DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERCC6 and RAD26

DIOPT Version :9

Sequence 1:	NP_000115.1	Gene:	ERCC6 / 2074	HGNCID:	3438	Length:	1493	Species:	Homo sapiens
Sequence 2:	NP_012569.1	Gene:	RAD26 / 853492	SGDID:	S000003796	Length:	1085	Species:	Saccharomyces cerevisiae

Alignment Length:	1469	Identity:	469/1469 - (31%)
Similarity:	653/1469 - (44%)	Gaps:	475/1469 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    92 LQGLGVDVYDQDVLEQGVLQQVDNAIHEASRASQLVDVEKEYRSVLDDLTSCTTSLRQINKIIEQ 156
            |:.|||:|..|..||:.:...|.|..:..|...:...:|:          |.|...|.:||
Yeast    18 LKDLGVNVLSQSSLEEKIANDVTNFSNLQSLQQEETRLER----------SKTALQRYVNK---- 68

Human   157 LSPQAATSRDINRKLDSVKR--QKYNKEQQLKKITAKQKHLQAILGGAEVKIELDHASLEEDAEP 219
                   ...:.|||::..|  .|.|...|:|.:  :...::.:|...: .|:.....|:|..:.
Yeast    69 -------KNHLTRKLNNTTRISVKQNLRDQIKNL--QSDDIERVLKDID-DIQSRIKELKEQVDQ 123

Human   220 GPSSLGSM--LMPVQETAWEELIRTGQMTPFGTQIPQKQEKKPRKIMLNEASGFEKYLADQAKLS 282
            |..:.||.  |....||..|.|||||::|.||                 ..:||.   .|.|...
Yeast   124 GAENKGSKEGLQRPGETEKEFLIRTGKITAFG-----------------HKAGFS---LDTANRE 168

Human   283 FERKKQGCNKRAARKAPAPVTPPAPVQNKNKPNKKARVLSKKEERLKKHIKKLQKRALQFQGKVG 347
            :.:..:                                  :|:|..:...:::.:....
Yeast   169 YAKNDE----------------------------------QKDEDFEMATEQMVENLTD------ 193

Human   348 LPKARRPWESDMRPEAEGDSEGEESEYFPTEEEEEEEDDEVEGAEADLSGDGTDYELKPLPKGGK 412
                    |.|...:.:....|:|||    ::||||.||::
Yeast   194 --------EDDNLSDQDYQMSGKESE----DDEEEENDDKI------------------------ 222

Human   413 RQKKVPVQEIDDDFFPSSGEEAEAASVGEGGGGGRKVGRYRDDGDEDYYKQRLRRWNKLRLQDKE 477
                  ::|::|..|  .|:..||                :|||||.||::||::|.|.|....:
Yeast   223 ------LKELEDLRF--RGQPGEA----------------KDDGDELYYQERLKKWVKQRSCGSQ 263

Human   478 KRLKLED----DSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRWLWELHCQQAGGILGDEMGLGK 538
            :...|.:    .....||:.:..||:||.::..||.||:|.|:||:||:.|..|||:||||||||
Yeast   264 RSSDLPEWRRPHPNIPDAKLNSQFKIPGEIYSLLFNYQKTCVQWLYELYQQNCGGIIGDEMGLGK 328

Human   539 TIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHTWWPPFRVAILHETGS- 602
            |||:|||:|.|.:|.:.|          ||.:||||.|||.||..||..||||.|..|||..||
Yeast   329 TIQVIAFIAALHHSGLLT----------GPVLIVCPATVMKQWCNEFQHWWPPLRTVILHSMGSG 383

Human   603 ------------------------------------------YTHKKEKLIRDVAHCHGILITSY 625
                                                      .::..:|||..|.....||||:|
Yeast   384 MASDQKFKMDENDLENLIMNSKPSDFSYEDWKNSTRTKKALESSYHLDKLIDKVVTDGHILITTY 448

Human   626 SYIRLMQDDISRYDWHYVILDEGHKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNLRELWSLFD 690
            ..:|:..|.:.:..|.|.:||||||||||::.::|.||:.:|.:||||||:|:||||.|||||||
Yeast   449 VGLRIHSDKLLKVKWQYAVLDEGHKIRNPDSEISLTCKKLKTHNRIILSGTPIQNNLTELWSLFD 513

Human   691 FIFPGKLGTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLS 755
            |||||||||||||.:||.:||.:|||:||:.:||:|.||||..|||.|:||||||:|:||  :..
Yeast   514 FIFPGKLGTLPVFQQQFVIPINIGGYANATNIQVQTGYKCAVALRDLISPYLLRRVKADV--AKD 576

Human   756 LPDKNEQVLFCRLTDEQHKVYQNFVDSKEVYRILNGEMQIFSGLIALRKICNHPDLFSGGPKNLK 820
            ||.|.|.||||:||..|...|..|:.|.::.:|.||:..:..|:..||||||||||.....|  :
Yeast   577 LPQKKEMVLFCKLTKYQRSKYLEFLHSSDLNQIQNGKRNVLFGIDILRKICNHPDLLDRDTK--R 639

Human   821 GLPDDELEEDQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLDILEVFLRAQ-----KY 880
            ..||       :|..||||||.||:.||.:|||||.:.|||:||||||||||.|:..:     ..
Yeast   640 HNPD-------YGDPKRSGKMQVVKQLLLLWHKQGYKALLFTQSRQMLDILEEFISTKDPDLSHL 697

