Protein Alignment ERCC3 and ptr8

DIOPT Version :10

• Sequence 1: XP_011509096.1
• Gene: ERCC3 / 2071
• HGNCID: 3435
• Length: 788
• Species: Homo sapiens
• Sequence 2: NP_593474.1
• Gene: ptr8 / 2542174
• PomBaseID: SPAC17A5.06
• Length: 804
• Species: Schizosaccharomyces pombe
• Alignment Length: 803
• Identity: 431/803 - (53%)
• Similarity: 559/803 - (69%)
• Gaps: 50/803 - (6%)

Human     5 DRADRDKKKSRKRHYEDEEDDE-EDAP----GNDPQEAVPSAAGKQVDESGTKVDEYGAKDYRLQ 64
            |.:|.|       :|.:|:||. :.||    .|:..:|..:....:..:||... .:|..|:...
pombe    23 DYSDVD-------NYGEEDDDSYKPAPRIRINNNKTKAQTTTNSNEARQSGISA-MFGQNDFSNL 79

Human    65 MPLKDDHTSRPLWVAP-DGHIFLEAFSPVYKYAQDFLVAIAEPVCRPTHVHEYKLTAYSLYAAVS 128
            :.||.|||:||||:.| ||.|.||||||:.:.|.||||.|:|||.||..:|||::||||||||||
pombe    80 LGLKLDHTARPLWINPIDGRIILEAFSPLAEQAIDFLVTISEPVSRPAFIHEYRITAYSLYAAVS 144

Human   129 VGLQTSDITEYLRKLSKTGVPDGIMQFIKLCTVSYGKVKLVLKHNRYFVESCHPDVIQHLLQDPV 193
            |||:|.||...|.:||||.:|..|:.||:.|||||||||||||.||||:||....|::.||:|||
pombe   145 VGLKTEDIIAVLDRLSKTPIPPSIVDFIRACTVSYGKVKLVLKKNRYFIESGDASVLRLLLRDPV 209

Human   194 IRECRLRNSEGEATELITETFTSKSAHLPLSQISKTAESSGGPSTSRVTDPQGKSDIPMDLFD-- 256
            |...|:..|        |::...||        ||.:..........:|:...|........|
pombe   210 IGPLRIDYS--------TQSSKQKS--------SKPSNEDNVEDKKDITNDSSKETAEKSSSDEL 258

Human   257 FYEQMDKDEEEEEETQTVSFEVKQEMIEELQKRCIHLEYPLLAEYDFRNDSVNPDINIDLKPTAV 321
            |...:...|||::|.....||:|...:|.::|||..::||||.|||||||::|||:.|||||:..
pombe   259 FSAVVGLQEEEDDEDAVHLFEIKHSSVETIKKRCAEIDYPLLEEYDFRNDNINPDLPIDLKPSTQ 323

Human   322 LRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKRCLVLGNSAVSVEQWKAQFKM 386
            :||||||||.|||||||||||:|||||||||:|||:|||||::|..:||..|:|||.||:.||..
pombe   324 IRPYQEKSLSKMFGNGRARSGIIVLPCGAGKTLVGITAACTIKKSVIVLCTSSVSVMQWRQQFLQ 388

Human   387 WSTIDDSQICRFTSDAKDK-PIGCSVAISTYSMLGHTTKRSWEAERVMEWLKTQEWGLMILDEVH 450
            ||.|....|..||:|.|:: .....|.:|||||:.:|..||::::::|::|..:|||.::|||||
pombe   389 WSNIKPDHIAVFTADHKERFHSEAGVVVSTYSMVANTRNRSYDSQKMMDFLTGREWGFILLDEVH 453

Human   451 TIPAKMFRRVLTIVQAHCKLGLTATLVREDDKIVDLNFLIGPKLYEANWMELQNNGYIAKVQCAE 515
            .:||.|||||:|.:.||.|||||||||||||||.|||||||||:||||||:|...|:||||||||
pombe   454 VVPAAMFRRVVTTIAAHTKLGLTATLVREDDKIDDLNFLIGPKMYEANWMDLAQKGHIAKVQCAE 518

Human   516 VWCPMSPEFYREYVAIKTKKRILLYTMNPNKFRACQFLIKFHERRNDKIIVFADNVFALKEYAIR 580
            |||.|:.|||.||:...::||:|||.|||.||:||||||.:||:|.||||||:|||:||:.|||:
pombe   519 VWCAMTTEFYNEYLRENSRKRMLLYIMNPKKFQACQFLIDYHEKRGDKIIVFSDNVYALRAYAIK 583

Human   581 LNKPYIYGPTSQGERMQILQNFKHNPKINTIFISKVGDTSFDLPEANVLIQISSHGGSRRQEAQR 645
            |.|.:|||.|.|.|||:||:||::|..:||||:|||||||.|||||..|||||||.|||||||||
pombe   584 LGKYFIYGGTPQQERMRILENFQYNELVNTIFLSKVGDTSIDLPEATCLIQISSHYGSRRQEAQR 648

Human   646 LGRVLRAKKGMVAEEYNAFFYSLVSQDTQEMAYSTKRQRFLVDQGYSFKVITKLAGMEE-EDLAF 709
            |||:||||: ...|.:|||||||||:|||||.||:|||.||:||||:|||||.|.|||. .:||:
pombe   649 LGRILRAKR-RNDEGFNAFFYSLVSKDTQEMYYSSKRQAFLIDQGYAFKVITNLKGMENLPNLAY 712

Human   710 STKEEQQQLLQKVL----AATDLDAEEEVVAGEFGSRS-----SQASRRFGTMSSMSGADDTVYM 765
            ::|.|:.:|||:||    .|.|||..|:.   .|||||     ::|.|..|::|:::|||:..|:
pombe   713 ASKAERLELLQEVLLQNEEAADLDDGEDT---SFGSRSLSRAPAKAKRSSGSLSTLAGADNMAYV 774

Human   766 EYHSSRS---KAPSKHVHPLFKR 785
            ||:.|.:   |..||..|.||::
pombe   775 EYNKSANKQLKKDSKEHHALFRK 797

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERCC3	XP_011509096.1	rad25	60..785	CDD:273168	417/741 (56%)
ptr8	NP_593474.1	rad25	75..797	CDD:273168	417/741 (56%)