DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sptlc2 and lace

DIOPT Version :9

Sequence 1:	NP_035609.1	Gene:	Sptlc2 / 20773	MGIID:	108074	Length:	560	Species:	Mus musculus
Sequence 2:	NP_001285957.1	Gene:	lace / 34910	FlyBaseID:	FBgn0002524	Length:	597	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	288/543 - (53%)
Similarity:	393/543 - (72%)	Gaps:	20/543 - (3%)

- Green bases have known domain annotations that are detailed below.

Mouse     2 RPEPGGCCCRRPMRANGCVKNGEVRNGY---LRSSTATVAAAGQIHHVTENGGLYKRPFNE-AFE 62
            :|:|.. ..:.|...|...:...:.||:   |...:....|.|::....|:       |.: :||
  Fly    60 QPKPAN-DAQSPSSINYHPEKKSIPNGHASILDQESKPNQAEGKLSPELEH-------FQKTSFE 116

Mouse    63 ETPMLVAVLTYVGYGVLTLFGYLRDFLRHWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMR 127
            |.|:..|.|||:|:.:|.:.||:...|...::     |||: .:..:|:||..||:||:|.:|.|
  Fly   117 EVPLHTACLTYLGFYLLMILGYINQLLFVPKV-----ATEK-GRDGYVALYDAFESFYSRYVYRR 175

Mouse   128 IRDNWNRPICSVPGAKVDIMERKSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAE 192
            |:|.||||||||||.::.:.:|.:.||.||||:||...: .:|:|||||||||..||.|.:.:.|
  Fly   176 IKDCWNRPICSVPGDELTLKDRVTDDYGWSFKFTGTETR-CLNLGSYNYLGFAAATGQCADDSEE 239

Mouse   193 VLKEYGAGVCSTRQEIGNLDKHEELEKLVARFLGVEAAMTYGMGFATNSMNIPALVGKGCLILSD 257
            ..:..|...||:|.|:|:.::.:|||.|.||:.|||.|:.:|||||||::|:|:|:|...|::||
  Fly   240 SARSSGLAYCSSRCELGDNEQLQELEALTARYFGVEDAIVFGMGFATNALNLPSLLGPNSLVISD 304

Mouse   258 ELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQPRT-RRPWKKILILVEGIYSMEGS 321
            |.||||::||.||||||.::||||||:.||::|:..:.||.|:. .:||.|::||||||:|||||
  Fly   305 EKNHASIILGLRLSGATTKVFKHNNMRDLERVLRQGVCYGNPKKGGQPWDKVMILVEGIFSMEGS 369

Mouse   322 IVRLPEVIALKKKYKAYLYLDEAHSIGALGPSGRGVVDYFGLDPEDVDVMMGTFTKSFGASGGYI 386
            |||||||||||||||||||||||||:||:|..||||.|||.:||::||::|||||||||::|||:
  Fly   370 IVRLPEVIALKKKYKAYLYLDEAHSVGAMGSRGRGVTDYFNVDPKEVDILMGTFTKSFGSAGGYL 434

Mouse   387 GGKKELIDYLRTHSHSAVYATSMSPPVMEQIITSMKCIMGQDGTSLGKECIQQLAENTRYFRRRL 451
            .|.|:|||:|||:||:..||.|:|||:.:||:||||.|||:|||.:|::.|.|||.|||||||||
  Fly   435 AGSKKLIDFLRTNSHAHCYAASISPPIAQQILTSMKTIMGEDGTDIGRKKIHQLARNTRYFRRRL 499

Mouse   452 KEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTK 516
            .::|.|.||:|||||||:::|:.:||||..|.:..|:|..|..|||||||:|.|.||||||||||
  Fly   500 AQLGVITYGHEDSPVVPMLVYLFSKIGAVVRTLTTRHIAAVGAGFPATPIMEGRIRFCLSAAHTK 564

Mouse   517 EILDTALKEIDEVGDLLQLKYSR 539
            |.||.||:.|||:.|.|.|||||
  Fly   565 EQLDFALEAIDEIADDLGLKYSR 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sptlc2	NP_035609.1	PLN02483	65..540	CDD:178101	274/476 (58%)
Sptlc2	NP_035609.1	BioF	115..530	CDD:223234	251/415 (60%)
lace	NP_001285957.1	PLN02483	117..587	CDD:178101	273/476 (57%)
lace	NP_001285957.1	BioF	164..577	CDD:223234	250/413 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	469	1.000	Domainoid score	I453
eggNOG	1	0.900	-	-		E1_COG0156
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21610
Inparanoid	1	1.050	573	1.000	Inparanoid score	I1048
Isobase	1	0.950	-	0	Normalized mean entropy	S642
OMA	1	1.010	-	-		QHG53569
OrthoDB	1	1.010	-	-		D312139at33208
OrthoFinder	1	1.000	-	-		FOG0001517
OrthoInspector	1	1.000	-	-		otm42506
orthoMCL	1	0.900	-	-		OOG6_100700
Panther	1	1.100	-	-	LDO	PTHR13693
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R652
SonicParanoid	1	1.000	-	-		X956
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.820