DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sptb and Dys

DIOPT Version :9

Sequence 1:NP_038703.3 Gene:Sptb / 20741 MGIID:98387 Length:2329 Species:Mus musculus
Sequence 2:NP_001036722.1 Gene:Dys / 42327 FlyBaseID:FBgn0260003 Length:3598 Species:Drosophila melanogaster


Alignment Length:2441 Identity:514/2441 - (21%)
Similarity:906/2441 - (37%) Gaps:576/2441 - (23%)


- Green bases have known domain annotations that are detailed below.


Mouse    48 LADEREVVQKKTFTKWVNSHLARVSCR-ISDLYKDLRDGRMLIKLLEVLSGEMLPRPTKGKMRIH 111
            |.|||:.:||||||||:||||....|. :.||:.|||||..|:.||..|:...| :|.||:||:|
  Fly     6 LIDERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNL-KPEKGRMRVH 69

Mouse   112 CLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAK 176
            .:.|::|.:..:::..|.|.|:.|.|||.||.:|.|||||.|.|.|..|.:|    :...:...:
  Fly    70 HINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLV----KSHSSNGVE 130

Mouse   177 DALLLWCQMKTAGYPH-VNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFDV 240
            .:||.|.:..|.  || :.:.:|:|||.||.||..::..|..:| :.......:|...|..|||:
  Fly   131 KSLLAWARQYTE--PHGLQLNDFSSSWSDGRAFLMILDAHVEEL-NLQAALQQHALKRLHLAFDL 192

Mouse   241 AERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIETEKMIE 305
            |.|...|..|||.|||.|..||.|||..||:..||....|:....|.:          :.|...:
  Fly   193 AHRHFKIEKLLDAEDVHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQE----------QDEGQDQ 247

Mouse   306 KYSGLASDLLTWIEQTISVLNSRKFANSLSGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQ 370
            ....:....:|.:::.           .|...|..|..:    |.:.....:::.:.|:...:::
  Fly   248 DPGRVPCTSITDLDEV-----------PLDNDQTSLGLY----TSDSAGSMEQRSSGELKTHSMR 297

Mouse   371 SRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYQREL-ALRSELIRQEKL--EQLARRFDRKAA 432
            ....|.|                   .|:|.:.||..| |:.:.|:..|:|  :.|....|.:.|
  Fly   298 PLSTATN-------------------ASVEISGYQSALEAVLTLLLEDEQLLSQNLPDPQDFQTA 343

Mouse   433 MRETWLNENQRLVTQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVKALEDLAQELEKENYHDQK 497
                      :|...:|..:.|...|..:...||:|..:....|..||...|:|| ::.....|.
  Fly   344 ----------KLQFHENESFMLKLTEHQEYVGEALEEGSNLINESQKAGAGLSQE-DQNEVRQQM 397

Mouse   498 RIIARKDNILRLWS------YLQELLRSRRQRLEATLALQKLFQDMLHSIDWMDEIKAHILSAEF 556
            .::..:...|||.:      .|..|...::|:||   .|::....:...|..|.:|...:..|| 
  Fly   398 VLLNERWETLRLRALDVQAKILMRLAEFQKQKLE---QLRQFLTSVEDRISHMSDIGPTLEEAE- 458

Mouse   557 GKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLQFAEGKGYQPCDPQVIQDRVSHLEQCFSE 621
             |.|||.:.|       :||::.|.:.|.::::..:...:..|    :...::||:|.|.:.:|.
  Fly   459 -KQLLEAQKL-------KADLSEQQELVDSLSSMVVIVNDTSG----NFNDLEDRLSALGERWSH 511

Mouse   622 LSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKE-----------QIYSSLDY-GKDLTSVLI 674
            :...:..||.:|:|.|.:.:  | :|..|..:|..|           |..:.|:| .|||   |.
  Fly   512 VVKWSDLRKEKLQQYKCISR--W-LDAREQDLKLMESRDVTDVGGITQRINELNYCAKDL---LE 570

Mouse   675 LQRKHKAFEDELRGLDAHLKQIFQEADDMVAQKQFGHPQIETRVKEVSAQWDHLKELAAFRKKDL 739
            |||    :..:||.:.|   ...|:.||.       ..::..:::....:.|.||::...:...:
  Fly   571 LQR----YLIDLRQMVA---ATLQDGDDK-------GERVLIQLESYEDRLDALKQIVEVQTVRI 621

Mouse   740 Q-DAENFFQFQGDADDLK-----AWLQDAHRLLSGEDVGQDEGATRALGKKHKEF-----LEELE 793
            : ...||.:.:...||.:     .|:.....:..|||..|::.....|..|.::.     ...||
  Fly   622 ETKGFNFGRDRASYDDSRVVRPEGWVDYQMIIRFGEDDSQEDDDEHDLASKKRKLRNADNFNALE 686

