DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rnf43 and plr-1

DIOPT Version :9

Sequence 1:	NP_766036.2	Gene:	Rnf43 / 207742	MGIID:	2442609	Length:	784	Species:	Mus musculus
Sequence 2:	NP_499473.2	Gene:	plr-1 / 176575	WormBaseID:	WBGene00023404	Length:	487	Species:	Caenorhabditis elegans

Alignment Length:	478	Identity:	120/478 - (25%)
Similarity:	194/478 - (40%)	Gaps:	115/478 - (24%)

- Green bases have known domain annotations that are detailed below.

Mouse     6 QLQLAVLWPWLLMAT--LHA--GFGHTGRVLAAAVESERSAEQKAVIRV--IPLKMDPT-GKLNL 63
            :|.|.:|....|::|  :||  ...||      .:.|:....:||.|.|  ..:..|.| .:..:
Worm     2 RLLLFILLNTTLLSTNYVHARPSVSHT------TLASQFKFAEKADIFVTHTNINEDRTQDEKTI 60

Mouse    64 TLEGVFAGVAEVTPAEGKLMQSHPLYLCNASDD--DNLEPGFISIVKLESPRRAPRPCLSLASKA 126
            .|.|.|:.|.......|.::|......|:|...  ||.....:.:|..:...:....|::|.::|
Worm    61 KLSGTFSPVGSNYETGGDIVQVSSFRACDARRKGLDNTVFEHVPVVFYDDVEKFLTGCVALDNQA 125

Mouse   127 RMAGERGANAVLFDITEDRSAAEQLQQPL---GLTKPVVLIWGSDAAKL---------------- 172
            |.|.:.||.|:   |....|..|:..:|:   |...||:::......:|
Worm   126 RFAEKSGAMAL---IVGPASRVERTTRPMMIGGSKIPVIVLDDEQTERLRSELRSASERGAVTKL 187

Mouse   173 -MEFVYKNRKAYVWIELKEPPAGANYDVWILLTVVGTVFVII----LASVLRIRCRPHHSRPDPL 232
             :.|:.:.....:.:::..|..       :.:|::|.:.::|    |..|::|||:|...|...|
Worm   188 RISFIDEKPTKVLKLQVFRPTV-------LNITLLGLLIILIVFVSLLVVVKIRCQPTMHRELWL 245

Mouse   233 QQRTARAISQLATRRYQ------AGCRR------ARAEWPDSGSSCSSTPV-------------- 271
            :.....|::::..|.:|      ||.::      ||.:...|.||..|:.:
Worm   246 RALARTALTKMEIRSFQKEKNVEAGQKKKTSSTFARLKQHRSSSSRHSSYLAVFGSLTSVAQSSS 310

Mouse   272 ------CAICLEEFSEGQELRVISCLHEFHRTCVDPWLYQHRTCPLCMFNIV------------- 317
                  |.|||||:.||.||||:.|.||||..||||||...|.||||.|::|
Worm   311 HSAQERCVICLEEYEEGTELRVLFCGHEFHPKCVDPWLLSKRRCPLCQFDVVYKHYPKVDSPEKL 375

Mouse   318 ---EGDSFSQAPAASPSYQEP----GRRLHLIRQHPGHAHYHLPSAYLLGPSRTSVARTPRPRPF 375
               ..|:.|..|..|||...|    .|...|.|.: ...|:.:||:     :|.|..:.|..:|.
Worm   376 SGRSDDTTSLLPRTSPSEDLPSAPSSRSTRLTRPY-RTTHHLIPSS-----TRPSSHQRPSLQPT 434

Mouse   376 LPSQEPSMGSRHQRLPRTSHLRA 398
            .|        |.:..||...||:
Worm   435 AP--------RTRSCPRRRQLRS 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf43	NP_766036.2	zf-RING_2	270..312	CDD:290367	26/61 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..407		9/35 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..478
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..671
plr-1	NP_499473.2	zf-rbx1	305..358	CDD:289448	27/52 (52%)
plr-1	NP_499473.2	zf-RING_2	317..357	CDD:290367	26/39 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I6843
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138786at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto24902
orthoMCL	1	0.900	-	-		OOG6_118517
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4852
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.780