DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ERCC5 and mus201

DIOPT Version :10

Sequence 1:NP_000114.3 Gene:ERCC5 / 2073 HGNCID:3437 Length:1186 Species:Homo sapiens
Sequence 2:NP_001027230.1 Gene:mus201 / 3772069 FlyBaseID:FBgn0002887 Length:1236 Species:Drosophila melanogaster


Alignment Length:1272 Identity:362/1272 - (28%)
Similarity:587/1272 - (46%) Gaps:277/1272 - (21%)


- Green bases have known domain annotations that are detailed below.


Human     1 MGVQGLWKLLECSGRQVSPEALEGKILAVDISIWLNQALKGVRDRHGNSIENPHLLTLFHRLCKL 65
            |||.|||||:|..|:.|..|.||||||||||||||:|.:||.:|..|:::.|.|||.||||||||
  Fly     1 MGVTGLWKLIEPCGKPVPVETLEGKILAVDISIWLHQVVKGFQDNKGSALSNAHLLGLFHRLCKL 65

Human    66 LFFRIRPIFVFDGDAPLLKKQTLVKRRQRKDLASSDSRKTTEKLLKTFLKRQAIKTAFRSKRDEA 130
            |::|:||:|:|||..|.||:.|:.:|:|:::..|:::.:....||::..|.:.::.|. .|..|.
  Fly    66 LYYRVRPVFIFDGCVPQLKRDTIARRQQQRNKLSNEADRIQALLLQSLAKEKVVQQAL-GKNAEL 129

Human   131 L-------PSLTQVRRENDLYVLPPLQEEEKHSSEEEDEKEWQERMN----QKQALQEEFFHNPQ 184
            |       |...:...|:||:.||.|.......:::|.|::.....:    .:...:..:..:.|
  Fly   130 LLKSPVKRPPPAKKNDEDDLFKLPELPAASVQDNQDESEQDTSASASDSSFDESTARHSYNSSLQ 194

Human   185 AIDIESEDFSSLPPEVKHEILTDMKEFTKRRR--TLFEAMPEESDDFSQYQLKGLLKKNYLNQHI 247
            |||::|:.|.:||.:|:||||||:||..|:..  .|.| :|..||||..:|:|.|||:..:.:.:
  Fly   195 AIDVKSQHFRNLPADVRHEILTDIKETRKQSSWGRLHE-LPARSDDFCSFQMKRLLKRRAVQESL 258

Human   248 EHVQKEMNQQHSGHIRRQYE-----DEGGFLK----EVESRRVVSEDTSHYILIKGIQAKTVAEV 303
            |..::||    .||.....|     :|.|.|.    |..:|::.|::.:.::|::.::.|.:...
  Fly   259 EQAEQEM----GGHTLTYAELCDFFNEEGILTPTAIEQCTRQISSDEHTRFLLVRDLKKKAMEST 319

Human   304 DSESLPSSSKMHGMSFDVKSSPCEKLKTEKEPDATPPSPRTLLAMQAALLGSSSEEEL------- 361
            ..|              ||....|::..|:| |..|.:.....|:::..||:..:|:|       
  Fly   320 KQE--------------VKMEMIEEVPAEEE-DEKPSTSTKKEAVKSVDLGTEFDEDLAKALSMS 369

Human   362 --------------ESE-----NRRQAR----GRNAPA--------------------------- 376
                          :|:     ||.|.:    ....||                           
  Fly   370 MEETKVYDEKDYEYDSDQELRLNRAQTKQLRHAAKGPARAYMIEYGGMNDEEVGNIMEATQFNDT 434

Human   377 -----------------------------AVDEGSISPRTLSAIKRALDDDEDVKVCAGDDVQTG 412
                                         |::|.....:.:...|:.|::|: |::.   |..|.
  Fly   435 QSLEKLLEITTVPTDMADNSIEEAKLISQAIEESKQLSQAIEESKKNLNEDK-VEIV---DTDTD 495

Human   413 GPGAEEMRINSSTENSDEGLK---------------------VRDGKGIPFTATLASS------S 450
            ....|.|.:    :..|:|.|                     ..||:......|::..      .
  Fly   496 SDLEEVMEV----QELDKGKKNLEICVDITGQADSNDLFADIFEDGEANKIEKTISVEEDDDFIE 556

Human   451 VNSAEEHVASTNEGREP-TDSVPKEQMSLVHVGTEAFPISDESM-IKDRKDRLPLESAVVRHSDA 513
            |..:||....|.:..:| |:...||       ..|..|..||.: :||.::.:|.|         
  Fly   557 VKDSEELKLDTEDENKPITNKSIKE-------SNEVKPFIDEIIEVKDSQEAVPAE--------- 605

Human   514 PGLPNGRELTPASPTCTNSVSKNETHAEVLEQQNELCPYESKFDSSLLSSDDETKCKPNSASEVI 578
               ||   |.|...:..|.:.|.....:.::                |:.::|.|.||.      
  Fly   606 ---PN---LKPDLESILNDLKKQTAAVKDIQ----------------LNVNEEEKPKPK------ 642

Human   579 GPVSLQETSSIVSVPSEAVDNVENVVSFNAKEHEN--FLETIQEQQTTESA----GQDLISI--- 634
                 .|.|||:......:.:|:|:...|.|...:  .:.:..::.|.:|:    .|:||.:   
  Fly   643 -----VEISSILDELKVKMADVKNITLDNVKLSNSVPIILSSDDESTLKSSKIVPKQELIELCDS 702