Mouse   794 ESRGVMEHLEHQAQGFPEEFRDSPDVTNRLQALRKLYQQVLTQAEL----------RGHKLQEAL 848
            ..  :|||.     |:.:|      |..:||.|::  |.:..|.||          |...|.|..
  Fly   687 NH--IMEHF-----GYVQE------VEQKLQQLQR--QSLRQQCELLKELQAENSRRCGTLPELK 736

Mouse   849 DLYTVFGESDACELWMTEKGKWLDQMDIPNTLEDLEVVQHRFDILDQEMKTLMAQ------IDGV 907
            .||.|      |||....:...|::..|....:....:..:......|..||:|:      :.|.
  Fly   737 KLYEV------CELEDPSRNLLLEETHIKQLEQRYANLSQKLSSQQSESHTLLAKEKYYNSLTGF 795

Mouse   908 NLAANNLVES-----GHPRSGEVKQYQDRLNKRWQAFQAVVSEQREAVDSALRVNNYCVDCEETS 967
            .|.   |.:|     .|..|....:.:.||:.    .:::.||..||..:...:::..::     
  Fly   796 KLV---LADSRDWYKQHAGSASGNELEQRLSH----MESLASEISEAKTATEELDDNLIE----- 848

Mouse   968 KWIMDKTKVVESTKDLGQDLAGVIAIQRKLSGLERDVLAIRDRVSALERESQYL--MESHPEQKE 1030
             |..|.....:|..|:.|.|..:|. ||....|.|.:..|:|.|:.:..:...:  :|...||:.
  Fly   849 -WKQDFGLFYDSWHDMKQALQALIQ-QRGGESLSRQLKQIQDFVTKVSNQKVRVSNLEVMQEQQH 911

Mouse  1031 DIGQRQADVEKL---WKGLQDALQGQELSLGEASKLQAFLQDLDDFKAWLSMAQKAVASEDMPES 1092
            .:.|...::|.|   :..:...|.|:||.                 .||          ..:||.
  Fly   912 FLNQLLDEMESLRLTYDNIPKHLIGEELQ-----------------TAW----------NRLPEQ 949

Mouse  1093 LPEAEQLLQQHAAIKEEIDAHRDDYHRVKASGEKVIEGQTDPDYQLLGQRLEGLDTDWDALRRMW 1157
            |  .|::::|..|| |.::....:|:.:.|......:.:.:.......|.|..|:.|..:.|   
  Fly   950 L--NERVIKQTTAI-ENLNHFAAEYNAIIAMLRSAADSKLNGSDGASSQDLRKLEIDVISAR--- 1008

Mouse  1158 ESRGNTLTQCLGFQEF--------QKDAKQAEAILSNQEY---TLAHLEPPDSLAAAEAGI---- 1207
                       .|.|.        ||::.|::....|..|   ...|.|..:.....::.|    
  Fly  1009 -----------NFSEILIKEAEPAQKESLQSQIRALNTLYDQVEQVHREKKEQQTVLQSHIDLIQ 1062

Mouse  1208 ---RKFEDFLVSMENNRDKI-LSPVDSGNKLVAEGNLY--------------------SNKIMEK 1248
               ::.:.:|..:|:|..|. :|.:.:.|:|....:.:                    ..:::.:
  Fly  1063 LRLKETDQWLTDLESNTPKSGISDIVNSNELFQSKSRFQTLKETCERETTQFRDLNERGGELLLQ 1127

Mouse  1249 VQLIEDRHKKN------------NEKAQEATVL------LKDNL-----ELQNFLQNCKELTLWI 1290
            :..::|:.:::            |.:..|.|.|      |.:::     |.:.|:.:.......:
  Fly  1128 MDELQDQDRESRYGSLAKQFTRINARWTEVTELVYAKTALLEHISTQLGEFKKFMVSETGYLDKL 1192

Mouse  1291 NDKLLTSPDVSYD------EARNLHNKWMKHQAFMAELASHQGWLENIDAEGRQLMAEKPQFKDV 1349
            .:|:..:|:.:.|      |..:|.|....|.         :.||:.|...|.:|: :.....|.
  Fly  1193 ENKIRNTPENAADAEEIMEELDDLENVLRSHS---------EEWLDKIQEIGNELI-DNEFMADS 1247

Mouse  1350 VSERLEALHKLWEELQSTAKAKAE----QLSAARSSDLRLQTHADLNKWIGAMEDQLRSDDLGKD 1410
            :...::...:.|.:||..||.:.|    ::|.|..|:   :......||:..::|.| ||.|..|
  Fly  1248 IRRDIDETVQRWTQLQQQAKKRTELLEQKVSEAEQSE---KCIVQFEKWLTRVDDIL-SDHLDND 1308

