DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sall3 and salr

DIOPT Version :9

Sequence 1:	NP_001356062.1	Gene:	Sall3 / 20689	MGIID:	109295	Length:	1320	Species:	Mus musculus
Sequence 2:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster

Alignment Length:	1427	Identity:	405/1427 - (28%)
Similarity:	561/1427 - (39%)	Gaps:	449/1427 - (31%)

- Green bases have known domain annotations that are detailed below.

Mouse    86 EPAPPSEDFPEPSPASSPSDRTESEVAEEVAPTEGSEVKAATKEAEPMDVEVSTDKGPPGPSVPP 150
            ||...:|..||       || ||.|.|||    .|.|.:..... |.:|:.:.:..|..
  Fly    60 EPQMEAEAVPE-------SD-TERETAEE----RGEEQEPENSN-EALDLSLISSGGRE------ 105

Mouse   151 PPPALPPQPEPAAFSMP-STNVTLETLLSTKVAVAQFSQGARAGGTTGAGGSVGAVAIPMILEQL 214
                          |:| |.:|:||.|..||||||||:..|.||....|.       :.|:...:
  Fly   106 --------------SLPGSGHVSLEALQHTKVAVAQFAATAMAGNHQSAD-------LAMVQSTI 149

Mouse   215 VALQQQQIHQLQLIEQIRSQV-----ALMSR-------------QPGPPLKPSASAPGTASVQLQ 261
            ..:|:|.:.|||||:.::||:     |.:.|             :|.|..:|:           .
  Fly   150 FNVQRQHLMQLQLIQHLQSQLKRAEAAALGRHSHSDEEEEEPEPEPEPKKQPT-----------N 203

Mouse   262 GLTPHAALQLSAGPATASAGSGSTLPAAFDGPQHLSQPASGTSTPCSTSAAPPDSGAHPACSTGP 326
            ||...  |:|..||.:..           |......:.:...........|.|:......|..
  Fly   204 GLKEE--LELEQGPESEQ-----------DQESRREENSKTDKRGTEDRKAEPEGYQSMMCDI-- 253

Mouse   327 APGAVAAASSTVGNAVQPQNASTPPALGPGPLLSSASNLPNPLLPQTSSSSVIFPNPLVSI-AAT 390
               :.:.|||.:      .|...|||             ||.            ||.|..: ..|
  Fly   254 ---SSSLASSII------TNHDPPPA-------------PNE------------PNCLEMLQRRT 284

Mouse   391 ANALDPLSALMKHRKGKPPNVSVFEPK-ASAEDPFFKHKCRFCAKVFGSDSALQIHLRSHTGERP 454
            ...||..|..: |........|.:..| |.:....|||:|::|.|:|||.|||||||||||||||
  Fly   285 EEVLDSASQSL-HAAQMQEEYSEYASKEAQSRGEIFKHRCKYCGKIFGSYSALQIHLRSHTGERP 348

Mouse   455 FKCNICGNRFSTKGNLKVHFQRHKEKYPHIQMNPYPVPEYLDNVPTCSGIPYGMSLPPEKPVTTW 519
            |.||:||::|:||||||||:|||.:.:|                        .|.|||
  Fly   349 FVCNVCGSKFTTKGNLKVHYQRHTQIFP------------------------PMLLPP------- 382

Mouse   520 LDSKPVLPTVPTS-----VGLQLPPTVPGTHNYTDSPSITPVSRSPQRPSPASSECTSLSPGLNN 579
                .|.|.|..|     .|.|.|..:|      .:|.:.||.:...:               |.
  Fly   383 ----GVAPNVGHSGQGQVQGEQYPIRLP------FAPPVAPVGQEQHQ---------------NQ 422

Mouse   580 TESGITVRPESPQPL---LGGPSLTKAEPVSLPCTSTRT-----GDA--------------PVV- 621
            .|....:|.|.|.|.   |..|.:.:.|....|....:|     .||              |||
  Fly   423 VEEPEEIRQEIPVPQAEDLSKPMVKEKEKSHSPVERVKTPKEVKTDAALPSSEKPEKEISKPVVT 487