Human   635 ----PKAVEPMEIDSEESESDGSFIEVQSVI--------SDEELQAEFPETSKP----------- 676
                ...:.|.:..| :::|...|.|...|:        :..|.....|:|.||           
  Fly   703 DDNKNNRLSPNKTPS-KNKSIKDFFETSYVVKRTPDKSQASNETSPGTPKTPKPFFRKRTPKSGR 766

Human   677 -----PSEQGEEELVGTREGEAPAESESLLRDNSERDDVDGEPQEAEKDAEDSLHEWQDINLEEL 736
                 .:|..:||:..|:  .:...|:||.......::...:|:|..|||.::|...:  ..|||
  Fly   767 KRASDANEDSDEEVSPTK--RSSKASKSLFEPKEPEEEKTVDPEEIIKDAAEALKSQK--TSEEL 827

Human   737 ETLESNLLAQQNSLKAQKQQQERIAATVTGQMFLESQELLRLFGIPYIQAPMEAEAQCAILDLTD 801
            :.|.:||..::..|:.::.:|:|:..:::.:|.::.||||||||||||.||||||||||.|:.||
  Fly   828 QELATNLAQERKELEIERNRQDRMGMSISQRMSIDCQELLRLFGIPYIVAPMEAEAQCAFLNATD 892

Human   802 QTSGTITDDSDIWLFGARHVYRNFFNKNKFVEYYQYVDFHNQLGLDRNKLINLAYLLGSDYTEGI 866
            .|.|||||||||||||.|.||:|||.:||.|..::..........:|.|||.||.|:|||||.||
  Fly   893 LTHGTITDDSDIWLFGGRTVYKNFFAQNKHVMEFRAEQIEQTFNCNRGKLIQLACLVGSDYTTGI 957

Human   867 PTVGCVTAMEILNEFPGHG-----------LEPLLKFSEWWHEAQKNPKIRP-NPHDTKVKKKLR 919
            ..:|.|||:|||..|.|..           |:.|:||.:|| :|.|...:.| :.....::|||:
  Fly   958 HGIGAVTALEILASFSGQDANGPGICNQSVLQTLIKFRDWW-QAHKCSNLPPGSSARLALRKKLK 1021

Human   920 TLQLTPGFPNPAVAEAYLKPVVDDSKGSFLWGKPDLDKIREFCQRYFGWNRTKTDESLFPVLKQL 984
            .::|..|||:.||.||||.|.:||::.:|.||.||::.||||.::.|||..:|||:.|.||:|::
  Fly  1022 NIELHEGFPSGAVVEAYLAPTIDDNRDAFSWGTPDVESIREFTRKSFGWTTSKTDDILMPVMKKI 1086

Human   985 DAQQTQLRIDSFF----RLAQQEKEDAKRIK--SQRLNRAVTCMLRKEKEAAASEIEAVSVAMEK 1043
            :.::.|..|.::|    .|..|:...:||::  ..:::..:.....|.|:...:.....:...:.
  Fly  1087 NEKKIQGSIRNYFTAKSALRVQQPHVSKRVQLAIDKMSGKIDETPEKPKKVTRTRRAKAAPPTDD 1151

Human  1044 EFELLDKA-KGKTQKRGITNTLEESSSLKRKRLSDSK 1079
            :..:.|.| |....|||......||..|..:..|.|:
  Fly  1152 DLAIADVATKAARPKRGKRKAAPESVVLDGELPSTSQ 1188

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ERCC5NP_000114.3 rad2 1..1029 CDD:273166 351/1219 (29%)
N-domain. /evidence=ECO:0000305|PubMed:32522879 1..78 49/76 (64%)
DNA-binding, may bind to the undamaged single-strand DNA of the DNA repair bubble. /evidence=ECO:0000269|PubMed:32821917, ECO:0000312|PDB:6TUW, ECO:0007744|PDB:6TUX 31..67 22/35 (63%)
Spacer region. /evidence=ECO:0000269|PubMed:16246722 79..785 187/879 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 306..342 8/35 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 354..385 11/116 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 404..473 16/96 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 510..533 5/22 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 667..724 16/72 (22%)
I-domain. /evidence=ECO:0000305|PubMed:32522879 786..881 57/94 (61%)
DNA-binding, may bind to the undamaged single-strand DNA of the DNA repair bubble. /evidence=ECO:0000269|PubMed:32821917, ECO:0000312|PDB:6TUW, ECO:0007744|PDB:6TUX 820..836 8/15 (53%)
DNA-binding, H2TH (helix-2turn-helix) motif which binds double-stranded DNA. /evidence=ECO:0000269|PubMed:32821917, ECO:0000312|PDB:6TUW, ECO:0007744|PDB:6TUX 848..880 21/31 (68%)
DNA-binding, may bind double-stranded DNA. /evidence=ECO:0000269|PubMed:32821917, ECO:0000312|PDB:6TUW, ECO:0007744|PDB:6TUX 912..918 1/5 (20%)
Interaction with PCNA. /evidence=ECO:0000269|PubMed:9305916 981..1009 6/31 (19%)
Interaction with ERCC6/CSB. /evidence=ECO:0000269|PubMed:16246722 1011..1186 13/72 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1056..1081 8/24 (33%)
Nuclear localization signal 1. /evidence=ECO:0000305|PubMed:26812207 1057..1074 6/16 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1095..1186
Nuclear localization signal 2. /evidence=ECO:0000305|PubMed:26812207 1169..1186
mus201NP_001027230.1 rad2 1..1122 CDD:273166 349/1204 (29%)
Blue background indicates that the domain is not in the aligned region.

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