaseID:	SPBC17D11.02c	Length:	677	Species:	Schizosaccharomyces pombe

Alignment Length:	458	Identity:	94/458 - (20%)
Similarity:	155/458 - (33%)	Gaps:	136/458 - (29%)

- Green bases have known domain annotations that are detailed below.

Mouse   168 DAAKLMEFVYKNRKA-YVWIELKEPPAGANYDVWILLTVVGTVFVIILASVLRIRCRPHHSRPDP 231
            :|:||..::|:.|.. .||.|      .:.|  ...|.|......::..|:|.:...|:.|.|
pombe   188 EASKLCIYLYEARHLDQVWDE------KSTY--LFRLEVCRDGLRLLAYSLLFMYQFPYVSVP-- 242

Mouse   232 LQQRTARAISQLAT------------RRYQAGCRRARAEWPDSGSS--CSSTPVCAICLEE---- 278
                 ..:|.|:.|            .|::...|...|.:|.:...  .:|...|.||.||
pombe   243 -----IYSIRQMYTCFYSLFRRIREHARFRQATRDMNAMYPTATEEQLTNSDRTCTICREEMFHP 302

Mouse   279 ------------FSEGQEL--RVISCLHEFHRTCVDPWLYQHRTCPLCMFNIVEGDSFSQAPAAS 329
                        ...|.::  :.:.|.|..|..|:..||.:.:|||:|..:::...|......||
pombe   303 DHPPENTDEMEPLPRGLDMTPKRLPCGHILHFHCLRNWLERQQTCPICRRSVIGNQSSPTGIPAS 367

Mouse   330 PSYQEPGRRLHLIRQHPGHAHYHLPSAYLLGPSRTSVARTPRPRPF--LPSQEPSMGSRHQR--- 389
            |:.    |...:..|.|...:....:| :.|.:.:|....|:...|  :|:...|..:.|.:
pombe   368 PNV----RATQIATQVPNPQNTPTTTA-VPGITNSSNQGDPQASTFNGVPNANSSGFAAHTQDLS 427

Mouse   390 --LPRTSHLRAPEEQQHLAVSPHPYAQGW------GLNRLRCTSQ-----HPAACPVALRRARPH 441
              :||...||                .||      |..|:...||     :|:|.|.
pombe   428 SVIPRRIALR----------------DGWTMLPIPGTRRIPTYSQSTSTTNPSATPT-------- 468

Mouse   442 ESSGSGESYCTERSGYLADGPASDSSSGPCHGSSSDSVVNCTDVSLQGIHG---------SSSTF 497
                :|:             |::.:..||....:|.:..|..    :||.|         ||:|.
pombe   469 ----TGD-------------PSNSTYGGPQTFPNSGNNPNFN----RGIAGIVPPGWRLVSSNTQ 512

Mouse   498 RSSLSSDFDPLVYCSPEGDLQGKGIQPSVTSRPRSL------DSVVPRGETQVSSHIHYHRHRHH 556
            ..|.:|....|...:...|.......|:|....|.|      .:..|...:.:||.:     |..
pombe   513 SLSTNSAMTSLYQNASSADNNLGSSLPNVVPLSRGLTQSNETSNTFPAASSNISSQL-----REL 572

Mouse   557 HYK 559
            |.|
pombe   573 HTK 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf43	NP_766036.2	zf-RING_2	270..312	CDD:290367	15/59 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..407		10/49 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..478		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..671		11/50 (22%)
hrd1	NP_596376.1	HRD1	1..514	CDD:227568	80/390 (21%)
hrd1	NP_596376.1	zf-RING_2	291..351	CDD:290367	15/59 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910