DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ERCC6 and XNP

DIOPT Version :9

Sequence 1:NP_000115.1 Gene:ERCC6 / 2074 HGNCID:3438 Length:1493 Species:Homo sapiens
Sequence 2:NP_651398.1 Gene:XNP / 43080 FlyBaseID:FBgn0039338 Length:1311 Species:Drosophila melanogaster


Alignment Length:1256 Identity:295/1256 - (23%)
Similarity:505/1256 - (40%) Gaps:375/1256 - (29%)


- Green bases have known domain annotations that are detailed below.


Human   117 IHEASRASQLV------DVEKEYRSVLDDLTSCTTSLRQINKIIEQLSPQAATSRDINRKLDSVK 175
            :..:|.:.|.|      |.|||        ..|...:..:.|::  .||:.              
  Fly    68 VSSSSDSDQAVANSSANDEEKE--------PVCKIRIVPLEKLL--ASPKT-------------- 108

Human   176 RQKYNKEQQLKKITAKQKHLQAILGGAEV-----KIELDHASLEE--DAEPGPSSLGSMLMPVQE 233
            :::.::..|.|.:|......:..|.|:::     |....:||:.|  |:|.......|:|:.:  
  Fly   109 KERPSRGSQQKNVTINDSSDEEPLKGSKLVLPARKSRNKNASIIELSDSEEVDEEEESLLVAI-- 171

Human   234 TAWEELIRTGQMTPFGTQIPQKQEKKPRKIMLNEASGFEKYLAD-------------QAKLSFER 285
                .|.:..|.|.     |:|...|..|..:.:....:|....             :..||.||
  Fly   172 ----PLPKEAQQTK-----PEKNSSKASKESIEKRQKAQKEATTSSARAIRSVNGTRRGSLSSER 227

Human   286 KKQGCNKRAARKAPAPVTPPAPVQ----------NKNKPNKKARVLSKKEERLKKHIKKLQKRAL 340
            ..:..:.||.       :||.|.:          .|.||.:|.:.:|...|......||.::|. 
  Fly   228 SSRASSSRAE-------SPPRPKRCVVRLKRVSLPKTKPAQKPKKMSSDSEEAATTSKKSRQRR- 284

Human   341 QFQGKVGLPKARRPWESDMRPEAEGDSEGEESEYFPTEEEEEEEDDEVEGAEADLSGDGTDYELK 405
                              .:.|:|.||:.|.    |..||||||:.:..|.|.: :.:.:|.|:.
  Fly   285 ------------------SKSESEADSDYEA----PAAEEEEEEERKSSGDEEE-AANSSDSEVM 326

Human   406 PLPKGGKRQKKVPVQEIDDDFFPSSGEEAEA------ASVGEGGGGGRKVGRYRDDGDEDYYKQR 464
            |..|  :|:||....:...||.|...::.:.      .|.||..|          |||:|..|.:
  Fly   327 PQRK--RRRKKSESDKGSSDFEPEEKQKKKGRKRIKKTSSGESDG----------DGDDDKQKNK 379

Human   465 LRRWNKL----------------------RLQDKEK---RLKLEDDSEESD---AEFDEGFK--- 498
            .:...|:                      |::|::|   |:.::.:|.|.:   .:|||..|   
  Fly   380 RKHIRKIIKTKDLDLTTKEAAKEEDDRRKRIEDRQKLYNRIFVKSESVEINELVLDFDEESKKAL 444

Human   499 --VPGFLFKKLFKYQQTGVRWLWELHCQQ----------AGGILGDEMGLGKTIQIIAFLAGLSY 551
              |...|.|||..:|..||:::|:. |.:          :|.||...||||||:|::.    ||:
  Fly   445 LQVDKGLLKKLKPHQVAGVKFMWDA-CFETLKESQEKPGSGCILAHCMGLGKTLQVVT----LSH 504

Human   552 SKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHTWWPPF--RVAI-LHETGSYTHKKEKL--I 611
            :.:    .|.|..|:...:|:.|.:.::.|.:|| |.|..|  |..| :::...|..|..::  :
  Fly   505 TLL----VNTRRTGVDRVLIISPLSTVNNWAREF-TSWMKFANRNDIEVYDISRYKDKPTRIFKL 564

Human   612 RDVAHCHGILITSYSYIRLMQDDISR------------------YDWHYVILDEGHKIRNPNAAV 658
            .:..:..|:.|..|...|::.::.::                  .|  .|:.||||.::|...::
  Fly   565 NEWFNEGGVCILGYDMYRILANEKAKGLRKKQREQLMQALVDPGPD--LVVCDEGHLLKNEKTSI 627

