Protein Alignment AKT1 and akt1

DIOPT Version :10

• Sequence 1: NP_005154.2
• Gene: AKT1 / 207
• HGNCID: 391
• Length: 480
• Species: Homo sapiens
• Sequence 2: XP_004917247.1
• Gene: akt1 / 100490038
• XenbaseID: XB-GENE-484953
• Length: 493
• Species: Xenopus tropicalis
• Alignment Length: 493
• Identity: 447/493 - (90%)
• Similarity: 463/493 - (93%)
• Gaps: 13/493 - (2%)

Human     1 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKT 65
            |::|:|||||||||||||||||||||||||.||||||||||||||||.|.||||||||:||||||
 Frog     1 MNEVSIVKEGWLHKRGEYIKTWRPRYFLLKTDGTFIGYKERPQDVDQLETPLNNFSVAKCQLMKT 65

Human    66 ERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSG-SPSDNS 129
            |||:|||||||||||||||||||||::|||||||...||.|||.|||||||.|:.||| ||||||
 Frog    66 ERPKPNTFIIRCLQWTTVIERTFHVDSPEEREEWIQVIQHVADNLKKQEEEMMEVRSGDSPSDNS 130

Human   130 GAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAH 194
            ||||||||.:||||:||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   131 GAEEMEVSHSKPKHKVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAH 195

Human   195 TLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVS 259
            |||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||
 Frog   196 TLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERIFSEDRARFYGAEIVS 260

Human   260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   261 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 325

Human   325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPK 389
            ||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||
 Frog   326 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLLPEAKSLLSGLLKKDPK 390

Human   390 QRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK------------LSPPFKPQVTSETDTRYFDEEF 442
            ||||||.:||||||||:||||||||.|||||            |.||||||||||||||||||||
 Frog   391 QRLGGGPDDAKEIMQHKFFAGIVWQDVYEKKMLSVVTKQSKVELIPPFKPQVTSETDTRYFDEEF 455

Human   443 TAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA 480
            ||||||||||||||::|.||:|||||||||||||||.|
 Frog   456 TAQMITITPPDQDDNLEFVDNERRPHFPQFSYSASGNA 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AKT1	NP_005154.2	PH_PKB	4..111	CDD:269947	93/106 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..138		21/25 (84%)
		STKc_PKB_alpha	124..479	CDD:270746	340/366 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	450..480		25/29 (86%)
akt1	XP_004917247.1	PH_PKB	4..111	CDD:269947	93/106 (88%)
		Protein Kinases, catalytic domain	125..491	CDD:473864	339/365 (93%)