DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ERCC6 and RAD26

DIOPT Version :10

Sequence 1:NP_000115.1 Gene:ERCC6 / 2074 HGNCID:3438 Length:1493 Species:Homo sapiens
Sequence 2:NP_012569.1 Gene:RAD26 / 853492 SGDID:S000003796 Length:1085 Species:Saccharomyces cerevisiae


Alignment Length:1469 Identity:469/1469 - (31%)
Similarity:653/1469 - (44%) Gaps:475/1469 - (32%)


- Green bases have known domain annotations that are detailed below.


Human    92 LQGLGVDVYDQDVLEQGVLQQVDNAIHEASRASQLVDVEKEYRSVLDDLTSCTTSLRQINKIIEQ 156
            |:.|||:|..|..||:.:...|.|..:..|...:...:|:          |.|...|.:||    
Yeast    18 LKDLGVNVLSQSSLEEKIANDVTNFSNLQSLQQEETRLER----------SKTALQRYVNK---- 68

Human   157 LSPQAATSRDINRKLDSVKR--QKYNKEQQLKKITAKQKHLQAILGGAEVKIELDHASLEEDAEP 219
                   ...:.|||::..|  .|.|...|:|.:  :...::.:|...: .|:.....|:|..:.
Yeast    69 -------KNHLTRKLNNTTRISVKQNLRDQIKNL--QSDDIERVLKDID-DIQSRIKELKEQVDQ 123

Human   220 GPSSLGSM--LMPVQETAWEELIRTGQMTPFGTQIPQKQEKKPRKIMLNEASGFEKYLADQAKLS 282
            |..:.||.  |....||..|.|||||::|.||                 ..:||.   .|.|...
Yeast   124 GAENKGSKEGLQRPGETEKEFLIRTGKITAFG-----------------HKAGFS---LDTANRE 168

Human   283 FERKKQGCNKRAARKAPAPVTPPAPVQNKNKPNKKARVLSKKEERLKKHIKKLQKRALQFQGKVG 347
            :.:..:                                  :|:|..:...:::.:....      
Yeast   169 YAKNDE----------------------------------QKDEDFEMATEQMVENLTD------ 193

Human   348 LPKARRPWESDMRPEAEGDSEGEESEYFPTEEEEEEEDDEVEGAEADLSGDGTDYELKPLPKGGK 412
                    |.|...:.:....|:|||    ::||||.||::                        
Yeast   194 --------EDDNLSDQDYQMSGKESE----DDEEEENDDKI------------------------ 222

Human   413 RQKKVPVQEIDDDFFPSSGEEAEAASVGEGGGGGRKVGRYRDDGDEDYYKQRLRRWNKLRLQDKE 477
                  ::|::|..|  .|:..||                :|||||.||::||::|.|.|....:
Yeast   223 ------LKELEDLRF--RGQPGEA----------------KDDGDELYYQERLKKWVKQRSCGSQ 263

Human   478 KRLKLED----DSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRWLWELHCQQAGGILGDEMGLGK 538
            :...|.:    .....||:.:..||:||.::..||.||:|.|:||:||:.|..|||:||||||||
Yeast   264 RSSDLPEWRRPHPNIPDAKLNSQFKIPGEIYSLLFNYQKTCVQWLYELYQQNCGGIIGDEMGLGK 328

Human   539 TIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHTWWPPFRVAILHETGS- 602
            |||:|||:|.|.:|.:.|          ||.:||||.|||.||..||..||||.|..|||..|| 
Yeast   329 TIQVIAFIAALHHSGLLT----------GPVLIVCPATVMKQWCNEFQHWWPPLRTVILHSMGSG 383

Human   603 ------------------------------------------YTHKKEKLIRDVAHCHGILITSY 625
                                                      .::..:|||..|.....||||:|
Yeast   384 MASDQKFKMDENDLENLIMNSKPSDFSYEDWKNSTRTKKALESSYHLDKLIDKVVTDGHILITTY 448

Human   626 SYIRLMQDDISRYDWHYVILDEGHKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNLRELWSLFD 690
            ..:|:..|.:.:..|.|.:||||||||||::.::|.||:.:|.:||||||:|:||||.|||||||
Yeast   449 VGLRIHSDKLLKVKWQYAVLDEGHKIRNPDSEISLTCKKLKTHNRIILSGTPIQNNLTELWSLFD 513

Human   691 FIFPGKLGTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLS 755
            |||||||||||||.:||.:||.:|||:||:.:||:|.||||..|||.|:||||||:|:||  :..
Yeast   514 FIFPGKLGTLPVFQQQFVIPINIGGYANATNIQVQTGYKCAVALRDLISPYLLRRVKADV--AKD 576

Human   756 LPDKNEQVLFCRLTDEQHKVYQNFVDSKEVYRILNGEMQIFSGLIALRKICNHPDLFSGGPKNLK 820
            ||.|.|.||||:||..|...|..|:.|.::.:|.||:..:..|:..||||||||||.....|  :
Yeast   577 LPQKKEMVLFCKLTKYQRSKYLEFLHSSDLNQIQNGKRNVLFGIDILRKICNHPDLLDRDTK--R 639

