Protein Alignment AKT1 and akt-2

DIOPT Version :10

• Sequence 1: NP_005154.2
• Gene: AKT1 / 207
• HGNCID: 391
• Length: 480
• Species: Homo sapiens
• Sequence 2: NP_510357.3
• Gene: akt-2 / 181524
• WormBaseID: WBGene00000103
• Length: 528
• Species: Caenorhabditis elegans
• Alignment Length: 503
• Identity: 265/503 - (52%)
• Similarity: 352/503 - (69%)
• Gaps: 33/503 - (6%)

Human     6 IVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRP 70
            ||.|.||||:||:|:.||||||:|..|||.:|::.:|::......|||||.:.....:..::|||
 Worm    13 IVIESWLHKKGEHIRNWRPRYFILFRDGTLLGFRSKPKEDQPLPEPLNNFMIRDAATVCLDKPRP 77

Human    71 NTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVAD--------GLKKQEEEEMDFRSGSPSD 127
            |.||:|||||||||||||:.::.:.|:.|..|||.|:.        |....:||:   .:|:||.
 Worm    78 NMFIVRCLQWTTVIERTFYADSADFRQMWIEAIQAVSSHNRLKENAGNTSMQEED---TNGNPSG 139

Human   128 NSGA-------------EEMEVSLAKP-----KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGR 174
            .|..             |...:::.:|     |:.|||::|::||:||:||||||||.:||::.:
 Worm   140 ESDVNMDATSTRSDNDFESTVMNIDEPEEVPRKNTVTMDDFDFLKVLGQGTFGKVILCREKSSDK 204

Human   175 YYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHL 239
            .||:||::||::|.:.||||||||||||....|||||.||||||....:|||||:|||||||.||
 Worm   205 LYAIKIIRKEMVVDRSEVAHTLTENRVLYACVHPFLTLLKYSFQAQYHICFVMEFANGGELFTHL 269

Human   240 SRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA 304
            .|.:.|||.|.||||:||:.||.||| .:|:||||:|||||:||:||||||||||||||.||.|.
 Worm   270 QRCKTFSEARTRFYGSEIILALGYLH-HRNIVYRDMKLENLLLDRDGHIKITDFGLCKEEIKYGD 333

Human   305 TMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP 369
            ...|||||||||||||:||.||.|:|||||:||||||||||||||..:::.||||||...:::||
 Worm   334 KTSTFCGTPEYLAPEVIEDIDYDRSVDWWGVGVVMYEMMCGRLPFSAKENGKLFELITTCDLKFP 398

Human   370 RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETD 434
            ..|.|||.:||||||::.|.:|||.|.:||:|:.:..||..:.|:....|::.|||||.|.||||
 Worm   399 NRLSPEAVTLLSGLLERVPAKRLGAGPDDAREVSRAEFFKDVDWEATLRKEVEPPFKPNVMSETD 463

Human   435 TRYFDEEFTAQMITITPPDQDDSMECVDSER--RPHFPQF-SYSASGT 479
            |.:||.|||:..:.:|||.:.:.:..||.|.  :.:|.|| ||..||:
 Worm   464 TSFFDREFTSMPVQLTPPRRGEELPTVDEEEELQANFIQFASYYVSGS 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AKT1	NP_005154.2	PH_PKB	4..111	CDD:269947	53/112 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..138		7/37 (19%)
		STKc_PKB_alpha	124..479	CDD:270746	208/375 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	450..480		13/33 (39%)
akt-2	NP_510357.3	PH_PKB	11..116	CDD:269947	52/102 (51%)
		Protein Kinases, catalytic domain	184..509	CDD:473864	196/325 (60%)