DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sp1 and Spps

DIOPT Version :9

Sequence 1:	NP_038700.2	Gene:	Sp1 / 20683	MGIID:	98372	Length:	781	Species:	Mus musculus
Sequence 2:	NP_001262902.1	Gene:	Spps / 42882	FlyBaseID:	FBgn0039169	Length:	985	Species:	Drosophila melanogaster

Alignment Length:	994	Identity:	279/994 - (28%)
Similarity:	367/994 - (36%)	Gaps:	352/994 - (35%)

- Green bases have known domain annotations that are detailed below.

Mouse    26 GGSG------NGGGAAFSQTRSSSTGSSSS--------------SGG---GGGQES--------- 58
            |||.      ||..||.|||:......:.:              :||   |.||.:
  Fly    23 GGSSKATIPPNGASAAASQTQVHGAPGTPTMQQIINIHQMPPQFAGGAVAGNGQNAGMPQNMFQI 87

Mouse    59 -QPSPLALLAATCSR-IESPNENSNNSQGPSQSGGTGELDLTAAQLSQGANGWQIISSSSGATPT 121
             ||.|:..:...... |..||.|:               .|..|| :...||.|...:.:|....
  Fly    88 VQPMPMQTVNIDGQEAIFIPNLNA---------------QLATAQ-AVNFNGQQAFITPNGQILR 136

Mouse   122 SKEQSGN--STN----------GSESSKNRTVSGGQYVVAATPNLQNQQVLTGLPGVMPNIQYQV 174
            :.:.:.|  ::|          |.|.::..|:.|....:..|..:|.||            |.|.
  Fly   137 APQMAANPAASNCIQLQQLNGLGQEQTQLITIPGTNIQIPVTNLIQQQQ------------QAQQ 189

Mouse   175 IPQFQTVDGQQLQ----FAATGAQVQQDG-SGQIQ---IIPGANQQI----------------IP 215
            :.| .||. ||.|    ..|.|:.|...| :||:.   .|||.|.||                |.
  Fly   190 VHQ-GTVQ-QQAQGTNASGANGSGVTNSGTAGQLPGSITIPGTNLQIPTSVAAANGLLGNISNIS 252

Mouse   216 NRGSGGNII------------------AAMPNLLQQAVPLQGLANNVLSGQTQYVT-NVPVALNG 261
            |...||..|                  .|||. .||.|.:| :.....:|||.|.| :|||
  Fly   253 NLLGGGQSIKLENGQLQMRPQLVQFPAPAMPQ-QQQTVAVQ-IPVQTANGQTIYQTVHVPV---- 311

Mouse   262 NITLLPVNSVSAATLTPSSQAGTISSSGSQESSSQPVTSGTAISSASLVSSQASSSSFFTNANSY 326
                               ||...||.|.|          ..:.:.||....||........:..
  Fly   312 -------------------QAAATSSGGLQ----------NLMQAQSLQMPSASQMQIIPQFSQI 347

Mouse   327 STTTTTS-----------------NMGIMNFTSSGSSGTSSQGQTPQRVGGLQGSDSLNIQQNQT 374
            :...|.:                 |..|::.            |.|.:    |....:..||.|.
  Fly   348 AQIVTPNGQIQQVQLAMPYPQLPPNANIIHI------------QNPHQ----QQQQQVQQQQQQQ 396

Mouse   375 SGGSLQGSQQKEGEQSQQTQQQQILIQPQLVQGGQALQALQAAPLSGQTFTTQAISQETLQNLQL 439
            ..   |..||.:.:|:||.||||:..|.|     |.|||:..|...||....|.|:....|..||
  Fly   397 QA---QQQQQAQQQQAQQQQQQQVQAQHQ-----QLLQAISDASAGGQLPPNQPITITNAQGQQL 453

Mouse   440 QAVQNSGPIIIR-----TPTVGPNG------QVSWQTLQLQNL----QVQNPQA----------- 478
            ..:    |..:|     .||..|.|      ..:.|.|.:||:    |||...|
  Fly   454 TVI----PAQLRPNAPTAPTPAPAGVPTPMQMPNLQALPIQNIPGLGQVQIIHANQLPPNLPANF 514

