DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rnf43 and rnf215

DIOPT Version :9

Sequence 1:	NP_766036.2	Gene:	Rnf43 / 207742	MGIID:	2442609	Length:	784	Species:	Mus musculus
Sequence 2:	XP_005165127.1	Gene:	rnf215 / 101882431	ZFINID:	ZDB-GENE-060526-65	Length:	351	Species:	Danio rerio

Alignment Length:	373	Identity:	84/373 - (22%)
Similarity:	152/373 - (40%)	Gaps:	99/373 - (26%)

- Green bases have known domain annotations that are detailed below.

Mouse    10 AVLWPWL--LMATLHAGFGHT----------GRVLAAAVESERSAEQKAVIRVIPLKMDPTGKLN 62
            ||.|.|.  |:::....|...          |.|:..::|::              .||...|..
Zfish     9 AVCWLWFCPLVSSEQVAFVEVFLEDHQHILQGEVVQGSLEND--------------PMDNHSKKK 59

Mouse    63 LTLEGVFAGVAEVTPAEGKLMQSHPLYLCNASDDDNLEPG-FISIVKLE-------SPRRAPRPC 119
            ..|:|      |:...:.:.::|      |:..:|..:|. :|.:|.::       |........
Zfish    60 HGLKG------ELILVKDEALKS------NSEINDGKDPDPWIGVVPVQMEEGTVSSNSNQESFA 112

Mouse   120 LSLASKARMAGERGANAVLFDITEDRSAAEQLQQPLGLTKPVVLIWGSD-AAKLMEFVYKNRKAY 183
            .|:.:|.:.|...||:|::. :..:::...::.....|:||:::|..|: ..||:..:.:..:|.
Zfish   113 ASMVNKMKRALVLGASALII-LALNQNTVREMDLSQVLSKPIIVIQTSENVTKLIGALLRGLRAT 176

Mouse   184 VWIELK---EPPAGANYDVW--------------------------------------ILLTVVG 207
            ..|..|   :...||...:|                                      :|:.:|.
Zfish   177 AKITYKSFLQDSLGATLTLWSSCGRSRGGLYGEWQGVICTGETNSQVQKYLQQLWNTVVLVALVL 241

Mouse   208 TVFVIILASVLRIRCRPHHSRPD---PLQQRTARAISQLATRRYQAGCRRARAEWPDSGSSCSST 269
            :..||:.|   |.:.:.:....|   .|:|...:.:|.|.||.|    |:.:.....:.:....|
Zfish   242 STGVIVQA---RWQYQDNQFNDDLESNLKQDILKRLSALKTRTY----RQPKVRCDPTQTQTMET 299

Mouse   270 PVCAICLEEFSEGQELRVISCLHEFHRTCVDPWLYQHRTCPLCMFNIV 317
            ..||:|||:::..|.|||:.|||||||.||||||...:|||||..:::
Zfish   300 ESCAVCLEQYNNNQCLRVLPCLHEFHRDCVDPWLLLQQTCPLCKRSVL 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf43	NP_766036.2	zf-RING_2	270..312	CDD:290367	25/41 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..407
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..478
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..671
rnf215	XP_005165127.1	zf-RING_2	300..343	CDD:290367	26/42 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920