Mouse   622 ----GGQVSGLPTSA------------------ATAVTDSACTSLGSPG------LPAVSDQFKA 658
                .|.|....|||                  |..|..|:.:....|.      :..:.|:
  Fly   488 SSRRNGSVRKRQTSAVSPPQEDRERDLVEHLHIAKLVRRSSASRESQPAEYSLAQMERIIDK--- 549

Mouse   659 QFPFGGLLDSMQTSETSKLQQLVENIDKKMTDPNQCVICHRVLSCQSALKMHYRTHTGERPFKCK 723
              .:..|::..:|||||||||||:||:.|:||||||:.|.:|:||:|:|:||.|||||||||:||
  Fly   550 --SWEDLIEIDKTSETSKLQQLVDNIENKLTDPNQCIFCQKVMSCRSSLQMHIRTHTGERPFRCK 612

Mouse   724 ICGRAFTTKGNLKTHFGVHRAKPPLRVQHSCPICQKKFTNAVVLQQHIRMH-----MGGQ-IP-- 780
            ||||||.||||||.|..:|:.|||:|.|..||:|.:||:|.::||||||:|     .||| .|
  Fly   613 ICGRAFATKGNLKAHMSIHKIKPPMRSQFKCPVCHQKFSNGIILQQHIRIHTMDDGSGGQGAPAA 677

Mouse   781 -------------NTPLPEGLQEAMDADLPF-DEKNAETLSSFDDDIDE-NSMEEDSELKDTASD 830
                         |:....|..:.:|..... |.....:.||...|.|| .:|:...:.:|.:|
  Fly   678 NPGEAERLGIEDQNSNKSLGTSDTLDFSTTISDHSGQRSESSQGGDFDEFMTMDSTDDSRDNSS- 741

Mouse   831 SSKPLLSYSGSCPPSPPSVISSIAALENQMKMIDSVMNCQQLANLKSVENGSGESDRLSNDSSSA 895
                    :.:..|.|         ||.:.                  :.......|:.||.|
  Fly   742 --------AATATPHP---------LERER------------------DREKERERRIPNDCS-- 769

Mouse   896 VGDLESRSAGSPAL----SESSSSQAL---SPAHSNGESFRSKSPGLGHQEDPQEIPLKTERLDS 953
                :.||..:|.|    |||....|:   ||:.::|..|   :.||.:
  Fly   770 ----DERSHSNPDLTGGRSESGEMPAMDLSSPSSNSGRIF---ATGLAN---------------- 811

Mouse   954 PPPGPGNGGALDLTAGHPGRPLIKEEAPFSLLFLSRERGKCAS---------------------- 996
               |...||     :|:.|.|::....|.:||.::..|.:..:
  Fly   812 ---GAAGGG-----SGNGGLPMLGMPMPPNLLLMAAAREEMHALGHAHAKFPLLPFGPLGFMGLH 868

Mouse   997 ---TVCGVCGKPFACKSALEIHYRSHTKERPFVCTVCRRGCSTMGN-------LKQHLLTHK--- 1048
               .||.:|.|.....:|||.|.:|...:.|......|..||..|:       |..:|...|
  Fly   869 PPPNVCNLCFKMLPSLAALESHLQSEHAKEPATGHAQRPQCSDAGSPYGAKLTLNPNLFAKKPPS 933

Mouse  1049 ---------------------------LKELPSQ---VFDPNFTLGPSHST------PSLASSPA 1077
                                       :||.|.|   :.:...:.|....|      |..|....
  Fly   934 SSSSSSGEKLPESSNPPFPAENPPATPIKEDPDQEQLMVEEGASAGEGSGTGATSNYPQEAGDAE 998

Mouse  1078 PTMIKMEVNGHSKAIALGEGPALPAGVQVPTGPQTVMSPGLAPMLAPPPRRTPKQHNCQSCGKTF 1142
            .:::||:::.|       ..||.|...|     |.:||.|.......||  ...:|.|..|.:.|
  Fly   999 QSLMKMQLHAH-------RFPASPLDFQ-----QALMSAGPPTSSLDPP--VNNKHFCHVCRRNF 1049

