DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox9 and Sox100B

DIOPT Version :9

Sequence 1:	NP_035578.3	Gene:	Sox9 / 20682	MGIID:	98371	Length:	507	Species:	Mus musculus
Sequence 2:	NP_651839.1	Gene:	Sox100B / 45039	FlyBaseID:	FBgn0024288	Length:	529	Species:	Drosophila melanogaster

Alignment Length:	580	Identity:	166/580 - (28%)
Similarity:	222/580 - (38%)	Gaps:	192/580 - (33%)

- Green bases have known domain annotations that are detailed below.

Mouse    29 DSAGSPCPSGSGSDTENTRPQENTFPKGEPDL------KKESEEDKFPVCIREAVSQVLKGYDWT 87
            ||:.|.|........| |....|...|.|...      :||.|.      |..||.:||:||||.
  Fly     3 DSSSSNCSKDRAKPVE-TLVLANYALKAEQKKAQGQGGRKEDER------ITTAVMKVLEGYDWN 60

Mouse    88 LVPMPVRVNGSSKNKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESEKR 152
            ||....:. .:.:.|.|:||||||||||||||||.::.|||||.|:||||:|||||:.|.:|:|:
  Fly    61 LVQASAKA-PTDRKKEHIKRPMNAFMVWAQAARRVMSKQYPHLQNSELSKSLGKLWKNLKDSDKK 124

Mouse   153 PFVEEAERLRVQHKKDHPDYKYQPRRRK---------------------------------SVKN 184
            ||:|.||:||:.||::||||||||||:|                                 |..|
  Fly   125 PFMEFAEKLRMTHKQEHPDYKYQPRRKKARVLPSQQSGEGGSPGPEMTLSATMGSSGKPRSSNSN 189

Mouse   185 GQAEAEE----------ATEQTH----------ISPNAIFKALQA----------------DSPH 213
            ||..|.:          |:..:|          .|..|..|:|.:                |||.
  Fly   190 GQRRAGKGNAAADLGSCASTISHANVGSNSSDVFSNEAFMKSLNSACAASLMEQSLIETGLDSPC 254

Mouse   214 S-SSGMSEVHSPGEHSGQSQGPPTPPTTP----KTDVQAGKVD-----LKREGRPLA-------- 260
            | :|.||.:              |||.||    .::.:|...:     |::...|:|
  Fly   255 STASSMSSL--------------TPPATPYNVAPSNAKASAANNPSLLLRQLSEPVANAGDGYGV 305

Mouse   261 --EGGRQPPIDFRDVDIGEL-----SSDVISNIETFDVNEFDQYLPP-NGHPGVPATHGQVTYTG 317
              |.||:      .|.|||:     |:.|.|..|.....:...:|.. ||:.|         |||
  Fly   306 LLEAGRE------YVAIGEVNYQGQSAGVQSGAEGGGAGQEMDFLENINGYGG---------YTG 355

Mouse   318 SYGISSTAPTPATAGHVWMSKQQAPPPPPQQPPQAPQAPQAPP---------------QQQAPPQ 367
            |.........||..||....:||     .||..||.:|....|               .|..|..
  Fly   356 SRVSYPAYSYPANGGHFATEEQQ-----QQQALQASEALNYKPAAADIDPKEIDQYFMDQMLPMT 415

Mouse   368 QPQAPQ-----QQQAHTLTTLSSEPGQSQRTHIKTEQLSPSHYSEQQQHSPQQISYSPFNLPHYS 427
            |...|.     ....|....|:|....|......:.|...:.|.|...:||...|.|  ..|::.
  Fly   416 QHHHPHHTHPLHHPLHHSPPLNSSASLSSACSSASSQQPVAEYYEHLGYSPAASSAS--QNPNFG 478

Mouse   428 PSYPPIT------------------RSQYDYADHQNSGSYYSHAAGQGSGLYSTFTYMNP 469
            |..|...                  :||.....|||...::         |:.|:||:||
  Fly   479 PQQPYANGAASMTPTLGDPAPQQELQSQQQEQQHQNPSQHH---------LWGTYTYVNP 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox9	NP_035578.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67		12/43 (28%)
		Sox_N	22..94	CDD:315171	23/70 (33%)
		Dimerization (DIM). /evidence=ECO:0000250\|UniProtKB:P48436	63..103		13/39 (33%)
		PQA. /evidence=ECO:0000250\|UniProtKB:P48436	63..103		13/39 (33%)
		SOX-TCF_HMG-box	104..174	CDD:238684	48/69 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..271		45/199 (23%)
		Transactivation domain (TAM). /evidence=ECO:0000250\|UniProtKB:P48436	224..307		24/107 (22%)
		9aaTAD 1. /evidence=ECO:0000250\|UniProtKB:P48436	275..284		5/13 (38%)
		9aaTAD 2. /evidence=ECO:0000250\|UniProtKB:P48436	290..298		0/7 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..429		24/113 (21%)
		Transactivation domain (TAC). /evidence=ECO:0000250\|UniProtKB:P48436	392..507		21/96 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..507
Sox100B	NP_651839.1	SOX-TCF_HMG-box	76..146	CDD:238684	48/69 (70%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	115	1.000	Domainoid score	I5999
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	150	1.000	Inparanoid score	I4360
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	1	1.000	-	-		otm42976
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45803
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1210
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.960