Protein Alignment ERCC3 and xpb-1

DIOPT Version :10

• Sequence 1: XP_011509096.1
• Gene: ERCC3 / 2071
• HGNCID: 3435
• Length: 788
• Species: Homo sapiens
• Sequence 2: NP_499487.1
• Gene: xpb-1 / 176584
• WormBaseID: WBGene00013441
• Length: 789
• Species: Caenorhabditis elegans
• Alignment Length: 802
• Identity: 510/802 - (63%)
• Similarity: 618/802 - (77%)
• Gaps: 42/802 - (5%)

Human    13 KSRKRHYEDEEDDEEDAP----GNDPQE--AVPSAAGKQV---DESGTKVDEYGAKDYRLQMPLK 68
            |.|||..:.:....|:||    ||..:|  :||.||...:   :.|....||:||||||..||||
 Worm     4 KERKRRGKWDTYKAEEAPSLYSGNADKETSSVPKAASHNLNGENASSVMTDEFGAKDYRKDMPLK 68

Human    69 DDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLVAIAEPVCRPTHVHEYKLTAYSLYAAVSVGLQT 133
            .|.|:||||||||||||||:||||||:|:|||:||:||||||.|:|||:||||||||||||||||
 Worm    69 GDFTARPLWVAPDGHIFLESFSPVYKHARDFLIAISEPVCRPQHIHEYQLTAYSLYAAVSVGLQT 133

Human   134 SDITEYLRKLSKTGVPDGIMQFIKLCTVSYGKVKLVLKHNRYFVESCHPDVIQHLLQDPVIRECR 198
            .||.|||.:|||:.:|.|::.|:::|||||||||||||||||||||.|.||:|.||:|.||:.|.
 Worm   134 KDIIEYLERLSKSQLPKGVITFVQMCTVSYGKVKLVLKHNRYFVESRHSDVMQKLLKDSVIQSCI 198

Human   199 L--RNSEGEATELITETFTSKSAHLPLSQISKTAESSGGP---STSRVTDPQGKSDIPMDLFDFY 258
            |  |....:.|||..:. ..|.:|  .::..|..|..|..   :.:..||  ||  :|.|:.:||
 Worm   199 LDDRVQPAQQTELPAQE-KIKFSH--GNENEKGVEKDGAAADGTAAAATD--GK--VPADIDEFY 256

Human   259 EQMDKDEEEEEE---TQTVSFEVKQEMIEELQKRCIHLEYPLLAEYDFRNDSVNPDINIDLKPTA 320
            .::|.|:||:.|   .|.::||:|||.||.:|||||.||||||||||||||::||::.|||||:.
 Worm   257 GKIDGDDEEDAEIRNLQLLTFEIKQETIETVQKRCIELEYPLLAEYDFRNDTLNPNLGIDLKPST 321

Human   321 VLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKRCLVLGNSAVSVEQWKAQFK 385
            .|||||||||||||||.|||||||||||||||:||||||..||.||||||.||.||||||:||||
 Worm   322 TLRPYQEKSLRKMFGNSRARSGVIVLPCGAGKTLVGVTAVTTVNKRCLVLANSNVSVEQWRAQFK 386

Human   386 MWSTIDDSQICRFTSDAKD---------KPIGCSVAISTYSMLGHTTKRSWEAERVMEWLKTQEW 441
            :||||.|.|:.|||.:|||         ||:.|   ||||||:.::.:|:.:||..|::::.|||
 Worm   387 LWSTIQDKQLVRFTREAKDPAPSGADATKPVVC---ISTYSMVAYSGRRTLQAEEAMKFIEKQEW 448

Human   442 GLMILDEVHTIPAKMFRRVLTIVQAHCKLGLTATLVREDDKIVDLNFLIGPKLYEANWMELQNNG 506
            ||::||||||||||||||||||||||||||||||||||||||.|||||||||:|||||||||..|
 Worm   449 GLLLLDEVHTIPAKMFRRVLTIVQAHCKLGLTATLVREDDKITDLNFLIGPKIYEANWMELQKAG 513

Human   507 YIAKVQCAEVWCPMSPEFYREYVAIKTKKRILLYTMNPNKFRACQFLIKFHERRNDKIIVFADNV 571
            :|||||||||||||:..||..|:..:..:::||..|||||||.||||||||||||||||||:|||
 Worm   514 HIAKVQCAEVWCPMTSAFYSYYLRSQIARKLLLAVMNPNKFRICQFLIKFHERRNDKIIVFSDNV 578

Human   572 FALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNPKINTIFISKVGDTSFDLPEANVLIQISSHG 636
            ||||.|||.:.||::||.|||.|||:|||||::||::||||:|||.||||||||||||||||:||
 Worm   579 FALKRYAIEMQKPFLYGETSQNERMKILQNFQYNPRVNTIFVSKVADTSFDLPEANVLIQISAHG 643

Human   637 GSRRQEAQRLGRVLRAKKGMVAEEYNAFFYSLVSQDTQEMAYSTKRQRFLVDQGYSFKVITKLAG 701
            ||||||||||||:|||||.. .:::||||||||||||.||.||.|||||||:|||::||:..|.|
 Worm   644 GSRRQEAQRLGRILRAKKHS-TDQFNAFFYSLVSQDTVEMGYSRKRQRFLVNQGYAYKVVNNLPG 707

Human   702 MEEEDLAFSTKEEQQQLLQKVLAATDLDAEEEVVAGEFGSRSSQASRRFGTMSSMSGADDTVYME 766
            ||.|||..::||.|.||||:|||.:|.|||||.|..|....:.:.|||..||:||||....   :
 Worm   708 MELEDLKLASKESQLQLLQQVLATSDADAEEEDVKEELADGTIRISRREATMASMSGGQGA---Q 769

Human   767 YHSSRSKAPSKHVHPLFKRFRK 788
            || |::||.::. ||||||||:
 Worm   770 YH-SKAKAIAER-HPLFKRFRQ 789

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERCC3	XP_011509096.1	rad25	60..785	CDD:273168	486/741 (66%)
xpb-1	NP_499487.1	rad25	60..786	CDD:273168	486/741 (66%)