Protein Alignment Sp3 and Spps

DIOPT Version :9

• Sequence 1: NP_001018052.1
• Gene: Sp3 / 20687
• MGIID: 1277166
• Length: 783
• Species: Mus musculus
• Sequence 2: NP_001262902.1
• Gene: Spps / 42882
• FlyBaseID: FBgn0039169
• Length: 985
• Species: Drosophila melanogaster
• Alignment Length: 969
• Identity: 249/969 - (25%)
• Similarity: 362/969 - (37%)
• Gaps: 356/969 - (36%)

Mouse    45 AAAAAAQDTQP-SPLALLAATCSKIGPPSPGDDDEEAAVAAAAGVPAAAAGATGDLASAQLGGAP 108
            :||:||....| :|||...::.:.| ||:                     ||:...:..|:.|||
  Fly     6 SAASAATSAPPATPLAAGGSSKATI-PPN---------------------GASAAASQTQVHGAP 48

Mouse   109 NRWEVLSATPTTIKDEAGNLVQIP-----GAATSSGQYV------------LPLQ--NLQNQQIF 154
                   .|||  ..:..|:.|:|     ||...:||..            :|:|  |:..|:..
  Fly    49 -------GTPT--MQQIINIHQMPPQFAGGAVAGNGQNAGMPQNMFQIVQPMPMQTVNIDGQEAI 104

Mouse   155 SVAPGSDSSNGTVSNVQYQ-----VIPQIQSTDAQQVQIGFTGSS-----DNGGINQENSQIQII 209
            .: |..::...|...|.:.     :.|..|...|.|:......|:     ...|:.||.:|:..|
  Fly   105 FI-PNLNAQLATAQAVNFNGQQAFITPNGQILRAPQMAANPAASNCIQLQQLNGLGQEQTQLITI 168

Mouse   210 PGSNQTLLASGTPPANIQNLIPQ----------TGQVQVQGVAIGGSSFPGQTQVVANVPLGLPG 264
            ||:|..:        .:.|||.|          |.|.|.||....|::..|.|.  :.....|||
  Fly   169 PGTNIQI--------PVTNLIQQQQQAQQVHQGTVQQQAQGTNASGANGSGVTN--SGTAGQLPG 223

Mouse   265 NITFVPINSVDLDSL-----GLSGSSQTMTAGINADGHLINTGQAMDSSDNSERTGERVSPDVNE 324
            :|| :|..::.:.:.     ||.|:       |:...:|:..||:: ..:|.:.   ::.|.:.:
  Fly   224 SIT-IPGTNLQIPTSVAAANGLLGN-------ISNISNLLGGGQSI-KLENGQL---QMRPQLVQ 276

Mouse   325 TNADTDLFVPTSSSS---QLPVTIDSTGILQQNTN----SLTTTSGQVHSSDLQGNYIQSPVSEE 382
            ..|..   :|....:   |:||...:...:.|..:    :..|:||.:.:. :|...:|.|.:.:
  Fly   277 FPAPA---MPQQQQTVAVQIPVQTANGQTIYQTVHVPVQAAATSSGGLQNL-MQAQSLQMPSASQ 337

Mouse   383 TQ-----AQNIQVSTAQPVVQHLQL--------------------QDSQQPTSQAQIVQGITPQT 422
            .|     :|..|:.|....:|.:||                    |..||...|.|..|....|.
  Fly   338 MQIIPQFSQIAQIVTPNGQIQQVQLAMPYPQLPPNANIIHIQNPHQQQQQQVQQQQQQQQAQQQQ 402

Mouse   423 IHGVQASGQNISQQALQNLQLQLNPGTFLIQA-QTVTPSGQITWQTFQVQGVQNLQNLQIQNTAA 486
                ||..|...||..|.:|.|...   |:|| ...:..||:...          |.:.|.|...
  Fly   403 ----QAQQQQAQQQQQQQVQAQHQQ---LLQAISDASAGGQLPPN----------QPITITNAQG 450

