Protein Alignment ERCC3 and SSL2

DIOPT Version :10

• Sequence 1: XP_011509096.1
• Gene: ERCC3 / 2071
• HGNCID: 3435
• Length: 788
• Species: Homo sapiens
• Sequence 2: NP_012123.1
• Gene: SSL2 / 854663
• SGDID: S000001405
• Length: 843
• Species: Saccharomyces cerevisiae
• Alignment Length: 819
• Identity: 430/819 - (52%)
• Similarity: 561/819 - (68%)
• Gaps: 70/819 - (8%)

Human     2 GKRD--------RADRDKKKSRKRHYEDEEDDEEDAP---------GNDPQEAVPSAAGKQVDES 49
            |:||        :..|.|.||.:....|...::.||.         .:.|.:.||.:.      |
Yeast    52 GERDTGAMVTGLKKPRKKTKSSRHTAADSSMNQMDAKDKALLQDTNSDIPADFVPDSV------S 110

Human    50 GTKVDEYGAKDYRLQMPLKDDHTSRPLWVAP-DGHIFLEAFSPVYKYAQDFLVAIAEPVCRPTHV 113
            |.    :.:.|:. .:.|:.||.|||||::| ||.|.||:|||:.:.||||||.||||:.||:|:
Yeast   111 GM----FRSHDFS-YLRLRPDHASRPLWISPSDGRIILESFSPLAEQAQDFLVTIAEPISRPSHI 170

Human   114 HEYKLTAYSLYAAVSVGLQTSDITEYLRKLSKTGVPDGIMQFIKLCTVSYGKVKLVLKHNRYFVE 178
            ||||:|||||||||||||:|.||...|.:|||..|.:.|:.|||..|:||||||||:||||||||
Yeast   171 HEYKITAYSLYAAVSVGLETDDIISVLDRLSKVPVAESIINFIKGATISYGKVKLVIKHNRYFVE 235

Human   179 SCHPDVIQHLLQDPVIRECRL-RNSEGEATELITETFTSKSAHLPLSQISKTAESSGGPSTSRVT 242
            :...|::|.||.|.||...|: .:.:.:..|.:.:           .|:.:||   |.|:|:  .
Yeast   236 TTQADILQMLLNDSVIGPLRIDSDHQVQPPEDVLQ-----------QQLQQTA---GKPATN--V 284

Human   243 DPQGKSDIPMDLFDFYEQMDKDEEEEEETQTV----SFEVKQEMIEELQKRCIHLEYPLLAEYDF 303
            :|.....:      |...:..|.|.|||...:    |||:..|.:|.::|||..::||:|.||||
Yeast   285 NPNDVEAV------FSAVIGGDNEREEEDDDIDAVHSFEIANESVEVVKKRCQEIDYPVLEEYDF 343

Human   304 RNDSVNPDINIDLKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKRCL 368
            |||..|||::|||||:..:||||||||.|||||||||||:|||||||||:|||:|||||::|..:
Yeast   344 RNDHRNPDLDIDLKPSTQIRPYQEKSLSKMFGNGRARSGIIVLPCGAGKTLVGITAACTIKKSVI 408

Human   369 VLGNSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDK-PIGCSVAISTYSMLGHTTKRSWEAERV 432
            ||..|:|||.||:.||..|.|:.......||||.|:. .....:.:|||||:.:|..||.::::|
Yeast   409 VLCTSSVSVMQWRQQFLQWCTLQPENCAVFTSDNKEMFQTESGLVVSTYSMVANTRNRSHDSQKV 473

Human   433 MEWLKTQEWGLMILDEVHTIPAKMFRRVLTIVQAHCKLGLTATLVREDDKIVDLNFLIGPKLYEA 497
            |::|..:|||.:||||||.:||.|||||::.:.||.|||||||||||||||.|||||||||||||
Yeast   474 MDFLTGREWGFIILDEVHVVPAAMFRRVVSTIAAHAKLGLTATLVREDDKIGDLNFLIGPKLYEA 538

Human   498 NWMELQNNGYIAKVQCAEVWCPMSPEFYREYVAIKTKKRILLYTMNPNKFRACQFLIKFHERRND 562
            |||||...|:||.||||||||||:.|||:||:....:||:|||.|||.||:||||||::||||.|
Yeast   539 NWMELSQKGHIANVQCAEVWCPMTAEFYQEYLRETARKRMLLYIMNPTKFQACQFLIQYHERRGD 603

Human   563 KIIVFADNVFALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNPKINTIFISKVGDTSFDLPEAN 627
            |||||:|||:||:|||:::.||:|||.|.|.|||.|||||::|.:|||||:|||||||.|||||.
Yeast   604 KIIVFSDNVYALQEYALKMGKPFIYGSTPQQERMNILQNFQYNDQINTIFLSKVGDTSIDLPEAT 668

Human   628 VLIQISSHGGSRRQEAQRLGRVLRAKKGMVAEEYNAFFYSLVSQDTQEMAYSTKRQRFLVDQGYS 692
            .|||||||.||||||||||||:||||: ...|.:|||||||||:|||||.||||||.|||||||:
Yeast   669 CLIQISSHYGSRRQEAQRLGRILRAKR-RNDEGFNAFFYSLVSKDTQEMYYSTKRQAFLVDQGYA 732

Human   693 FKVITKLAGMEE-EDLAFSTKEEQQQLLQKVLAATDL--------DAEEEVVAGEFGSR--SSQA 746
            |||||.|.|||. .:||:::..|:::|||:||...:.        ||:..|..|..|.:  .|:|
Yeast   733 FKVITHLHGMENIPNLAYASPRERRELLQEVLLKNEEAAGIEVGDDADNSVGRGSNGHKRFKSKA 797

Human   747 SRRFGTMSSMSGADDTVYMEYHSSRSKAPSKHVHPLFKR 785
            .|..|::|.::|.:|..||||.::::|...:| |||.::
Yeast   798 VRGEGSLSGLAGGEDMAYMEYSTNKNKELKEH-HPLIRK 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERCC3	XP_011509096.1	rad25	60..785	CDD:273168	415/742 (56%)
SSL2	NP_012123.1	rad25	117..835	CDD:273168	415/742 (56%)