Mouse  1411 LTTVNRMLAKLKRVEEQVNLRK--EELEELFADAPSLGAEAGDTDMSIEKRFLDLLEPLGRRKKQ 1473
            :|.|::.....:...|.|...|  :|:.||. |..:...:.|..:.        |.|.|...:.:
  Fly  1309 VTIVDQPEEFQRLAHEFVANEKNFKEISELI-DEHTRNGKVGAANR--------LQEQLNLMEVR 1364

Mouse  1474 LELSKAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHAPRVEDVL 1538
            .:..:|||.....::..   .|.||..|.     |:|:.|:               .:..|.||.
  Fly  1365 FKYCQAKLSKCTAIQHS---YESRLNRAY-----TDLRNVE---------------RSTEVVDVA 1406

Mouse  1539 RRGQELVKAAEIDCQDIEERLGHLQSSWDTLREAAAGRLQRLRDAHEAQQYYLDAGEAEAWISEQ 1603
            ..|...|:.....|..|...|..::|                              |.|:.|.  
  Fly  1407 SAGPNTVQTQYQKCLQIYRTLSEIKS------------------------------EIESTIK-- 1439

Mouse  1604 ELYVFSDEPPKDEEGAIVMLKRHLRQQRTVEE-YGRNIKQLAGRAQSLLSAGHPEGEQIIRLQGQ 1667
                                    ..:|..|: |.::.|||:.|..:|....:..||.:.:.:..
  Fly  1440 ------------------------TGRRVCEDRYTKSPKQLSQRIDALKHLYNTLGENVTQSKAT 1480

Mouse  1668 VDKQYAGLKDMAEERRRRLENMYHLFQLKREADDLEQWITEKEMVASSQEMGQDFDHVTMLRDKF 1732
            :::... |....||.....:|:...|:..:|..|....:.|.|            |.:....|.:
  Fly  1481 LERLLT-LARQLEECFDSADNLIRRFESPQEVHDRNSILLEFE------------DVLRRCEDHY 1532

Mouse  1733 RDFAR--------ETGAIGQERVDNVNTIIERLIDAGHSEAATIAEWKDGLNDMWADLLELIDTR 1789
            .::.:        ||    ::|:|.:.....:|         |.|:....|.:|...|..|.:..
  Fly  1533 NEYNKSCDQSCMVET----RQRIDGLKATYHKL---------TSADIIKRLTEMKTTLQNLDNIS 1584

Mouse  1790 MQLL-AASYDLHRYFYTGT--------EILGL-IDEKHRELPEDVGLDASTAESFHRVHTAFERE 1844
            ::.| |..:||........        :::.: :|.......|...|.|....|.....|    |
  Fly  1585 LETLRAMEHDLKEINVPSNPEIEKLQQQVIAIVVDVLKTRFNEATTLAARNTSSPDNDDT----E 1645

Mouse  1845 LHLLGVQVQQFQDVATRLQTAYAGEKADAIQSKEQEV----------SAAWQALLDACAGRRAQL 1899
            :.::...|:|     .|.:|..:||...:..:...|.          :...|.:.|....:..:|
  Fly  1646 IVVVSDTVRQ-----RRARTPQSGESPSSAHTSSSESPTKGVENSPGAVGDQVMPDLLPPQTFRL 1705

Mouse  1900 VDTADKFRFFSMVRDLLSWMESIIRQIETQERP-------RDVSS-----VELLLKYHQGIKAEI 1952
               |:....||.:        |:..|..|...|       |...|     ||:.:|..|..|..:
  Fly  1706 ---AESSTLFSQI--------SLNPQKVTNTPPPKPAKTKRKAPSSPAQVVEIRVKNIQNDKMSV 1759

Mouse  1953 NTRAKNFSTCLELGE-----SLLQRQHQASDEIREKLQQV-------ISRRQEMNDKWEARSDRL 2005
                :|.....:.||     ::|:.......|..|.:|.|       .|.|.:...|...||...
  Fly  1760 ----QNIDLEPQQGEIVDTVNILESVEPFVPEYVETVQIVDLSEDSDSSVRVDSQGKEMRRSKSK 1820

Mouse  2006 HMLLEVCQFSRDASVAEAWLIAQEPYLASRDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEK 2070
            |.|.|                ...|.::..|    .||.|   :..:....|..:.:..|..:||
  Fly  1821 HSLNE----------------TPLPKVSDND----EDSAE---QEEDLLRPSAENTSTPFLRVEK 1862

