Protein Alignment AKT1 and Pka-C1

DIOPT Version :10

• Sequence 1: NP_005154.2
• Gene: AKT1 / 207
• HGNCID: 391
• Length: 480
• Species: Homo sapiens
• Sequence 2: NP_476977.1
• Gene: Pka-C1 / 34284
• FlyBaseID: FBgn0000273
• Length: 353
• Species: Drosophila melanogaster
• Alignment Length: 339
• Identity: 138/339 - (40%)
• Similarity: 204/339 - (60%)
• Gaps: 20/339 - (5%)

Human   102 AIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVIL 166
            |.:||.:.|::.:||..|....:|::.:                .:::||.:|.||.|:||:|::
  Fly    14 AAETVKEFLEQAKEEFEDKWRRNPTNTA----------------ALDDFERIKTLGTGSFGRVMI 62

Human   167 VKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYAN 231
            |:.|.|..|||||||.|:.:|...:|.|||.|.|:||..:.|||.:|:|.|:.:..|..|:||..
  Fly    63 VQHKPTKDYYAMKILDKQKVVKLKQVEHTLNEKRILQAIQFPFLVSLRYHFKDNSNLYMVLEYVP 127

Human   232 GGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLC 296
            |||:|.||.:...|||..:|||.|:||.|.:||| ..:::|||||.|||::|..|::|:||||..
  Fly   128 GGEMFSHLRKVGRFSEPHSRFYAAQIVLAFEYLH-YLDLIYRDLKPENLLIDSQGYLKVTDFGFA 191

Human   297 KEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI 361
            |. :| |.|. |.||||||||||::....|.:|||||.|||::|||..|..||:.....:::|.|
  Fly   192 KR-VK-GRTW-TLCGTPEYLAPEIILSKGYNKAVDWWALGVLVYEMAAGYPPFFADQPIQIYEKI 253

Human   362 LMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFK 426
            :..::|||...|.:.|.||..||:.|..:|.|.......:|...::||...|..:::||:..||.
  Fly   254 VSGKVRFPSHFGSDLKDLLRNLLQVDLTKRYGNLKAGVNDIKNQKWFASTDWIAIFQKKIEAPFI 318

Human   427 PQVTSETDTRYFDE 440
            |:.....||..||:
  Fly   319 PRCKGPGDTSNFDD 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AKT1	NP_005154.2	PH_PKB	4..111	CDD:269947	3/8 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..138		4/24 (17%)
		STKc_PKB_alpha	124..479	CDD:270746	131/317 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	450..480
Pka-C1	NP_476977.1	STKc_PKA	44..333	CDD:271111	130/293 (44%)