Mouse   479 -QTITLAPM-------QG---VSLGQTSSSNT------------TLTPIASAASIPAGTVTVNAA 520
             |.:|..||       ||   |...|...|.|            |..||::..:.||...|.|.|
  Fly   515 QQVLTQLPMSHPQVQTQGQVQVMPKQEPQSPTQMITSIKQEPPDTFGPISATGNPPAPASTPNTA 579

Mouse   521 QLSSMPGLQTI--------NLSALG-TSGIQVHQLPGLPLAIANTPG------------------ 558
            .    |..|.|        :||:|. .:.||:..||.......|||.
  Fly   580 S----PQQQQIKFLHTESNSLSSLSIPASIQITALPQQATNTPNTPATTQPIPVSLPARSKVNAV 640

Mouse   559 -DHGTQLGLHGSGGDGIH-----------------------------------------DETAGG 581
             ...||:.:..:||..:.                                         ..|.||
  Fly   641 TTSSTQITIAPTGGQVVSVTTQARGATASIRSTNTSTTTITTPSQSHLNMNISVASVGGAATGGG 705

Mouse   582 EGENSSDLQPQAGRRTRREACTCPYCKDSEGRASGDPGKKKQHICHIQGCGKVYGKTSHLRAHLR 646
            .|..:.:.:|    |.:|.|||||.|.|.|..:.    ||:||||||.||.||||||||||||||
  Fly   706 GGTATGEPKP----RLKRVACTCPNCTDGEKHSD----KKRQHICHITGCHKVYGKTSHLRAHLR 762

Mouse   647 WHTGERPFMCNWSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTHQNKKG 711
            ||||||||:|:|::||||||||||||||:|||||||:|.|.||.|:||||||||||||||...:.
  Fly   763 WHTGERPFVCSWAFCGKRFTRSDELQRHRRTHTGEKRFQCQECNKKFMRSDHLSKHIKTHFKSRS 827

Mouse   712 GPGVALSVGTLPLDSGAGSEGTATPSALITTN-MVAMEAICPEGIARLANSGINVMQVT------ 769
            |      |..:.|.....::|...|.::.|.| :|.:|  .|.|.:..|.||.:.:..|
  Fly   828 G------VELIELSIKQETKGGNAPKSISTVNGIVTIE--IPGGGSAAAGSGASSVAATVAGSTV 884

Mouse   770 --------ELQSINISGNG 780
                    :|.::..||.|
  Fly   885 TPGGATIVQLPTVEASGGG 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sp1	NP_038700.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..95		22/102 (22%)
		Repressor domain. /evidence=ECO:0000250	2..84		22/91 (24%)
		Transactivation domain A (Gln-rich). /evidence=ECO:0000250	145..250		38/146 (26%)
		Transactivation domain B (Gln-rich). /evidence=ECO:0000250	260..494		64/287 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..300		6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..395		15/81 (19%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:P08047	461..469		2/7 (29%)
		Transactivation domain C (highly charged). /evidence=ECO:0000250	495..608		39/193 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..595		8/72 (11%)
		VZV IE62-binding. /evidence=ECO:0000250	617..781		93/179 (52%)
		C2H2 Zn finger	626..648	CDD:275368	19/21 (90%)
		COG5048	<639..710	CDD:227381	58/70 (83%)
		zf-H2C2_2	640..667	CDD:290200	22/26 (85%)
		C2H2 Zn finger	656..678	CDD:275368	17/21 (81%)
		zf-H2C2_2	670..693	CDD:290200	17/22 (77%)
		zf-C2H2	684..706	CDD:278523	17/21 (81%)
		C2H2 Zn finger	686..706	CDD:275368	16/19 (84%)
		Domain D. /evidence=ECO:0000250	706..781		20/90 (22%)
Spps	NP_001262902.1	COG5048	<725..827	CDD:227381	78/105 (74%)
		C2H2 Zn finger	742..764	CDD:275368	19/21 (90%)
		zf-H2C2_2	756..783	CDD:290200	22/26 (85%)
		C2H2 Zn finger	772..794	CDD:275368	17/21 (81%)
		zf-H2C2_2	786..809	CDD:290200	17/22 (77%)
		zf-C2H2	800..822	CDD:278523	17/21 (81%)
		C2H2 Zn finger	802..822	CDD:275368	16/19 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841785
Domainoid	1	1.000	49	1.000	Domainoid score	I11726
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3300
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1085860at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44039
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6780
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.030