Mouse  2071 PTTL--ELKERQTPERPTEEPGPQEEEGETAGEAPQVHHAATERTSPGEERGPWPQ-DLQPPPLP 2132
            ....  |.::|...||...... :|||.:|. :.|:    |.:.:.|...|...|: |...|..|
  Fly  1863 RRISFDEKRKRVANERDILRDS-EEEEPKTP-DTPR----AAQVSKPKRWRQLQPEMDALEPESP 1921

Mouse  2133 GH---HKDEQEKSVGDERPATEPLFKVLDTPLSEGDEPTTLPAQRDLGHTVQMEGYLGRKHDLEG 2194
            |.   :..::|.....|             ||...|:........::..|:..:....|   :..
  Fly  1922 GRDSFYSPDKESGFDAE-------------PLVFSDDEDIPRFSLEMTSTIDSDSDTSR---IMT 1970

Mouse  2195 PNKKASNRSWNNLYCVLRNSQLTFYKDAKNLALGVPYHGEEPLALRHAICEIAVNYKKKKHVFKL 2259
            |:.|..|...:.:.     ..|:...|..|:.|..|...|:|..|...:.|.  :.:.|:.::||
  Fly  1971 PSTKNPNPFLSKVL-----ESLSSPVDDSNVTLKSPISEEQPQNLDDRVREF--DKQAKQMIYKL 2028

Mouse  2260 RLSNGSEWLFHGKDEEEM-LMWLQSMSTAINESQSI 2294
            :|:.......|..:.|:: |:.....:|.|::..|:
  Fly  2029 KLTKAKIEQCHESEAEDLRLLIAPDAATLISQGDSL 2064

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SptbNP_038703.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30
Actin-binding 2..275 95/228 (42%)
CH 55..158 CDD:237981 50/103 (49%)
CH 177..273 CDD:214479 38/96 (40%)
Spectrin 302..411 CDD:278843 14/109 (13%)
Spectrin 1. /evidence=ECO:0000255 303..411 14/108 (13%)
Spectrin 422..526 CDD:278843 24/109 (22%)
Spectrin 3. /evidence=ECO:0000255 529..635 24/105 (23%)
SPEC 530..742 CDD:238103 50/224 (22%)
Spectrin 4. /evidence=ECO:0000255 638..741 24/115 (21%)
SPEC 641..848 CDD:238103 53/239 (22%)
Spectrin 5. /evidence=ECO:0000255 744..846 28/121 (23%)
SPEC 745..954 CDD:238103 52/239 (22%)
Spectrin 6. /evidence=ECO:0000255 853..950 21/107 (20%)
Spectrin 7. /evidence=ECO:0000255 958..1058 24/104 (23%)
SPEC 962..1168 CDD:238103 41/210 (20%)
Spectrin 8. /evidence=ECO:0000255 1062..1165 17/102 (17%)
SPEC 1170..1379 CDD:238103 45/280 (16%)
Spectrin 9. /evidence=ECO:0000255 1170..1258 18/126 (14%)
Spectrin 10. /evidence=ECO:0000255 1275..1376 21/110 (19%)
SPEC 1385..1475 CDD:197544 21/91 (23%)
Spectrin 11. /evidence=ECO:0000255 1389..1463 18/75 (24%)
Spectrin 12. /evidence=ECO:0000255 1481..1582 17/100 (17%)
SPEC 1485..1690 CDD:238103 33/205 (16%)
Spectrin 13. /evidence=ECO:0000255 1584..1688 16/104 (15%)
SPEC 1691..1901 CDD:238103 39/237 (16%)
SPEC 1798..2005 CDD:238103 46/249 (18%)
Spectrin 15. /evidence=ECO:0000255 1798..1899 18/119 (15%)
Spectrin 16. /evidence=ECO:0000255 1906..2006 26/123 (21%)
Spectrin 17. /evidence=ECO:0000255 2013..2073 9/59 (15%)
Spectrin 2013..>2070 CDD:278843 7/56 (13%)
PH 2180..2288 CDD:278594 21/108 (19%)
PH_beta_spectrin 2182..2287 CDD:269975 20/105 (19%)
DysNP_001036722.1 CH 13..111 CDD:278723 48/98 (49%)
CH 129..225 CDD:278723 38/98 (39%)
SPEC 312..525 CDD:238103 56/239 (23%)
SbcC <325..957 CDD:223496 160/742 (22%)
Smc <816..1591 CDD:224117 170/957 (18%)
SPEC 1174..1365 CDD:238103 45/213 (21%)
SPEC 1289..1485 CDD:295325 53/284 (19%)
SPEC 2369..2576 CDD:238103
SPEC 2477..2714 CDD:238103
WW 2852..2882 CDD:238122
EF-hand_2 2883..2997 CDD:286194
EF-hand_3 3001..3100 CDD:286195
ZZ_dystrophin 3110..3158 CDD:239074
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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