Human   821 GLPDDELEEDQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLDILEVFLRAQ-----KY 880
            ..||       :|..||||||.||:.||.:|||||.:.|||:||||||||||.|:..:     ..
Yeast   640 HNPD-------YGDPKRSGKMQVVKQLLLLWHKQGYKALLFTQSRQMLDILEEFISTKDPDLSHL 697

Human   881 TYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVVIYDPDWNPSTDTQAR 945
            .||:|||||.|..||.|:.|:|.: |..||||||||||||||||||||::|:|||||||||.|||
Yeast   698 NYLRMDGTTNIKGRQSLVDRFNNE-SFDVFLLTTRVGGLGVNLTGANRIIIFDPDWNPSTDMQAR 761

Human   946 ERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQRRFFKSNDLYELFTLTSP 1010
            |||||||||::|::|||:..|:||||||||||||||||||:|.||||:||||.::|::||:|   
Yeast   762 ERAWRIGQKREVSIYRLMVGGSIEEKIYHRQIFKQFLTNRILTDPKQKRFFKIHELHDLFSL--- 823

Human  1011 DASQSTETSAIFAGTGSDVQTPKCHLKRRIQPAFGADHDVPKRKKFPASNISVNDATSSEEKSEA 1075
                                              |.:                 :..|:||.:| 
Yeast   824 ----------------------------------GGE-----------------NGYSTEELNE- 836

Human  1076 KGAEVNAVTSNRSDPLKDDPHMSSNVTSNDRLGEETNAVSGPEELSVISGNGECSNSSGTGKTSM 1140
               ||...|.|    ||:    |.:..|:|.           |:|         .|.||..|   
Yeast   837 ---EVQKHTEN----LKN----SKSEESDDF-----------EQL---------VNLSGVSK--- 867

Human  1141 PSGDESIDEKLGLSYKRERPSQAQTEAFWENKQMENNFYKHKSKTKHHSVAEEETLEKHLRPKQK 1205
                                                                   ||.....|:|
Yeast   868 -------------------------------------------------------LESFYNGKEK 877

Human  1206 PKNSKHCRDAKFEGTRIPHLVKKRRYQKQDSENKSEAKEQSNDDYVLEKLFKKSVGVHSVMKHDA 1270
            .:|||                                   :.||.::|.|......:.:||.||:
Yeast   878 KENSK-----------------------------------TEDDRLIEGLLGGESNLETVMSHDS 907

Human  1271 IMD---GASPDYVLVEAEANRVAQDALKALRLSRQRCLGAVS-GVPTWTGHRGISGAPAGKKSRF 1331
            :::   |:|...::.: ||:|||.:|:.|||.||::...... |.|||||             ||
Yeast   908 VVNSHAGSSSSNIITK-EASRVAIEAVNALRKSRKKITKQYEIGTPTWTG-------------RF 958

Human  1332 GKKRNSNFSVQHPSSTSPTEKCQDGIMKKEGKDNVPEHFSGRAEDADSSSGPLASSSLLAKMRAR 1396
            ||.                     |.::|  :|.:....:|.|    :..|.:..|...|...||
Yeast   959 GKA---------------------GKIRK--RDPLKNKLTGSA----AILGNITKSQKEASKEAR 996

Human  1397 NH-------LILPERLESESGHLQEASALLPTTEHDDLLVEMRNFIAFQAHTDGQASTREILQEF 1454
            ..       ....:.:.|.:..|:...|.|.         :..||.         :|:..||...
Yeast   997 QENYDDGITFARSKEINSNTKTLENIRAYLQ---------KQNNFF---------SSSVSILNSI 1043

Human  1455 ESKLSASQSCV-FRELLRNLCTFHRTSGGEGIWKLKPEY 1492
            ...||..:..: .|.||:.:..|.:...|   |.|..|:
Yeast  1044 GVSLSDKEDVIKVRALLKTIAQFDKERKG---WVLDEEF 1079

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ERCC6NP_000115.1 N-terminal domain, essential for its chromatin remodeling activity. /evidence=ECO:0000269|PubMed:29203878 1..510 89/425 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..39
cc_ERCC-6_N 83..159 CDD:411064 17/66 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 287..323 0/35 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 344..453 18/108 (17%)
HepA 391..987 CDD:440319 307/647 (47%)
DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541 646..649 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1042..1147 20/104 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1181..1247 7/65 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1318..1384 10/65 (15%)
CSA-interacting motif (CIM). /evidence=ECO:0000269|PubMed:32355176 1386..1398 4/11 (36%)
Ubiquitin-binding domain (UBD). /evidence=ECO:0000269|PubMed:20541997 1400..1428 4/27 (15%)
CSB_WHD 1420..1492 CDD:439329 14/72 (19%)
Winged-helix domain (WHD). /evidence=ECO:0000305|PubMed:29203878 1429..1493 15/65 (23%)
Essential for its interaction with RNA polymerase II, transcription-coupled nucleotide excision repair activity, association with chromatin after UV irradiation and for mediating the UV-induced translocation of ERRC8 to the nuclear matrix. /evidence=ECO:0000269|PubMed:26620705 1446..1493 13/48 (27%)
RAD26NP_012569.1 HepA <222..792 CDD:440319 296/639 (46%)
CSB_WHD 1019..1080 CDD:439329 18/82 (22%)
Blue background indicates that the domain is not in the aligned region.

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