DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ERCC6 and brm

DIOPT Version :9

Sequence 1:NP_000115.1 Gene:ERCC6 / 2074 HGNCID:3438 Length:1493 Species:Homo sapiens
Sequence 2:NP_001261906.1 Gene:brm / 39744 FlyBaseID:FBgn0000212 Length:1658 Species:Drosophila melanogaster


Alignment Length:1403 Identity:329/1403 - (23%)
Similarity:550/1403 - (39%) Gaps:392/1403 - (27%)


- Green bases have known domain annotations that are detailed below.


Human     1 MPNEGIPHS--------------SQTQEQDCLQSQPVSNNEEMAIKQESGGDGEVEEYLSFRSVG 51
            :||.|.|.|              .|.|.:..|...|..:.    :.|..||...           
  Fly   329 LPNGGKPLSMGPSGGQPLIPSSPMQPQVRGTLPGMPPGSQ----VPQPGGGPQR----------- 378

Human    52 DGLSTSAVGCASAAPRR----------GPALLHIDRHQIQAVEPSAQALELQGLGVDVYDQDVLE 106
               .....|.....|.|          .|..|..:|....|...|.:..|||.|...: .:|:..
  Fly   379 ---QVPPAGMPMPKPNRITTVAKPVGLDPITLLQERENRIAARISLRMQELQRLPATM-SEDLRL 439

Human   107 QGVLQQVDNAIHEASRASQLVDVEKEYRSVLDDLTSCTTSLR-QIN-KIIEQLSPQAATSRDINR 169
            |..::         .||.::::.:::.|......|...|:|. .:| |:.::...|.........
  Fly   440 QAAIE---------LRALRVLNFQRQLRMEFVQCTRRDTTLETALNIKLYKRTKRQGLREARATE 495

Human   170 KLDSVKRQKYNKEQQLKKITAKQKHLQAILGGAEVKIELDHA-SLEEDAEPGPSSLGSM---LMP 230
            ||:  |:||...|::     .:||||:.:   |.|   |.|. .|.|......:.|..|   :|.
  Fly   496 KLE--KQQKLEAERK-----RRQKHLEFL---AAV---LQHGKDLREFHRNNKAQLARMNKAVMN 547

Human   231 VQETAWEELIRTGQMTPFGTQIPQKQE------KKPRKIMLNEASGFEKYLADQAKLSFERKKQG 289
            ....|..|               ||:|      ::.|::|..:..|:.| |.||.|         
  Fly   548 HHANAERE---------------QKKEQERIEKERMRRLMAEDEEGYRK-LIDQKK--------- 587

Human   290 CNKRAA---RKAPAPVTPPAPVQNKNKPNKKARVLSKKEERLKKHIKKLQKRALQFQGK-VGLP- 349
             :||.|   .:....::....:..::|.::    :.||||..|:.|:  .|:.|...|: :|:. 
  Fly   588 -DKRLAFLLSQTDEYISNLTQMVKQHKDDQ----MKKKEEEGKRLIQ--FKKELLMSGEYIGIDE 645

Human   350 ----------------------------KARRPWESDMRP-----EAEGDSEGEESEYFP-TEEE 380
                                        |....| .:|.|     :.|.||.|...::.| .||:
  Fly   646 GSIVADMRVHVVEQCTGKKLTGDDAPMLKHLHRW-LNMHPGWDWIDDEEDSCGSNDDHKPKVEEQ 709

Human   381 EEEEDDEVEGAEADLSGDGTDYELKPLPKGGKRQKKVPVQEIDDDFFPSSGEEAEAASVGEGGGG 445
            ....:|..:.|:|    .|.|.:.|.|         :...:::||                    
  Fly   710 PTATEDATDKAQA----TGNDEDAKDL---------ITKAKVEDD-------------------- 741

Human   446 GRKVGRYRDDGDEDYYKQRLRRWNKLRLQDKEKRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKY 510
                 .||.: ::.||                   .:.....|...| .....|.|    .|.:|
  Fly   742 -----EYRTE-EQTYY-------------------SIAHTIHEKVVE-QASIMVNG----TLKEY 776

Human   511 QQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPT 575
            |..|:.||..|:.....|||.||||||||||.|:.:..|...|          :.:||.:|:.|.
  Fly   777 QIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRK----------KVMGPYLIIVPL 831

Human   576 TVMHQWVKEFHTWWPPFRVAILHETGSYTHKKEKLIRDV--AHCHGILITSYSYIRLMQDDISRY 638
            :.:..||.||..|.|  .|.::...||  .:..:|:::.  |....:|:|:|.|:...:..:::.
  Fly   832 STLPNWVLEFEKWAP--AVGVVSYKGS--PQGRRLLQNQMRATKFNVLLTTYEYVIKDKAVLAKI 892

Human   639 DWHYVILDEGHKIRNPNAAVTLACK-QFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPV 702
            .|.|:|:||||:::|.:..:|.... .:..|:|::|:|:|:||.|.|||:|.:|:.|....:...
  Fly   893 QWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCST 957

