DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Serpini1 and Spn88Eb

DIOPT Version :9

Sequence 1:	NP_033276.1	Gene:	Serpini1 / 20713	MGIID:	1194506	Length:	410	Species:	Mus musculus
Sequence 2:	NP_650427.1	Gene:	Spn88Eb / 41829	FlyBaseID:	FBgn0038299	Length:	426	Species:	Drosophila melanogaster

Alignment Length:	443	Identity:	117/443 - (26%)
Similarity:	203/443 - (45%)	Gaps:	73/443 - (16%)

- Green bases have known domain annotations that are detailed below.

Mouse     7 LALLALQSVVTGATFPDETIT-------------EWSVNMYNHLRGTGEDENILFSPLSIALAMG 58
            |.||||..|||.|......::             ::|:.:...:|......|:.|||.|...|:.
  Fly     6 LVLLALLPVVTIAALDKPELSFLNEFSQIFKGERDFSLALMKQIREIYPSGNLFFSPFSTYNALL 70

Mouse    59 MMELGAQGSTRKEIRHSM-------------GYEGLKGGEEFSFLRDFSNMASAEENQYVMKLAN 110
            :....:...|.:|:..::             .|...:..:||.:.:....::|          ||
  Fly    71 LAYFSSSEQTERELAQALNLGWALNKQQVLVSYTLAQRQDEFRWRQSPMELSS----------AN 125

Mouse   111 SLFVQNGFHVNEEFLQMLKMYFNAEVNHVDFSQNVAVA-NSINKWVENYTNSLLKDLVSPEDFDG 174
            .:||....:|:.:|..:|   :.| ...:||..:.... ..||.|:.:.|::.::|::|.|:...
  Fly   126 RIFVDRTINVSNKFNTLL---YGA-TKELDFKNDPETGLKEINDWIADKTHNQIRDMLSSEEITP 186

Mouse   175 VTNLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIY 239
            .|.|.|.||.|.||.|.|||:.|.|....|..::..:..:.||::.|.|..      :.:.|...
  Fly   187 HTMLVLANAAYMKGQWLSQFKVEETALKPFFINEREQEMVYMMHKTGAFKM------TIDEGLQS 245

Mouse   240 QVLEIPY---------------EGDEISMMLAL-SRQEVPLATLEPLLKAQLIEEWANSVKKQKV 288
            |::::||               ...:|||::.| :..::.|..:...|.|..:::|......||:
  Fly   246 QIIKLPYRTIYKSKETHISTPESKSDISMIIILPNSNKISLNRVISRLNADSVKKWFERALPQKI 310

Mouse   289 EVYLPRFTVEQEIDLKDILKALGVTEIFIKDA---NLTAMSDKKELFLSKAVHKSCIEVNEEGSE 350
            |:.||:|..||.::|..||..:||..:|.::|   :|||  |...|.:..|.|.:.|:|:|.||.
  Fly   311 ELSLPKFQFEQRLELTPILSLMGVNTMFTRNATFGDLTA--DPISLVIDDAQHLAKIKVDEVGST 373

Mouse   351 AAAASGMIAISRMAVLYP---QVIVDHPFLYLIRNRKSGIILFMGRVMNPETM 400
            ||||: ::.:||.: ..|   :...:|||::||.:.|...|||.|...:|..|
  Fly   374 AAAAT-ILLVSRSS-RQPDPTKFNCNHPFVFLIYDEKVDTILFAGVYSDPRQM 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Serpini1	NP_033276.1	neuroserpin	23..410	CDD:239003	108/427 (25%)
Spn88Eb	NP_650427.1	SERPIN	37..418	CDD:238101	106/404 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920