DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERCC3 and hay

DIOPT Version :9

Sequence 1:	XP_011509096.1	Gene:	ERCC3 / 2071	HGNCID:	3435	Length:	788	Species:	Homo sapiens
Sequence 2:	NP_001137931.1	Gene:	hay / 39202	FlyBaseID:	FBgn0001179	Length:	798	Species:	Drosophila melanogaster

Alignment Length:	803	Identity:	550/803 - (68%)
Similarity:	648/803 - (80%)	Gaps:	22/803 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MG--KRDRADRD--KKKSRKRHYEDEE----DDEEDAPGNDPQEAVPSAAGKQVDESGTKV--DE 55
            ||  |:.|.||.  .|..:||..|||.    .|:.|:......|.:|.||.|..:.:..::  ||
  Fly     1 MGPPKKSRKDRSGGDKFGKKRRAEDEAFTQLVDDNDSLDATESEGIPGAASKNAETNDEQINTDE 65

Human    56 YGAKDYRLQMPLKDDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLVAIAEPVCRPTHVHEYKLTA 120
            |||||||.||.|:.||.:|||||||:||:|||:||||||:|.|||:||:||||||.|:|||||||
  Fly    66 YGAKDYRSQMQLRPDHGNRPLWVAPNGHVFLESFSPVYKHAHDFLIAISEPVCRPEHIHEYKLTA 130

Human   121 YSLYAAVSVGLQTSDITEYLRKLSKTGVPDGIMQFIKLCTVSYGKVKLVLKHNRYFVESCHPDVI 185
            |||||||||||||.||.|||::||||.:|:||::||:|||:||||||||||||:||:||.||:|:
  Fly   131 YSLYAAVSVGLQTHDIVEYLKRLSKTSIPEGILEFIRLCTLSYGKVKLVLKHNKYFIESPHPEVL 195

Human   186 QHLLQDPVIRECRLRNSEGEATELITETFTSKSAHLPLSQISKTAESSGGPSTSRVTDPQGKSDI 250
            |.||:||||::|||..||||  :.|..|...|:.....:::...|.....|..:......|.:.:
  Fly   196 QKLLKDPVIQKCRLIRSEGE--DFIQGTLDGKAITQFGTKLPPGATDKPTPDPAAAAGADGTTAV 258

Human   251 PMDLFDFYEQMDKDEEEEEET--QTVSFEVKQEMIEELQKRCIHLEYPLLAEYDFRNDSVNPDIN 313
            |.|:.||||::||:||:|:|.  :||||||.||.||.:|||||.:|:|||||||||||:.|||||
  Fly   259 PEDITDFYEKIDKEEEDEDEANLKTVSFEVAQEKIEVIQKRCIEIEHPLLAEYDFRNDTNNPDIN 323

Human   314 IDLKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKRCLVLGNSAVSVE 378
            |||||.||||||||||||||||||||||||||||||||||||||||.||||||.|||.||.||||
  Fly   324 IDLKPAAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTACCTVRKRALVLCNSGVSVE 388

Human   379 QWKAQFKMWSTIDDSQICRFTSDAKDKPIGCSVAISTYSMLGHTTKRSWEAERVMEWLKTQEWGL 443
            |||.|||||||.|||.||||||:|||||:||.:.::||||:.||.|||||||:.|.||:.||||:
  Fly   389 QWKQQFKMWSTADDSMICRFTSEAKDKPMGCGILVTTYSMITHTQKRSWEAEQTMRWLQEQEWGI 453

Human   444 MILDEVHTIPAKMFRRVLTIVQAHCKLGLTATLVREDDKIVDLNFLIGPKLYEANWMELQNNGYI 508
            |:||||||||||||||||||||:||||||||||:||||||.|||||||||||||||:|||..|||
  Fly   454 MVLDEVHTIPAKMFRRVLTIVQSHCKLGLTATLLREDDKIADLNFLIGPKLYEANWLELQKKGYI 518

Human   509 AKVQCAEVWCPMSPEFYREYVAIKTKKRILLYTMNPNKFRACQFLIKFHERRNDKIIVFADNVFA 573
            |:||||||||||||||||||:..||.|::|||.|||:|||:||||||:||:|.||.|||:|||||
  Fly   519 ARVQCAEVWCPMSPEFYREYLTTKTSKKMLLYVMNPSKFRSCQFLIKYHEQRGDKTIVFSDNVFA 583

Human   574 LKEYAIRLNKPYIYGPTSQGERMQILQNFKHNPKINTIFISKVGDTSFDLPEANVLIQISSHGGS 638
            ||.|||::|||:|||||||.||:|||||||.|.|:||||:|||.|||||||||||||||||||||
  Fly   584 LKHYAIKMNKPFIYGPTSQNERIQILQNFKFNSKVNTIFVSKVADTSFDLPEANVLIQISSHGGS 648

Human   639 RRQEAQRLGRVLRAKKGMVAEEYNAFFYSLVSQDTQEMAYSTKRQRFLVDQGYSFKVITKLAGME 703
            ||||||||||:||||||.:|||||||||:||||||.||:||.|||||||:||||:||||.|.||:
  Fly   649 RRQEAQRLGRILRAKKGAIAEEYNAFFYTLVSQDTMEMSYSRKRQRFLVNQGYSYKVITHLKGMD 713

Human   704 -EEDLAFSTKEEQQQLLQKVLAATDLDAEEEVVAGEFGSR---SSQASRRFGTMSSMSGADDTVY 764
             :.||.:.|:|||.||||.||:|:|||.|:|.:.||.|.|   |..|.||.|.:|||||.||.:|
  Fly   714 TDSDLMYGTQEEQGQLLQLVLSASDLDCEDEKLPGEPGYRPSGSGGAVRRVGGLSSMSGGDDAIY 778

Human   765 MEYHSSRSKAPSKHVHPLFKRFR 787
            .|:.    |.....||||||:||
  Fly   779 YEHR----KKNIGSVHPLFKKFR 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERCC3	XP_011509096.1	rad25	60..785	CDD:273168	522/730 (72%)
		Helicase_C_3	76..198	CDD:290354	92/121 (76%)
		ResIII	321..478	CDD:282678	131/156 (84%)
		ERCC3_RAD25_C	502..745	CDD:292820	185/246 (75%)
hay	NP_001137931.1	rad25	70..795	CDD:273168	522/730 (72%)
		Helicase_C_3	86..208	CDD:290354	92/121 (76%)
		ResIII	331..488	CDD:282678	131/156 (84%)
		ERCC3_RAD25_C	512..756	CDD:292820	184/243 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141942
Domainoid	1	1.000	374	1.000	Domainoid score	I889
eggNOG	1	0.900	-	-		E1_COG1061
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H96
Inparanoid	1	1.050	1098	1.000	Inparanoid score	I236
Isobase	1	0.950	-	0	Normalized mean entropy	S335
OMA	1	1.010	-	-		QHG60829
OrthoDB	1	1.010	-	-		D100698at2759
OrthoFinder	1	1.000	-	-		FOG0003639
OrthoInspector	1	1.000	-	-		oto91318
orthoMCL	1	0.900	-	-		OOG6_100822
Panther	1	1.100	-	-	LDO	PTHR11274
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R402
SonicParanoid	1	1.000	-	-		X2506
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750