Human   703 FMEQFSVPITMGGYSNASPVQVKTAYKCACV--LRDTINPYLLRRMKSDVKMSLSLPDKNEQVLF 765
            |.:.|:.|....|    ..|::........:  |...:.|:||||:|.:|:.  .||||.|.::.
  Fly   958 FEQWFNAPFATTG----EKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEH--QLPDKVEYIIK 1016

Human   766 CRLTDEQHKVYQNFVDSKEVYRIL-----------NGEMQIFSGLIALRKICNHPDLF------- 812
            |.::..|..:|:: :.||.|  :|           .|...:.:.::.|||:||||.:|       
  Fly  1017 CDMSALQRVLYKH-MQSKGV--LLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQHIEEKY 1078

Human   813 ---SGGPKNLKGLPDDELEEDQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLDILEVF 874
               :||...:.| ||         .::.|||..:::.:|........|||||.|..|.:.|:|.:
  Fly  1079 CDHTGGHGVVSG-PD---------LYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDY 1133

Human   875 LRAQKYTYLKMDGTTTIASRQPLITRYN-EDTSIFVFLLTTRVGGLGVNLTGANRVVIYDPDWNP 938
            |..:::.||::||||....|..|:.::| :.:.:|||||:||.||||:||..|:.|||:|.||||
  Fly  1134 LGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNP 1198

Human   939 STDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQRRFFKSNDLYE 1003
            ..|.||::||.||||:.:|.|.||:|..::||:|.....:|..:..:|:    |...|...    
  Fly  1199 HQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVI----QAGMFDQK---- 1255

Human  1004 LFTLTSPDASQSTETSAIFAGTGSDVQTPKCHLKRRIQPAFGADHDVPKRKKFPASNISVNDATS 1068
                                .|||:                        |::| ...|...|...
  Fly  1256 --------------------STGSE------------------------RQQF-LQTILHQDDNE 1275

Human  1069 SEEKSEAKGAE-VNAVTSNRSDPLKDDPHMSSNVTSNDRLGEETNAVSGPEELSVISGNGECSNS 1132
            .||::|....| :|.:.:...:.::....|.:     :|..|:.....|.|.|            
  Fly  1276 EEEENEVPDDEMINMMIARSEEEIEIFKRMDA-----ERKKEDEEIHPGRERL------------ 1323

Human  1133 SGTGKTSMP---SGDESIDEKLGLSYKRE----RPSQAQTEAFWENKQMENNFYKHKSKTKHHSV 1190
              ..::.:|   :.|:...|:....|..:    |.|:.:.|..:.:...|..:.|..........
  Fly  1324 --IDESELPDWLTKDDDEVERFHYQYDEDTILGRGSRQRKEVDYTDSLTEKEWLKAIDDGAEFDE 1386

Human  1191 AEEETLEKHLRPKQKPKNSKHCRDAKFEGTRIPHLVKKRRYQKQDSENKSEAKEQSNDDYVLEKL 1255
            .|||...|..|.|:|.:..:...|:.        ::|:||.|..|..:|.:          :.|:
  Fly  1387 EEEEDDSKRKRRKRKNRKEESDDDSL--------ILKRRRRQNLDKRSKKQ----------MHKI 1433

Human  1256 FKKSVGVHSVMKHDAIMDGAS--------------PDY 1279
                  :.:|:||:  .||.:              |||
  Fly  1434 ------MSAVIKHN--QDGRTLSEPFMKLPSRQRLPDY 1463

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ERCC6NP_000115.1 N-terminal domain, essential for its chromatin remodeling activity. /evidence=ECO:0000269|PubMed:29203878 1..510 110/583 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..39 12/51 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 287..323 4/38 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 344..453 22/144 (15%)
SNF2_N 510..812 CDD:278600 97/317 (31%)
DEXDc 527..677 CDD:238005 48/152 (32%)
DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541 646..649 2/2 (100%)
HELICc 830..960 CDD:238034 55/130 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1042..1147 17/108 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1181..1247 14/65 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1318..1384
Ubiquitin-binding domain (UBD). /evidence=ECO:0000269|PubMed:20541997 1400..1428
Winged-helix domain (WHD). /evidence=ECO:0000305|PubMed:29203878 1429..1493
Essential for its interaction with RNA polymerase II, transcription-coupled nucleotide excision repair activity, association with chromatin after UV irradiation and for mediating the UV-induced translocation of ERRC8 to the nuclear matrix. /evidence=ECO:0000269|PubMed:26620705 1446..1493
brmNP_001261906.1 QLQ 172..202 CDD:214931
Drf_FH1 251..390 CDD:283903 13/78 (17%)
HSA 501..573 CDD:214727 22/97 (23%)
BRK 649..693 CDD:197800 4/44 (9%)
PHA02934 687..>824 CDD:165245 47/209 (22%)
SNF2_N 776..1071 CDD:278600 97/317 (31%)
DEXDc 793..932 CDD:238005 48/152 (32%)
Helicase_C 1097..1212 CDD:278689 51/114 (45%)
SnAC 1304..1375 CDD:291293 14/89 (16%)
Bromo_SNF2L2 1425..1530 CDD:99947 10/57 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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