Human   881 TYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVVIYDPDWNPSTDTQAR 945
            .||:|||||.|..||.|:.|:|.: |..||||||||||||||||||||::|:|||||||||.|||
Yeast   698 NYLRMDGTTNIKGRQSLVDRFNNE-SFDVFLLTTRVGGLGVNLTGANRIIIFDPDWNPSTDMQAR 761

Human   946 ERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQRRFFKSNDLYELFTLTSP 1010
            |||||||||::|::|||:..|:||||||||||||||||||:|.||||:||||.::|::||:|
Yeast   762 ERAWRIGQKREVSIYRLMVGGSIEEKIYHRQIFKQFLTNRILTDPKQKRFFKIHELHDLFSL--- 823

Human  1011 DASQSTETSAIFAGTGSDVQTPKCHLKRRIQPAFGADHDVPKRKKFPASNISVNDATSSEEKSEA 1075
                                              |.:                 :..|:||.:|
Yeast   824 ----------------------------------GGE-----------------NGYSTEELNE- 836

Human  1076 KGAEVNAVTSNRSDPLKDDPHMSSNVTSNDRLGEETNAVSGPEELSVISGNGECSNSSGTGKTSM 1140
               ||...|.|    ||:    |.:..|:|.           |:|         .|.||..|
Yeast   837 ---EVQKHTEN----LKN----SKSEESDDF-----------EQL---------VNLSGVSK--- 867

Human  1141 PSGDESIDEKLGLSYKRERPSQAQTEAFWENKQMENNFYKHKSKTKHHSVAEEETLEKHLRPKQK 1205
                                                                   ||.....|:|
Yeast   868 -------------------------------------------------------LESFYNGKEK 877

Human  1206 PKNSKHCRDAKFEGTRIPHLVKKRRYQKQDSENKSEAKEQSNDDYVLEKLFKKSVGVHSVMKHDA 1270
            .:|||                                   :.||.::|.|......:.:||.||:
Yeast   878 KENSK-----------------------------------TEDDRLIEGLLGGESNLETVMSHDS 907

Human  1271 IMD---GASPDYVLVEAEANRVAQDALKALRLSRQRCLGAVS-GVPTWTGHRGISGAPAGKKSRF 1331
            :::   |:|...::.: ||:|||.:|:.|||.||::...... |.|||||             ||
Yeast   908 VVNSHAGSSSSNIITK-EASRVAIEAVNALRKSRKKITKQYEIGTPTWTG-------------RF 958

Human  1332 GKKRNSNFSVQHPSSTSPTEKCQDGIMKKEGKDNVPEHFSGRAEDADSSSGPLASSSLLAKMRAR 1396
            ||.                     |.::|  :|.:....:|.|    :..|.:..|...|...||
Yeast   959 GKA---------------------GKIRK--RDPLKNKLTGSA----AILGNITKSQKEASKEAR 996

Human  1397 NH-------LILPERLESESGHLQEASALLPTTEHDDLLVEMRNFIAFQAHTDGQASTREILQEF 1454
            ..       ....:.:.|.:..|:...|.|.         :..||.         :|:..||...
Yeast   997 QENYDDGITFARSKEINSNTKTLENIRAYLQ---------KQNNFF---------SSSVSILNSI 1043

Human  1455 ESKLSASQSCV-FRELLRNLCTFHRTSGGEGIWKLKPEY 1492
            ...||..:..: .|.||:.:..|.:...|   |.|..|:
Yeast  1044 GVSLSDKEDVIKVRALLKTIAQFDKERKG---WVLDEEF 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERCC6	NP_000115.1	N-terminal domain, essential for its chromatin remodeling activity. /evidence=ECO:0000269\|PubMed:29203878	1..510		89/425 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..323		0/35 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..453		18/108 (17%)
		SNF2_N	510..812	CDD:278600	167/344 (49%)
		DEXDc	527..677	CDD:238005	77/192 (40%)
		DEAH box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	646..649		2/2 (100%)
		HELICc	830..960	CDD:238034	87/134 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1042..1147		20/104 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1181..1247		7/65 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1318..1384		10/65 (15%)
		Ubiquitin-binding domain (UBD). /evidence=ECO:0000269\|PubMed:20541997	1400..1428		4/27 (15%)
		Winged-helix domain (WHD). /evidence=ECO:0000305\|PubMed:29203878	1429..1493		15/65 (23%)
		Essential for its interaction with RNA polymerase II, transcription-coupled nucleotide excision repair activity, association with chromatin after UV irradiation and for mediating the UV-induced translocation of ERRC8 to the nuclear matrix. /evidence=ECO:0000269\|PubMed:26620705	1446..1493		13/48 (27%)
RAD26	NP_012569.1	HepA	2..824	CDD:223627	382/1008 (38%)
RAD26	NP_012569.1	DEXHc_ERCC6	297..517	CDD:350758	102/229 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C159051453
Domainoid	1	1.000	314	1.000	Domainoid score	I218
eggNOG	1	0.900	-	-		E2759_KOG0387
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	643	1.000	Inparanoid score	I128
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005396
OrthoInspector	1	1.000	-	-		oto145152
orthoMCL	1	0.900	-	-		OOG6_103189
Panther	1	1.100	-	-	LDO	PTHR45629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3828
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.750