DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sptbn1 and Actn

DIOPT Version :9

Sequence 1:NP_787030.2 Gene:Sptbn1 / 20742 MGIID:98388 Length:2363 Species:Mus musculus
Sequence 2:NP_001259165.1 Gene:Actn / 31166 FlyBaseID:FBgn0000667 Length:917 Species:Drosophila melanogaster


Alignment Length:1102 Identity:318/1102 - (28%)
Similarity:504/1102 - (45%) Gaps:280/1102 - (25%)


- Green bases have known domain annotations that are detailed below.


Mouse     1 MTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALADEREAVQKKTFTKWVN 65
            |...::.:|.:..::|:          ::|:.|......:|:.            ||||||.|.|
  Fly     3 MENGLSMEYGDGYMEQE----------EEWEREGLLDPAWEKQ------------QKKTFTAWCN 45

Mouse    66 SHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQFLKEQRVHL 130
            |||.:....|.::..|.|:|..|:.||||:|||.||||.:|:||.|.:.||:|||.|:..:.|||
  Fly    46 SHLRKAGTAIDNIEEDFRNGLKLMLLLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVHL 110

Mouse   131 ENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNI 195
            .::|:.:|||||.::|||:||||||||.||||||      |:.:||:.||||||.|||.|.|||:
  Fly   111 VSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISV------EEMTAKEGLLLWCQRKTAPYKNVNV 169

Mouse   196 HNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPED-ISVD 259
            .||..|::||:||.||||:|||||||:.||.|.|...||..||::||::|.:.::|||:| |:..
  Fly   170 QNFHLSFKDGLAFCALIHRHRPDLIDYAKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTP 234

Mouse   260 HPDEKSIITYVVTYYHYFSKMKALA----------------------VEGKRIGKVLDNAIETEK 302
            .|||::|:|||..|||.|...:.:.                      ....||.|||....|.|:
  Fly   235 KPDERAIMTYVSCYYHAFQGAQQVGNVTHVPEPTRQYTYVPNNYNAETAANRICKVLKVNQENER 299

Mouse   303 MIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLF 367
            ::|:||.|||||||||.:|:..||:|:..|||.|||::|:.:.|||...|||:..:|..||....
  Fly   300 LMEEYERLASDLLEWIRRTMPWLNSRQADNSLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFN 364

Mouse   368 TIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAA 432
            |:|:|:|.:|:..|:|.|||.:|||:.:|:.||.||...|..|..|.:|.|:||.||::|..||.
  Fly   365 TLQTKLRLSNRPAYLPTEGKTVSDISNSWKGLELAEKAFEEWLLAETMRLERLEHLAQKFKHKAD 429

Mouse   433 MRETWL-SENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDI 496
            ..|.|. .:.:.|.|||.....|..::|..|||||.|:|:||:::||:.:.|:|:||....|||.
  Fly   430 AHEDWTRGKEEMLQSQDFRQCKLNELKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDC 494

Mouse   497 KRITARKDNVIRLWEYLLELLRARRQRL-EMNLGLQKIFQEMLYI---------MDWMDEMKVLL 551
            ..:.||...:...|:.|..|.:.||..| |....|:||  ::|::         .:|:|..:   
  Fly   495 VSVNARCQRICDQWDRLGALTQRRRTALDEAERILEKI--DILHLEFAKRAAPFNNWLDGTR--- 554

Mouse   552 LSQDYGKHLLGVEDLLQKHALVEADIAIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHM 616
                        ||      ||:..|....|.::|:..                        ||.
  Fly   555 ------------ED------LVDMFIVHTMEEIQGLIQ------------------------AHD 577

Mouse   617 EFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHR 681
            :|            :|.|.|:.:.:.....:      :||.|.|:........|.:....|:   
  Fly   578 QF------------KATLGEADKEFNLIVNL------VREVESIVKQHQIPGGLENPYTTLT--- 621

Mouse   682 AFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLL 746
              .::|:.:.....|.:.:.:..:|.|                          :||::..| .|.
  Fly   622 --ANDMTRKWSDVRQLVPQRDQTLANE--------------------------LRKQQNNE-MLR 657

