DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AKT1 and akt-2

DIOPT Version :9

Sequence 1:	NP_001014431.1	Gene:	AKT1 / 207	HGNCID:	391	Length:	480	Species:	Homo sapiens
Sequence 2:	NP_510357.3	Gene:	akt-2 / 181524	WormBaseID:	WBGene00000103	Length:	528	Species:	Caenorhabditis elegans

Alignment Length:	503	Identity:	265/503 - (52%)
Similarity:	352/503 - (69%)	Gaps:	33/503 - (6%)

- Green bases have known domain annotations that are detailed below.

Human     6 IVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRP 70
            ||.|.||||:||:|:.||||||:|..|||.:|::.:|::......|||||.:.....:..::|||
Worm    13 IVIESWLHKKGEHIRNWRPRYFILFRDGTLLGFRSKPKEDQPLPEPLNNFMIRDAATVCLDKPRP 77

Human    71 NTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVAD--------GLKKQEEEEMDFRSGSPSD 127
            |.||:|||||||||||||:.::.:.|:.|..|||.|:.        |....:||:   .:|:||.
Worm    78 NMFIVRCLQWTTVIERTFYADSADFRQMWIEAIQAVSSHNRLKENAGNTSMQEED---TNGNPSG 139

Human   128 NSGA-------------EEMEVSLAKP-----KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGR 174
            .|..             |...:::.:|     |:.|||::|::||:||:||||||||.:||::.:
Worm   140 ESDVNMDATSTRSDNDFESTVMNIDEPEEVPRKNTVTMDDFDFLKVLGQGTFGKVILCREKSSDK 204

Human   175 YYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHL 239
            .||:||::||::|.:.||||||||||||....|||||.||||||....:|||||:|||||||.||
Worm   205 LYAIKIIRKEMVVDRSEVAHTLTENRVLYACVHPFLTLLKYSFQAQYHICFVMEFANGGELFTHL 269

Human   240 SRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA 304
            .|.:.|||.|.||||:||:.||.||| .:|:||||:|||||:||:||||||||||||||.||.|.
Worm   270 QRCKTFSEARTRFYGSEIILALGYLH-HRNIVYRDMKLENLLLDRDGHIKITDFGLCKEEIKYGD 333

Human   305 TMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP 369
            ...|||||||||||||:||.||.|:|||||:||||||||||||||..:::.||||||...:::||
Worm   334 KTSTFCGTPEYLAPEVIEDIDYDRSVDWWGVGVVMYEMMCGRLPFSAKENGKLFELITTCDLKFP 398

Human   370 RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETD 434
            ..|.|||.:||||||::.|.:|||.|.:||:|:.:..||..:.|:....|::.|||||.|.||||
Worm   399 NRLSPEAVTLLSGLLERVPAKRLGAGPDDAREVSRAEFFKDVDWEATLRKEVEPPFKPNVMSETD 463

Human   435 TRYFDEEFTAQMITITPPDQDDSMECVDSER--RPHFPQF-SYSASGT 479
            |.:||.|||:..:.:|||.:.:.:..||.|.  :.:|.|| ||..||:
Worm   464 TSFFDREFTSMPVQLTPPRRGEELPTVDEEEELQANFIQFASYYVSGS 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AKT1	NP_001014431.1	PH_PKB	4..111	CDD:269947	53/112 (47%)
		Inositol-(1,3,4,5)-tetrakisphosphate binding	14..19		3/4 (75%)
		Inositol-(1,3,4,5)-tetrakisphosphate binding	23..25		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..138		7/37 (19%)
		STKc_PKB_alpha	124..479	CDD:270746	208/375 (55%)
		Inhibitor binding	228..230		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	450..480		13/33 (39%)
akt-2	NP_510357.3	PH_PKB	11..116	CDD:269947	52/102 (51%)
		PH	13..115	CDD:278594	52/101 (51%)
		S_TKc	180..437	CDD:214567	167/257 (65%)
		PKc_like	184..509	CDD:304357	196/325 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	374	1.000	Domainoid score	I497
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3785
Inparanoid	1	1.050	562	1.000	Inparanoid score	I648
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D336006at33208
OrthoFinder	1	1.000	-	-		FOG0001457
OrthoInspector	1	1.000	-	-		mtm4983
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	1	1.000	-	-		X913
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.000