Human   659 TLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNASPVQ 723
            :.|..:.||..||:|:|:|:||||||.:.:..|:.|..|||...:|.:|..|||.|.|::::...
  Fly   628 SKAVTRMRTKRRIVLTGTPLQNNLREYYCMIQFVKPNLLGTYKEYMNRFVNPITNGQYTDSTERD 692

Human   724 VKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLPDKNEQVLFCRLTDEQHKVYQNFVDSKEVYR- 787
            ::.....:.:|...:...:.||..|  .::..||.|:|.|::..|::.|.|:|..::.:..... 
  Fly   693 LRLMKHRSHILHKLLEGCIQRRDYS--VLAPYLPPKHEYVVYTTLSELQQKLYGYYMTTHREQSG 755

Human   788 --ILNGEMQIFSGLIALRKICNHP-------------DLFSGGPKNLKGLPDDELEEDQFG---- 833
              ::....::|.....||:|..||             .|.|....:::|...||.:||:..    
  Fly   756 GDVVGKGARLFQDFQDLRRIWTHPMNLRVNSDNVIAKRLLSNDDSDMEGFICDETDEDEAASNSS 820

Human   834 ------------------------------------------------------------YWK-- 836
                                                                        :||  
  Fly   821 DSCETFKSDASMSGLAASSGKVKKRKTRNGNAGGGDSDSDLEMLGGLGGGSSVQKDDPSEWWKPF 885

Human   837 ----------RSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLDILEVFL-----RAQKY------ 880
                      .|.|::::..||:.....|.::|:||||.|.||::|.||     ..:.|      
  Fly   886 VEERELNNVHHSPKLLILLRLLQQCEAIGDKLLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDV 950

Human   881 -----------TYLKMDGTTTIASRQPLITRYNEDTSI--FVFLLTTRVGGLGVNLTGANRVVIY 932
                       .|.::||:.::..|:.:..::|..|::  .:||::||.||||:||..||||||:
  Fly   951 GDFKGCWTSGKDYFRLDGSCSVEQREAMCKQFNNITNLRARLFLISTRAGGLGINLVAANRVVIF 1015

Human   933 DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQRRFFK 997
            |..||||.|||:..|.:|.||.|...:|||:..||:|:|:|.||:.||....||:.:.:..|.:.
  Fly  1016 DVSWNPSHDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQKVYERQVAKQATAKRVIDEQQISRHYN 1080

Human   998 SNDLYELFTLTSPDASQSTETSAIFAGTGSDVQTPKCHLKRRIQPAFGADHDVPKRKKFPASNIS 1062
            ..||.||:   |.:...|||                     |..|.      :||.:.|.     
  Fly  1081 QTDLMELY---SYELKPSTE---------------------REMPI------LPKDRLFA----- 1110

Human  1063 VNDATSSEEKSEAKGAEVNAVTSNRSDPLKDDPHMSSNVTSNDRL-------GEETNAVSGPEEL 1120
              :..:..||...|..|.:::       |:.:.|  .|:|..:|.       .|:|..|...:.:
  Fly  1111 --EILTEHEKLIFKYHEHDSL-------LEQEEH--ENLTEEERKSAWAEYEAEKTRTVQASQYM 1164

Human  1121 SV---ISGN---GECSNSSGT 1135
            |.   ..||   |:..|:||:
  Fly  1165 SYDRNAFGNQVMGQFGNASGS 1185

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ERCC6NP_000115.1 N-terminal domain, essential for its chromatin remodeling activity. /evidence=ECO:0000269|PubMed:29203878 1..510 99/467 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..39
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 287..323 9/45 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 344..453 28/114 (25%)
SNF2_N 510..812 CDD:278600 88/350 (25%)
DEXDc 527..677 CDD:238005 45/172 (26%)
DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541 646..649 2/2 (100%)
HELICc 830..960 CDD:238034 55/229 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1042..1147 23/107 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1181..1247
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1318..1384
Ubiquitin-binding domain (UBD). /evidence=ECO:0000269|PubMed:20541997 1400..1428
Winged-helix domain (WHD). /evidence=ECO:0000305|PubMed:29203878 1429..1493
Essential for its interaction with RNA polymerase II, transcription-coupled nucleotide excision repair activity, association with chromatin after UV irradiation and for mediating the UV-induced translocation of ERRC8 to the nuclear matrix. /evidence=ECO:0000269|PubMed:26620705 1446..1493
XNPNP_651398.1 DTHCT 258..335 CDD:285332 27/102 (26%)
SNF2_N 458..779 CDD:278600 86/334 (26%)
DEXDc 483..646 CDD:238005 45/173 (26%)
Helicase_C 913..1035 CDD:278689 45/121 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.