Mouse   487 QQITLTPVQTLTLGQVAAGGALTSTPVSLSTG-QLPNLQTVTVNSIDSTG--------------- 535
            ||:|:.|.|.    :..|..|.|..|..:.|. |:||||.:.:.:|...|
  Fly   451 QQLTVIPAQL----RPNAPTAPTPAPAGVPTPMQMPNLQALPIQNIPGLGQVQIIHANQLPPNLP 511

Mouse   536 ----------------------IQLHPGENADSPADI--RIKEEEPD------------------ 558
                                  :|:.|.:...||..:  .||:|.||
  Fly   512 ANFQQVLTQLPMSHPQVQTQGQVQVMPKQEPQSPTQMITSIKQEPPDTFGPISATGNPPAPASTP 576

Mouse   559 ----PEEWQL------------------------------------------------------- 564
                |::.|:
  Fly   577 NTASPQQQQIKFLHTESNSLSSLSIPASIQITALPQQATNTPNTPATTQPIPVSLPARSKVNAVT 641

Mouse   565 ---------------------------------SGDSTLNTNDLTHLRVQVVDEE---------- 586
                                             :..:|:.|...:||.:.:....
  Fly   642 TSSTQITIAPTGGQVVSVTTQARGATASIRSTNTSTTTITTPSQSHLNMNISVASVGGAATGGGG 706

Mouse   587 GDQQHQEGKRLRRVACTCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGER 651
            |....:...||:|||||||||.:|   ..:..||:||||||.||.||||||||||||||||:|||
  Fly   707 GTATGEPKPRLKRVACTCPNCTDG---EKHSDKKRQHICHITGCHKVYGKTSHLRAHLRWHTGER 768

Mouse   652 PFICNWMFCGKRFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKVIHSSST 716
            ||:|:|.|||||||||||||||||||||||:|.|.||:|:|||||||:||||||...:
  Fly   769 PFVCSWAFCGKRFTRSDELQRHRRTHTGEKRFQCQECNKKFMRSDHLSKHIKTHFKSR------- 826

Mouse   717 VLASVEAGRDDALITAGGTTLILANIQQGSVSG-----IGTVNTSATSNQDILTNTEIP 770
                            .|..||..:|:|.:..|     |.|||...|        .|||
  Fly   827 ----------------SGVELIELSIKQETKGGNAPKSISTVNGIVT--------IEIP 861

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sp3	NP_001018052.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..55		4/9 (44%)
		Transactivation domain (Gln-rich). /evidence=ECO:0000250	140..239		28/132 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	302..340		6/40 (15%)
		Transactivation domain (Gln-rich). /evidence=ECO:0000250	352..501		42/178 (24%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:Q02447	463..471		0/7 (0%)
		Repressor domain. /evidence=ECO:0000250	536..622		30/207 (14%)
		C2H2 Zn finger	625..647	CDD:275368	19/21 (90%)
		COG5048	<638..720	CDD:227381	58/81 (72%)
		zf-H2C2_2	639..666	CDD:290200	22/26 (85%)
		C2H2 Zn finger	655..677	CDD:275368	19/21 (90%)
		zf-H2C2_2	669..692	CDD:290200	18/22 (82%)
		zf-C2H2	683..705	CDD:278523	16/21 (76%)
		C2H2 Zn finger	685..705	CDD:275368	15/19 (79%)
Spps	NP_001262902.1	COG5048	<725..827	CDD:227381	78/127 (61%)
		C2H2 Zn finger	742..764	CDD:275368	19/21 (90%)
		zf-H2C2_2	756..783	CDD:290200	22/26 (85%)
		C2H2 Zn finger	772..794	CDD:275368	19/21 (90%)
		zf-H2C2_2	786..809	CDD:290200	18/22 (82%)
		zf-C2H2	800..822	CDD:278523	16/21 (76%)
		C2H2 Zn finger	802..822	CDD:275368	15/19 (79%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10864
eggNOG	1	0.900	-	-		E33208_3BGI1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3300
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44039
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6780
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.990