Mouse  1143 SSASALQIHERTHTGEKPFGCTICGRAFTTKGNLKVHMGTHMWNNAPARRGRRLSVENPM--ALL 1205
            ||:||||||.|||||:|||.|.:|.:|||||||||||||||||.|..:|||||:|:|.||  ...
  Fly  1050 SSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNLKVHMGTHMWTNPTSRRGRRMSLELPMRPGPN 1114

Mouse  1206 GGDALKFSEMFQKDLAARAMNVDPSFWNQYAAAITNGLAMKNNEISVIQNGGIPQLPVSLGGG-A 1269
            .|.....|...|:.:..|     |..:..|.....|||..|..|:|......||..|.:.||. .
  Fly  1115 SGQGHPGSSAEQEFMQRR-----PELFFPYLPPFFNGLPPKPGELSPGAFPNIPPPPFANGGKYP 1174

Mouse  1270 IPP--LG-----AMASGVDKARTGSSPPIVSLDKASS-----ETGAS---RPFARF-IEDNK 1315
            .||  ||     |....:.:.|:.|..|  :.:.|.|     |.|:.   .|.:|. :|:|:
  Fly  1175 YPPGLLGFPGFLAQHPYILERRSSSKSP--TPEPAQSPALREEEGSGNIWHPLSRIKVENNQ 1234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sall3	NP_001356062.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..166		18/79 (23%)
		PHA03247	<242..384	CDD:223021	24/141 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	271..367		14/95 (15%)
		COG5048	419..>727	CDD:227381	125/363 (34%)
		C2H2 Zn finger	429..449	CDD:275368	14/19 (74%)
		zf-H2C2_2	441..466	CDD:338759	20/24 (83%)
		C2H2 Zn finger	457..477	CDD:275368	14/19 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	534..623		23/115 (20%)
		C2H2 Zn finger	694..714	CDD:275368	10/19 (53%)
		zf-H2C2_2	706..731	CDD:338759	20/24 (83%)
		COG5048	718..1168	CDD:227381	145/550 (26%)
		C2H2 Zn finger	722..742	CDD:275368	15/19 (79%)
		C2H2 Zn finger	754..774	CDD:275368	12/19 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..846		9/39 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	878..972		22/100 (22%)
		C2H2 Zn finger	999..1019	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1027..1047	CDD:275368	6/26 (23%)
		C2H2 Zn finger	1135..1155	CDD:275368	12/19 (63%)
		C2H2 Zn finger	1163..1183	CDD:275368	15/19 (79%)
		zf-C2H2	1163..1183	CDD:333835	15/19 (79%)
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	15/21 (71%)
		C2H2 Zn finger	323..343	CDD:275368	14/19 (74%)
		zf-H2C2_2	335..360	CDD:290200	20/24 (83%)
		C2H2 Zn finger	351..371	CDD:275368	14/19 (74%)
		C2H2 Zn finger	583..603	CDD:275368	10/19 (53%)
		zf-H2C2_2	595..620	CDD:290200	20/24 (83%)
		C2H2 Zn finger	611..631	CDD:275368	15/19 (79%)
		C2H2 Zn finger	643..663	CDD:275368	12/19 (63%)
		lambda-1	1013..>1061	CDD:212564	21/54 (39%)
		zf-C2H2	1040..1062	CDD:278523	13/21 (62%)
		C2H2 Zn finger	1042..1062	CDD:275368	12/19 (63%)
		zf-H2C2_2	1054..1079	CDD:290200	17/24 (71%)
		C2H2 Zn finger	1070..1090	CDD:275368	15/19 (79%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12058
eggNOG	1	0.900	-	-		E1_KOG1074
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47594
OrthoDB	1	1.010	-	-		D130294at33208
OrthoFinder	1	1.000	-	-		FOG0001008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23233
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X498
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.890