Mouse   747 HQFQADADDIDAWMLDILKIVSSNDVGHDEYSTQSLVKKHKDVAEEITNYRPTIDTLHEQASALP 811
            .||...|:.:..|:...:..|::..:|. :.|.:..:.:.|:..:.:..|:|.|:          
  Fly   658 RQFAEKANIVGPWIERQMDAVTAIGMGL-QGSLEDQLHRLKEYEQAVYAYKPNIE---------- 711

Mouse   812 QAHAESPDVKGRLAGIEERCKEMAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQ 876
                                    ||.::. ||:|:::.....::.                   
  Fly   712 ------------------------ELEKIH-QAVQESMIFENRYTN------------------- 732

Mouse   877 IPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHNGHPSEKEIRAQQDKLNTRWSQFR 941
                 ..:|.::..:|.|...:|..      :|::..|::..   ..|.|  .|::||...|.|.
  Fly   733 -----YTMETLRVGWEQLLTSINRN------INEVENQILTR---DSKGI--SQEQLNEFRSSFN 781

Mouse   942 ELVDRKKDALLSALSIQNYHLECNETKSWIREKTK--VIESTQDLGNDLAGVMALQRKLTGMERD 1004
                               |.:.|.|.....|:.|  ::.....:|.|..|.:..||.|..::.:
  Fly   782 -------------------HFDKNRTGRLSPEEFKSCLVSLGYSIGKDRQGDLDFQRILAVVDPN 827

Mouse  1005 ---LVAIEAKLSDLQKEA-------------------------EKLESE-HPDQAQAILSRL 1037
               .|..:|.|..:.:|:                         ::|..| .||||:..:.|:
  Fly   828 NTGYVHFDAFLDFMTRESTDTDTAEQVIDSFRILAADKPYILPDELRRELPPDQAEYCIQRM 889

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sptbn1NP_787030.2 Actin-binding 2..275 126/273 (46%)
SAC6 48..>530 CDD:227401 228/506 (45%)
Spectrin 1. /evidence=ECO:0000255 303..411 51/107 (48%)
Spectrin 2. /evidence=ECO:0000255 423..525 39/103 (38%)
SPEC 530..743 CDD:238103 31/221 (14%)
Spectrin 3. /evidence=ECO:0000255 530..636 18/114 (16%)
Spectrin 4. /evidence=ECO:0000255 639..742 12/102 (12%)
SPEC 642..849 CDD:238103 30/206 (15%)
Spectrin 5. /evidence=ECO:0000255 745..847 16/101 (16%)
Spectrin 6. /evidence=ECO:0000255 850..952 13/101 (13%)
SPEC 851..1061 CDD:238103 35/218 (16%)
Spectrin 7. /evidence=ECO:0000255 957..1060 22/112 (20%)
SPEC 958..1169 CDD:238103 22/111 (20%)
Spectrin 8. /evidence=ECO:0000255 1063..1166
Spectrin 9. /evidence=ECO:0000255 1170..1259
SPEC 1171..1380 CDD:238103
Spectrin 10. /evidence=ECO:0000255 1276..1376
SPEC 1381..1592 CDD:238103
Spectrin 11. /evidence=ECO:0000255 1381..1482
Spectrin 12. /evidence=ECO:0000255 1486..1590
Interaction with ANK2. /evidence=ECO:0000250 1563..2093
SPEC 1593..1805 CDD:238103
SPEC 1806..2027 CDD:238103
Spectrin 2017..>2075 CDD:334073
Spectrin 17. /evidence=ECO:0000255 2018..2097
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2089..2193
Mediates interaction with CAMSAP1. /evidence=ECO:0000250 2148..2176
PH_beta_spectrin 2199..2304 CDD:269975
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2308..2363
ActnNP_001259165.1 CH_ACTN_rpt1 31..135 CDD:409063 54/115 (47%)
CH_ACTN_rpt2 139..252 CDD:409065 66/118 (56%)
SPEC 302..525 CDD:238103 96/222 (43%)
SPEC 420..647 CDD:238103 69/322 (21%)
SPEC 538..760 CDD:238103 50/382 (13%)
EFh 775..842 CDD:238008 16/85 (19%)
EFhand_Ca_insen 847..913 CDD:400872 7/43 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D543832at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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